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Abstract In contrast to prevailing wisdom that cancer is a genetic disease that evolves via Darwinian selection, it is increasingly recognized that in addition to genetic mutations, intratumoral heterogeneity also results through non-genetic mechanisms.
Ravi Salgia +3 more
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Ravi Salgia +3 more
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Systems Biology Applied to Cancer Research
2009Complex diseases such as cancer have multiple origins and are therefore difficult to understand and cure. Highly parallel technologies such as DNA microarrays are now available. These provide a data deluge which needs to be mined for relevant information and integrated to existing knowledge at different scales.
Seigneuric, Renaud +6 more
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Medecine sciences : M/S, 2010
Cancer Systems Biology is now accepted and recognized as a promising field both in biological and clinical research. It relies on a rigorous formalization of regulation networks into precise and unambiguous languages. It provides both detailed and modular views of the complex biological system of interest (which in cancer research is typically an ...
Emmanuel, Barillot +2 more
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Cancer Systems Biology is now accepted and recognized as a promising field both in biological and clinical research. It relies on a rigorous formalization of regulation networks into precise and unambiguous languages. It provides both detailed and modular views of the complex biological system of interest (which in cancer research is typically an ...
Emmanuel, Barillot +2 more
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Bioinformatics and Systems Biology of Cancers
2010Molecular databases and bioinformatics methods and tools are essential for modern cancer research. Multilevel analyses of all the protein-coding genes, thousands of proteins, and hundreds of metabolites require integration in terms of signaling and metabolic pathways and networks.
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Navigating Cancer Systems Biology
Cancer systems biology integrates experimental models, data analysis, and dynamic network modeling to elucidate the complex mechanisms underlying cancer progression. This chapter outlines the essential requirements for experimental models, emphasizing the need for well-characterized cancer subtypes and high-quality mouse models that mimic clinical ...openaire +1 more source