Results 111 to 120 of about 1,972,453 (318)

The indication of palliative whole-brain radiotherapy for patients with brain metastases: a simple prognostic scoring system in the era of stereotactic radiosurgery

BMC Cancer
Background Stereotactic irradiation has become the mainstay treatment for brain metastases (BM), and whole-brain radiotherapy (WBRT) is often used for symptom palliation.
Toshiaki Hirose, Shoichi Deguchi, Kazuaki Yasui, Minoru Inoue, Tsuyoshi Onoe, Hirofumi Ogawa, Hirofumi Asakura, Koichi Mitsuya, Hideyuki Harada, Shigeyuki Murayama, Nakamasa Hayashi, Tetsuo Nishimura, Ryuta Saito   +12 more
doaj   +1 more source

Development of a high-precision bladder hyperthermic intracavitary chemotherapy device for bladder cancer and pharmacokinetic study

BMC Urology, 2019
Background Bladder hyperthermic intracavitary chemotherapy (HIVEC) has good effectiveness for bladder cancer, but conventional HIVEC systems lack precision and convenient application.
Mingchen Ba, Shuzhong Cui, Hui Long, Yuanfeng Gong, Yinbing Wu, Kunpeng Lin, Yinuo Tu, Bahuo Zhang, Wanbo Wu   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IL-2 and IL-12 in thyroid cancer: Clinical implication

, 2018
Purpose: The roles of IL-2 and IL-12, in different malignancies have been looked for since years. But very few studies have elucidated their role in thyroid tumorigenesis. Hence, present study sought to explore their utility in thyroid cancer, mainly the
Patel, Girish; Retired Senior Scientific Officer, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), NCH Compound, Asarwa, Ahmedabad-380 016, India, Kobawala, Toral; Research Assistant, Tumor Biology Lab-2, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), NCH Compound, Asarwa, Ahmedabad-380 016, India, Ghosh, Nandita; Assistant Professor and In-charge, Tumor Biology Lab-2, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), NCH Compound, Asarwa, Ahmedabad-380 016, India, Trivedi, Trupti; Senior Scientific Officer, Clinical Carcinogenesis Lab-3, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), NCH Compound, Asarwa, Ahmedabad-380 016, India, Gajjar, Kinjal; Junior Research Assistant, Tumor Biology Lab-2, Department of Cancer Biology, The Gujarat Cancer & Research Institute (GCRI), NCH Compound, Asarwa, Ahmedabad-380 016, India   +4 more
core   +1 more source

Enhancing mesothelin CAR T cell therapy for pancreatic cancer with an oncolytic herpes virus boosting CAR target antigen expression

Cancer Immunology, Immunotherapy
Mesothelin (MSLN) is a prominent target antigen for CAR T cell therapy due to its extensive expression in various solid tumors, including pancreatic cancer.
Mona Alhussein Aboalela, Mohamed Abdelmoneim, Shigeru Matsumura, Ibrahim Ragab Eissa, Itzel Bustos-Villalobos, Patricia Angela Sibal, Yu Orikono, Yuhei Takido, Yoshinori Naoe, Hideki Kasuya   +9 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Adherence to adjuvant therapy in post-menopausal breast cancer patients: A review

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, IncThis review aimed to address the concept of adherence to adjuvant therapy in post-menopausal women.
Banning, M, M. BANNING
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Ovarian Cancer Therapy

Cold Spring Harbor Perspectives in Medicine
Significant advances in basic and translational research have improved our understanding of the molecular alterations and biological vulnerabilities of the different histologic subsets of epithelial ovarian cancer (EOC). This has led to clinical trials that have incorporated novel agents based on molecular aspects into the treatment paradigm for both ...
Miao, Diana, Matulonis, Ursula A., Porter, Rebecca L.   +2 more
openaire   +2 more sources

Hyperthermia in Cancer Therapy

Journal of UOEH, 1984
Hyperthermia is being re-evaluated and currently used in the treatment of malignant tumor. There have been numerous in vitro and in vivo experimental data presented which confirm the selective heat damage on malignant cells. This review will attempt to summarize the information on experimental and clinical reports concerning hyperthermia.
H, Kawahara, S, Odagiri, H, Fujita, T, Nagano, M, Murakami   +4 more
openaire   +2 more sources