Results 141 to 150 of about 15,755,427 (366)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

TRIM28 in cancer and cancer therapy

Frontiers in Genetics
TRIM28 (tripartite motif protein 28) was initially believed to be a transcription inhibitor that plays an important role in DNA damage repair (DDR) and in maintaining cancer cellular stemness. As research has continued to deepen, several studies have found that TRIM28 not only has ubiquitin E3 ligase activity to promote degradation of substrates, but ...
Kailang Li, Haifeng Wang, Bitao Jiang, Xiaofeng Jin   +3 more
openaire   +3 more sources

Solitary bone metastasis to the tibia from colorectal cancer- A case report [PDF]

, 2014
The onset of osseous metastases during the course of colorectal cancer is not common. Although rare, they usually appear in the axial skeleton. In our report, we refer to the case of a 48-year-old patient who presented with colon cancer and eventually ...
Alnajjar, Abdulsalam; Department of Medical oncology, Kuwait Cancer Control Centre, Safat, Kuwait., Mohanty, Asit Kumar; Department of Medical oncology, Kuwait Cancer Control Centre, Safat, Kuwait.   +1 more
core   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Iron therapy and cancer [PDF]

Kidney International, 1999
Anemia in cancer patients has many etiologies. Iron therapy clearly is indicated in patients whose anemias are associated with iron deficiency. However, a frequent cause of anemia in cancer is the "anemia of chronic disorders," in which, although functional iron may be low, tissue iron remains normal or high.
openaire   +2 more sources

Node-positive breast cancer: Which are the best chemotherapy regimens? [PDF]

, 2008
Breast cancer-associated mortality has been significantly reduced since the 1990s, mainly because of early diagnosis and systemic therapeutic interventions.
Bauerfeind, Ingo, Rack, Brigitte, Harbeck, Nadia, Friese, Klaus, Janni, Wolfgang, Sommer, Harald, Janni, Wolfgang;Rack, Brigitte;Harbeck, Nadja;Bauerfeind, Ingo;Sommer, Harald;Friese, Klaus   +6 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Effect of interfractional shoulder motion on low neck nodal targets for patients treated using volume modulated arc therapy (VMAT) [PDF]

, 2014
Purpose: To quantify the dosimetric impact of interfractional shoulder motion on targets in the low neck for head and neck patients treated with volume modulated arc therapy (VMAT).Methods: Three patients with head and neck cancer were selected.
Casey, Kevin; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Tung, Samuel; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Rosenthal, David; Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Wang, Pei-Fong; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.   +3 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Cancer Trends: Cancer of unknown primary

, 2019
Between 2012 and 2016, over 450 patients per year were diagnosed with a malignant cancer where the primary site of their cancer was unspecified. These cancers were identified by the presence of metastatic disease where the cancer has spread to other ...
National Cancer Registry Ireland (NCRI)
core