Results 121 to 130 of about 1,972,453 (318)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Epigenetic cancer therapy

, 2015
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers ...
Gray, Steven G.
core  

A systematic review of guided imagery as an adjuvant cancer therapy

, 2004
Aim: The aim of this paper is to summarise and critically evaluate the evidence available from controlled clinical trials regarding the use of guided imagery as a sole adjuvant therapy for cancer patients.
Roffe, L., Ernst, E., Schmidt, K.
core   +1 more source

TGF-β1 stimulates epithelial–mesenchymal transition and cancer-associated myoepithelial cell during the progression from in situ to invasive breast cancer

Cancer Cell International, 2019
Background The progression of ductal carcinoma in situ (DCIS) into invasive ductal carcinoma (IDC) is prevented by normal breast myoepithelial cells. Studies have suggested that EMT-associated genes were enriched in IDC in contrast to DCIS.
Li Wang, Cong Xu, Xia Liu, Yang Yang, Lu Cao, Guomin Xiang, Fang Liu, Shuling Wang, Jing Liu, Qingxiang Meng, Jiao Jiao, Yun Niu   +11 more
doaj   +1 more source

CANCER AND SERUM-THERAPY [PDF]

The American Journal of the Medical Sciences, 1895
n ...
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance.

, 2020
PURPOSE: Advanced breast cancer (ABC) has not been subjected to the same degree of molecular scrutiny as early primary cancer. Breast cancer evolves with time and under the selective pressure of treatment, with the potential to acquire mutations with ...
Hubank, M, Jamal, S, Herrera-Abreu, MT, Lopez-Knowles, E, Cutts, RJ, Osin, P, Ring, A, Pearson, A, Pascual, J, Walker, BA, Garcia-Murillas, I, Parton, M, Fribbens, C, Dowsett, M, Proszek, P, Shamsher, MK, Gonzalez De Castro, D, Johnston, SRD, Bye, H, Yuan, L, Schuster, EF, Turner, NC, Kingston, B, Nerurkar, A, Okines, AFC, O'Leary, B   +25 more
core   +1 more source

A Pax7::Foxo1 conditional mouse strain

Skeletal Muscle
Background The PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma (aRMS) is both understudied and an unmet clinical need. The biology of PAX7::FOXO1 aRMS is significantly different than PAX3::FOXO1 aRMS, presenting an opportunity to gain biological ...
G. Roger Askew, Jonathan Gauntlett, Katherine Brechun, Harald Kranz, Nicholas Salters, Jess D. Tate, Ellen Wang, Cassie Badger, Shireen Elhabian, Jared Schnider, Gillian St. John, Samuel V. Rasmussen, Narendra Bharathy, Charles Keller   +13 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Investigating dosimetric effect of rotational setup errors in IMPT planning of synchronous bilateral lung cancer

, 2015
Purpose: The purpose of this study is to evaluate the dosimetric effect of rotational setup errors on the synchronous bi-lateral lung cancer plans generated by the intensity modulated proton therapy (IMPT) technique.Methods: The original IMPT plans were ...
Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, Larson, Gary; Department of Radiation Oncology, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, Vargas, Carlos; Radiation Oncology, Proton Collaborative Group (PCG), Warrenville, Illinois, Dunn, Megan; Radiation Oncology, Proton Collaborative Group (PCG), Warrenville, Illinois, Zhang, Yongbin; Department of Medical Physics, Scripps Proton Therapy Center, San Diego, California, Zheng, Yuanshui; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Oklahoma   +5 more
core   +1 more source