Results 91 to 100 of about 15,755,427 (366)

Macrophage Transcriptomic Alterations Driven by Alphavirus-Based Cancer Immunotherapy Vectors

Journal of Immunology Research
Cancer cells promote the polarisation of tumour-associated macrophages (TAMs) into pro-tumorigenic M2-like phenotype, contributing to cancer progression. Reprogramming TAMs by viral immunotherapy vectors represents a promising strategy for cancer therapy.
Ksenija Korotkaja, Darija Lapina, Zhanna Rudevica, Anna Zajakina   +3 more
doaj   +1 more source

Molecular profiling of advanced malignancies guides first-line N-of-1 treatments in the I-PREDICT treatment-naïve study

Genome Medicine, 2021
Background Malignancies are molecularly complex and become more resistant with each line of therapy. We hypothesized that offering matched, individualized combination therapies to patients with treatment-naïve, advanced cancers would be feasible and ...
Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Hitendra Patel, Mina Nikanjam, Paul T. Fanta, Michael E. Hahn, Pradip De, Casey Williams, Jessica Guido, Benjamin M. Solomon, Rana R. McKay, Amy Krie, Sarah G. Boles, Jeffrey S. Ross, J. Jack Lee, Brian Leyland-Jones, Scott M. Lippman, Razelle Kurzrock   +18 more
doaj   +1 more source

Drug repurposing for cancer therapy

Signal Transduction and Targeted Therapy
Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy ...
Ying Xia, Ming Sun, Hai Huang, W. Jin
semanticscholar   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

Immunotoxin therapy of cancer [PDF]

Nature Reviews Cancer, 2006
Rationally designed anticancer agents that target cell-surface antigens or receptors represent a promising approach for treating cancer patients. However, antibodies that bind these targets are often, by themselves, non-cytotoxic. By attaching potent toxins we can dramatically improve the clinical utility of some anti-tumour antibodies.
Pastan, Ira, Hassan, Raffit, FitzGerald, David J., Kreitman, Robert J.   +3 more
openaire   +2 more sources

Targeting cytokine and chemokine signaling pathways for cancer therapy

Signal Transduction and Targeted Therapy
Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer.
Ming Yi, Tian-Ye Li, Mengke Niu, Haoxiang Zhang, Yuze Wu, Kongming Wu, Zhi-Tang Dai   +6 more
semanticscholar   +1 more source

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Molecular Cancer, 2019
Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance.
Xinming Jing, Fengming Yang, C. Shao, Ke Wei, Meng-Yan Xie, Hua Shen, Y. Shu   +6 more
semanticscholar   +1 more source

Natural Products in Cancer Therapy: Past, Present and Future

Natural Products and Bioprospecting, 2021
Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century.
Min Huang, Jin-Jian Lu, Jian Ding
semanticscholar   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

MRI and DWI: the future in cervical cancer? [PDF]

, 2013
This article is an editorial, and it doesn't include an abstract. Full text of this article is available in HTML and PDF.Cite this article as:Marconi D, Rauber E, Soares P. MRI and DWI: the future in cervical cancer?
Soares, Paula de Cassia; Department of Radiation Oncology, Barretos Cancer Hospital, Brazil., Marconi, Daniel Grossi; Department of Radiation Oncology, Barretos Cancer Hospital, Brazil., Rauber, Erick; Department of Radiation Oncology, Barretos Cancer Hospital, Brazil.   +2 more
core   +1 more source