Results 311 to 320 of about 1,632,468 (362)
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Current Opinion in Oncology, 2005
Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
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Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
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Cancer: A Systems Biology disease
Biosystems, 2006Cancer research has focused on the identification of molecular differences between cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules out of many parallel signal transduction pathways are involved. Their activities appear to be controlled by multiple factors.
Hornberg, J.J. +3 more
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Systems Biology Approaches in Cancer Pathology.
Methods in molecular biology, 2018The complex network of the tissue system, in both pre-neoplastic tissues and tumors, demonstrates the need for a systems biology approach to cancer pathology, in which quantification of key tissue system processes is combined with informatics tools to produce actionable scores to aid clinical decision-making.
Aaron D. Deward, R. Critchley-Thorne
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, 2015
With over 200 types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies.
S. Thiagalingam
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With over 200 types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies.
S. Thiagalingam
semanticscholar +4 more sources
Realizing Cancer Precision Medicine by Integrating Systems Biology and Nanomaterial Engineering
Advances in Materials, 2020Many clinical trials for cancer precision medicine have yielded unsatisfactory results due to challenges such as drug resistance and low efficacy. Drug resistance is often caused by the complex compensatory regulation within the biomolecular network in a
J. Joo +6 more
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Omics/systems biology and cancer cachexia.
Seminars in Cell & Developmental Biology, 2016 Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology.
I. Gallagher +4 more
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Systems Biology and the Molecular Circuits of Cancer
ChemBioChem, 2004AbstractProliferative disorders are a major challenge for human health. The understanding of the organization of cell‐cycle events is of the utmost importance to devise effective therapeutic strategies for cancer. The awareness that cells and organisms are complex, modular, hierarchical systems and the availability of genome‐wide gene expression and ...
ALBERGHINA, LILIA +2 more
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2011
Cancer is a complex disease, resulting from system-wide interactions of biological processes rather than from any single underlying cause. The processes that drive all cancer development and progression have been termed the ‘hallmarks of cancer’. With the growth of large-scale measurements of numerous molecular and cellular properties, a new approach ...
Elana J. Fertig +2 more
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Cancer is a complex disease, resulting from system-wide interactions of biological processes rather than from any single underlying cause. The processes that drive all cancer development and progression have been termed the ‘hallmarks of cancer’. With the growth of large-scale measurements of numerous molecular and cellular properties, a new approach ...
Elana J. Fertig +2 more
openaire +1 more source