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Disease Models & Mechanisms: a short history of supporting early-career researchers.
Dis Model MechHackett R.
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2010
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
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Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
+5 more sources
Current Opinion in Oncology, 2005
Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
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Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
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Cancer: A Systems Biology disease
Biosystems, 2006Cancer research has focused on the identification of molecular differences between cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules out of many parallel signal transduction pathways are involved. Their activities appear to be controlled by multiple factors.
Hornberg, J.J. +3 more
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2011
Cancer is a complex disease, resulting from system-wide interactions of biological processes rather than from any single underlying cause. The processes that drive all cancer development and progression have been termed the ‘hallmarks of cancer’. With the growth of large-scale measurements of numerous molecular and cellular properties, a new approach ...
Elana J. Fertig +2 more
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Cancer is a complex disease, resulting from system-wide interactions of biological processes rather than from any single underlying cause. The processes that drive all cancer development and progression have been termed the ‘hallmarks of cancer’. With the growth of large-scale measurements of numerous molecular and cellular properties, a new approach ...
Elana J. Fertig +2 more
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2015
With over 200 types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies.
Paola Allavena +2 more
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With over 200 types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies.
Paola Allavena +2 more
openaire +3 more sources
Introduction: Cancer Systems and Integrative Biology
2023The insights provided by the holistic approaches of systems and integrative biology offer a means to address the multiple levels of complexity evident in cancer biology. Often focused on the use of large-scale, high-dimensional omics data for discovery in silico, integration with lower-dimensional data and lower-throughput wet laboratory studies allows
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Systems biology of cancer biomarker detection
Cancer Biomarkers, 2013Cancer systems-biology is an ever-growing area of research due to explosion of data; how to mine these data and extract useful information is the problem. To have an insight on carcinogenesis one need to systematically mine several resources, such as databases, microarray and next-generation sequences. This review encompasses management and analysis of
Sanga, Mitra +2 more
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Systems Biology Approaches in Cancer Pathology
2018The complex network of the tissue system, in both pre-neoplastic tissues and tumors, demonstrates the need for a systems biology approach to cancer pathology, in which quantification of key tissue system processes is combined with informatics tools to produce actionable scores to aid clinical decision-making.
Aaron, DeWard +1 more
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