Results 291 to 300 of about 1,632,468 (362)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Editorial for Special Issue "New Insight: Enzymes as Targets for Drug Development in Current Issues in Molecular Biology". [PDF]

Curr Issues Mol Biol
Kim SK.
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach. [PDF]

Biochem Biophys Rep
Heydari A, Yaghmoorian Khojini J, Hayati MJ, Khara F, Abootorabi SMS, Manoochehri H, Mousavi MJ.   +6 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Integrating allostasis and emerging technologies to study complex diseases. [PDF]

Commun Biol
Park I, Gwon H, Jung Y, Kim B, Ju G, Sin E, An HI, Bang HJ, Yun T, Lee SH, Lee W, Jang CG, Lee HJ, Kim CS, Lee J, Lee S.   +15 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Editorial: Epigenetic and metabolic regulators of breast carcinogenesis, volume II. [PDF]

Front Oncol
Saber-Ayad M, Elemam NM, Talaat IM, Busch H.   +3 more
europepmc   +1 more source

Tracking CTC Dynamics: Trop2 and EpCAM in Metastatic Breast Cancer Progression. [PDF]

Cancers (Basel)
González Á, Alegre E.
europepmc   +1 more source

RNA-Targeting Techniques: A Comparative Analysis of Modern Approaches for RNA Manipulation in Cancer Research and Therapeutics. [PDF]

Genes (Basel)
Boti MA, Diamantopoulos MA, Scorilas A.
europepmc   +1 more source