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Systems Biology and the Molecular Circuits of Cancer
ChemBioChem, 2004AbstractProliferative disorders are a major challenge for human health. The understanding of the organization of cell‐cycle events is of the utmost importance to devise effective therapeutic strategies for cancer. The awareness that cells and organisms are complex, modular, hierarchical systems and the availability of genome‐wide gene expression and ...
ALBERGHINA, LILIA +2 more
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The chemokine system in cancer biology and therapy
Cytokine & Growth Factor Reviews, 2010Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose to cancer. Components of the chemokine system affect in a cell autonomous or non-autonomous way multiple pathways ...
A. Mantovani +5 more
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Systems biology of breast cancer
Current Breast Cancer Reports, 2009Recent technological advances are permitting a comprehensive cataloging of the molecular aberrations that underlie breast cancer. Systems biology uses the large amount of information generated by efforts to characterize tumors at the DNA, RNA, and protein levels to build the networks of components and pathways that recapitulate the development of ...
Gabriel N. Hortobagyi +3 more
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The role of kisspeptin system in cancer biology
Critical Reviews in Oncology/Hematology, 2019Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their antimetastatic activities in several malignancies. Herein we report recent evidence of the role of kisspeptins in cancer biology and we examine the prospective of ...
Martha Stathaki +7 more
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Systems biology of cancer biomarker detection
Cancer Biomarkers, 2013Cancer systems-biology is an ever-growing area of research due to explosion of data; how to mine these data and extract useful information is the problem. To have an insight on carcinogenesis one need to systematically mine several resources, such as databases, microarray and next-generation sequences. This review encompasses management and analysis of
Jayprokas Chakrabarti +2 more
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Bioinformatics and Systems Biology of Cancers
2010Molecular databases and bioinformatics methods and tools are essential for modern cancer research. Multilevel analyses of all the protein-coding genes, thousands of proteins, and hundreds of metabolites require integration in terms of signaling and metabolic pathways and networks.
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2010
Foreword Hiroaki Kitano, President, The Systems Biology Institute, Tokyo, Japan CANCER SYSTEMS BIOLOGY: CONCEPTS AND APPLICATIONS A Roadmap of Cancer Systems Biology Edwin Wang Network Biology, the Framework of Systems Biology Jing-Dong Han Reconstructing Gene Networks Using Gene Expression Profiles Mario Lauria and Diego di Bernardo Understanding ...
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Foreword Hiroaki Kitano, President, The Systems Biology Institute, Tokyo, Japan CANCER SYSTEMS BIOLOGY: CONCEPTS AND APPLICATIONS A Roadmap of Cancer Systems Biology Edwin Wang Network Biology, the Framework of Systems Biology Jing-Dong Han Reconstructing Gene Networks Using Gene Expression Profiles Mario Lauria and Diego di Bernardo Understanding ...
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Introduction: Cancer Systems and Integrative Biology
2023The insights provided by the holistic approaches of systems and integrative biology offer a means to address the multiple levels of complexity evident in cancer biology. Often focused on the use of large-scale, high-dimensional omics data for discovery in silico, integration with lower-dimensional data and lower-throughput wet laboratory studies allows
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Cancer Systems Biology: Concepts and Applications
, 2010Foreword Hiroaki Kitano, President, The Systems Biology Institute, Tokyo, Japan CANCER SYSTEMS BIOLOGY: CONCEPTS AND APPLICATIONS A Roadmap of Cancer Systems Biology Edwin Wang Network Biology, the Framework of Systems Biology Jing-Dong Han ...
E. Wang
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