Results 191 to 200 of about 990,872 (342)

Supplementary Figures 1 - 8 from The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology

, 2023
Ogan D. Abaan, Eric C. Polley, Sean Davis, Yuelin J. Zhu, Sven Bilke, Robert L. Walker, Marbin Pineda, Yevgeniy Gindin, Yuan Jiang, William C. Reinhold, Susan L. Holbeck, Richard Simon, James H. Doroshow, Yves Pommier, Paul S. Meltzer   +14 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Identification of Prognostic Biomarker Signatures and Candidate Drugs in Colorectal Cancer: Insights from Systems Biology Analysis

, 2018
Rezanur Rahman, Tania Islam, Esra Göv, Beste Turanlı, Gizem Gülfidan, Md. Shahjaman, Nilufa Akhter Banu, Nurul Haque Mollah, Kazım Yalçın Arğa, Mohammad Ali Moni   +9 more
openalex   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Integrative systems biology reveals NKG2A-biased immune responses correlate with protection in infectious disease, autoimmune disease, and cancer [PDF]

Daniel Chen, Jingyi Xie, Jongchan Choi, Raymond T. Ng, Rongyu Zhang, Sarah Li, Rick Edmark, Hong Zheng, Benjamin D. Solomon, Katie M. Campbell, Egmidio Medina, Antoni Ribas, Purvesh Khatri, Lewis L. Lanier, Philip J. Mease, Jason D. Goldman, Yapeng Su, James R. Heath   +17 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Supplementary Figure S5 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer

Annabelle Nwaokorie, Walter Kölch, Dirk Fey   +2 more
openalex   +1 more source

Identifying Molecular Determinants and Therapeutic Targets in Luminal B Breast Cancer: A Systems Biology Approach [PDF]

Yousef Saeidi, Masoud Ghorbani, Ali Najafi, Mehrdad Moosazadeh Moghaddam   +3 more
openalex   +1 more source

Data from The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology

, 2023
Ogan D. Abaan, Eric C. Polley, Sean Davis, Yuelin J. Zhu, Sven Bilke, Robert L. Walker, Marbin Pineda, Yevgeniy Gindin, Yuan Jiang, William C. Reinhold, Susan L. Holbeck, Richard Simon, James H. Doroshow, Yves Pommier, Paul S. Meltzer   +14 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source