Results 131 to 140 of about 1,972,453 (318)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Effect of interfractional shoulder motion on low neck nodal targets for patients treated using volume modulated arc therapy (VMAT)

, 2014
Purpose: To quantify the dosimetric impact of interfractional shoulder motion on targets in the low neck for head and neck patients treated with volume modulated arc therapy (VMAT).Methods: Three patients with head and neck cancer were selected.
Casey, Kevin; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Tung, Samuel; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Rosenthal, David; Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Wang, Pei-Fong; Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.   +3 more
core   +1 more source

The integration of MRI in radiation therapy: collaboration of radiographers and radiation therapists

Journal of Medical Radiation Sciences, 2017
The increased utilisation of magnetic resonance imaging (MRI) in radiation therapy (RT) has led to the implementation of MRI simulators for RT treatment planning and influenced the development of MRI‐guided treatment systems.
Robba Rai, Shivani Kumar, Vikneswary Batumalai, Doaa Elwadia, Lucy Ohanessian, Ewa Juresic, Lynette Cassapi, Shalini K. Vinod, Lois Holloway, Paul J. Keall, Gary P. Liney   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cardiotoxicity and cancer therapy

, 2014
A fundamental concept of treatment is to do no harm. However, with cancer treatment this is not always possible. Chemotherapy is associated with cardiovascular (CV) complications.1,2 This risk is even greater in the elderly patients and patients with ...
Mikhailidis, DP, Vasiliadis, I, Kolovou, G   +2 more
core  

Correction: Feasibility of linac-based fractionated stereotactic radiotherapy and stereotactic radiosurgery for patients with up to ten brain metastases

Radiation Oncology, 2023
Masanori Hirata, Kazuaki Yasui, Naofumi Oota, Hirofumi Ogawa, Tsuyoshi Onoe, Sayo Maki, Yusuke Ito, Kenji Hayashi, Hirofumi Asakura, Shigeyuki Murayama, Koichi Mitsuya, Shoichi Deguchi, Katsumasa Nakamura, Nakamasa Hayashi, Tetsuo Nishimura, Hideyuki Harada   +15 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dose-to-medium vs. dose-to-water: Dosimetric evaluation of dose reporting modes in Acuros XB for prostate, lung and breast cancer

, 2014
Purpose: Acuros XB (AXB) dose calculation algorithm is available for external beam photon dose calculations in Eclipse treatment planning system (TPS). The AXB can report the absorbed dose in two modes: dose-to-water (Dw) and dose-to-medium (Dm).
Pokharel, Shyam; Department of Radiation Oncology, 21st Century Oncology, Naples, Florida, USA, Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA   +1 more
core   +1 more source

Effects of intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) on survival benefits and poor prognostic factors in patients with cervical cancer

BioMedical Engineering OnLine
Objective This study aimed to explore the influencing factors of survival benefit and poor prognosis of cervical cancer patients under different radiotherapy modalities.
Meili Li, Xiuhong Wu, Xiang Liu, Meiru Wen   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source