Results 81 to 90 of about 990,872 (342)

Spatial-temporal dynamics of a microbial cooperative behavior resistant to cheating

Nature Communications, 2022
Bacteria often live in densely packed, spatially-structured communities; however, much of our understanding of their behavior stems from studies in liquid culture. Here, Monaco et al.
Hilary Monaco, Kevin S. Liu, Tiago Sereno, Maxime Deforet, Bradford P. Taylor, Yanyan Chen, Caleb C. Reagor, Joao B. Xavier   +7 more
doaj   +1 more source

Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis [PDF]

, 2016
: This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes.
Alipour, Zeinab, Assadi, Majid, Ghasemi, Mojtaba, Nabipour, Iraj, Omrani, Abdolmajid   +4 more
core   +1 more source

GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization

, 2018
Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists' capability to discover functional relevance of their experiment design. While elucidating gene set
Chen, Hung-I Harry, Chen, Yidong, Chiu, Yu-Chiao, Huang, Yufei, Zhang, Songyao, Zhang, Tinghe   +5 more
core   +3 more sources

Rac1 drives intestinal stem cell proliferation and regeneration [PDF]

, 2013
Adult stem cells are responsible for maintaining the balance between cell proliferation and differentiation within self-renewing tissues. The molecular and cellular mechanisms mediating such balance are poorly understood.
Alessandro Scopelliti, Amcheslavsky, Ashton, Biteau, Brand, Buchon, Buchon, Choi, Cordero, el Marjou, Ellenbroek, Hochmuth, Ito, Jiang, Julia Cordero, Kevin Myant, Kitagishi, Marcos Vidal, Micchelli, Miyamoto, Myant, Ohlstein, Owen Sansom, Owusu-Ansah, Radtke, Sara Haque, Tothova, Tsatmali, Walmsley   +28 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response

, 2019
Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate ...
Bocci, Federico, Deng, Youyuan, Jia, Dongya, Jolly, Mohit Kumar, Levine, Herbert, Li, Xuefei, Onuchic, Jose N., Tripathi, Shubham   +7 more
core   +1 more source

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. [PDF]

, 2018
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female.
Abe, Akalin, Alison E. Casey, Ankit Sinha, Asselin-Labat, Buenrostro, Cardiff, Cerami, Cheryl Arrowsmith, Chlebowski, Cox, Cox, Dalia Barsyte-Lovejoy, Daniel De Carvalho, Deugnier, Dos Santos, Edgar, Eirew, Eirew, Eisen, Erik Drysdale, Gary Bader, Gascard, Genevieve Deblois, Gu, Hal Berman, Heinz, Hennighausen, Herschkowitz, Hu, Hui Fang, Huston, Hyeyeon Kim, Ignatchenko, Jackson, Jennifer Cruickshank, Joshi, Joshi, Joshi, Julie Livingstone, Kaltenborn, Kauff, Kelsey, Kendrick, Kiechl, Kislinger, Koboldt, Kotsopoulos, Krueger, Kucera, Labarge, Li, Lim, Lim, Lin, Loenen, Lucas, Lydon, Marotti, Maruyama, Mathieu Lupien, McLean, Meissner, Merico, Michailidou, Michalak, Mohammed, Molyneux, Mona Shehata, Nguyen, Pal, Pathania, Paul C. Boutros, Paul Waterhouse, Pei, Pellacani, Pirashaanthy Tharmapalan, Rajat Singhania, Rama Khokha, Reimand, Rios, Rios, Rugg-Gunn, Ruth Isserlin, Schimanski, Shackleton, Shannon, Shehata, Shiah, Shu, Sigl, Smith, Smyth, Stefan Hofer, Stefan Knapp, Stingl, Storey, Stunnenberg, Subramanian, Swneke Bailey, Thomas Kislinger, Tiago Medina, Tomasetti, van Amerongen, Van Keymeulen, Van Keymeulen, Visvader, Wang, Wojtowicz, Wuidart, Yu-Jia Shiah, Zhang   +111 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers

Nature Communications, 2017
There is an urgent need to identify predictive markers for selecting responders to immunotherapy. Here, the authors describe a transcriptional predictor of immunotherapy response and assess it in genomic data from ~ 10,000 human tissues across 30 ...
Chan-Young Ock, Jun-Eul Hwang, Bhumsuk Keam, Sang-Bae Kim, Jae-Jun Shim, Hee-Jin Jang, Sarang Park, Bo Hwa Sohn, Minse Cha, Jaffer A. Ajani, Scott Kopetz, Keun-Wook Lee, Tae Min Kim, Dae Seog Heo, Ju-Seog Lee   +14 more
doaj   +1 more source

Borges Dilemma, Fundamental Laws, and Systems Biology [PDF]

, 2007
I reason here that the known folk law in biology that there is no general law in biology because of exceptions is false. The (quantitative) systems biology offers the potential to solve the Borges Dilemma, by transcending it.
Ao, P
core   +3 more sources