Results 71 to 80 of about 1,632,468 (362)

Utilizing RNA-Seq Data for Cancer Network Inference

, 2012
An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S., Cai, Ying, Fendler, Bernard   +2 more
core   +1 more source

Rac1 drives intestinal stem cell proliferation and regeneration [PDF]

, 2013
Adult stem cells are responsible for maintaining the balance between cell proliferation and differentiation within self-renewing tissues. The molecular and cellular mechanisms mediating such balance are poorly understood.
Alessandro Scopelliti, Amcheslavsky, Ashton, Biteau, Brand, Buchon, Buchon, Choi, Cordero, el Marjou, Ellenbroek, Hochmuth, Ito, Jiang, Julia Cordero, Kevin Myant, Kitagishi, Marcos Vidal, Micchelli, Miyamoto, Myant, Ohlstein, Owen Sansom, Owusu-Ansah, Radtke, Sara Haque, Tothova, Tsatmali, Walmsley   +28 more
core   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Metabolic network reconstruction of Chlamydomonas offers insight into light‐driven algal metabolism

Molecular Systems Biology, 2011
Metabolic network reconstruction encompasses existing knowledge about an organism's metabolism and genome annotation, providing a platform for omics data analysis and phenotype prediction.
Roger L Chang, Lila Ghamsari, Ani Manichaikul, Erik F Y Hom, Santhanam Balaji, Weiqi Fu, Yun Shen, Tong Hao, Bernhard Ø Palsson, Kourosh Salehi‐Ashtiani, Jason A Papin   +10 more
doaj   +1 more source

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. [PDF]

, 2018
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female.
Abe, Akalin, Alison E. Casey, Ankit Sinha, Asselin-Labat, Buenrostro, Cardiff, Cerami, Cheryl Arrowsmith, Chlebowski, Cox, Cox, Dalia Barsyte-Lovejoy, Daniel De Carvalho, Deugnier, Dos Santos, Edgar, Eirew, Eirew, Eisen, Erik Drysdale, Gary Bader, Gascard, Genevieve Deblois, Gu, Hal Berman, Heinz, Hennighausen, Herschkowitz, Hu, Hui Fang, Huston, Hyeyeon Kim, Ignatchenko, Jackson, Jennifer Cruickshank, Joshi, Joshi, Joshi, Julie Livingstone, Kaltenborn, Kauff, Kelsey, Kendrick, Kiechl, Kislinger, Koboldt, Kotsopoulos, Krueger, Kucera, Labarge, Li, Lim, Lim, Lin, Loenen, Lucas, Lydon, Marotti, Maruyama, Mathieu Lupien, McLean, Meissner, Merico, Michailidou, Michalak, Mohammed, Molyneux, Mona Shehata, Nguyen, Pal, Pathania, Paul C. Boutros, Paul Waterhouse, Pei, Pellacani, Pirashaanthy Tharmapalan, Rajat Singhania, Rama Khokha, Reimand, Rios, Rios, Rugg-Gunn, Ruth Isserlin, Schimanski, Shackleton, Shannon, Shehata, Shiah, Shu, Sigl, Smith, Smyth, Stefan Hofer, Stefan Knapp, Stingl, Storey, Stunnenberg, Subramanian, Swneke Bailey, Thomas Kislinger, Tiago Medina, Tomasetti, van Amerongen, Van Keymeulen, Van Keymeulen, Visvader, Wang, Wojtowicz, Wuidart, Yu-Jia Shiah, Zhang   +111 more
core   +2 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Exposing The Cancer Genome Atlas (TCGA) as a SPARQL endpoint [PDF]

, 2011
Automated discovery of candidate biomarkers from multiple databases has been the central challenge in the Life Sciences in general and in the study of systemic processes such as those documented by The Cancer Genome Atlas (TCGA) in particular. &
Helena Deus
core   +2 more sources

Systems biology and cancer stem cells [PDF]

Journal of Cellular and Molecular Medicine, 2007
Introduction Molecular profiling for cancer classification Molecular profiling of cancer stem cells Emerging technologies for proteome characterization Biomolecular networks in cancer Perspective and concluding remarks AbstractThe identification, purification and characterization of cancer stem cells (CSCs) holds tremendous promise for improving the
Price, Nathan D, Foltz, Greg, Madan, Anup, Hood, Leroy, Tian, Qiang   +4 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Integration of proteomics into systems biology of cancer [PDF]

WIREs Systems Biology and Medicine, 2012
AbstractDeciphering the complexity and heterogeneity of cancer, benefits from integration of proteomic level data into systems biology efforts. The opportunities available as a result of advances in proteomic technologies, the successes to date, and the challenges involved in integrating diverse datasets are addressed in this review.
S, Hanash, M, Schliekelman, Q, Zhang, A, Taguchi   +3 more
openaire   +2 more sources