Results 81 to 90 of about 15,755,427 (366)

Radiobiological model-based approach to determine the potential of dose-escalated robust intensity-modulated proton radiotherapy in reducing gastrointestinal toxicity in the treatment of locally advanced unresectable pancreatic cancer of the head

Radiation Oncology, 2020
Background The purpose of this study was to determine the potential of escalated dose radiation (EDR) robust intensity-modulated proton radiotherapy (ro-IMPT) in reducing GI toxicity risk in locally advanced unresectable pancreatic cancer (LAUPC) of the ...
Vijay P. Raturi, Hidehiro Hojo, Kenji Hotta, Hiromi Baba, Ryo Takahashi, Toshiya Rachi, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Hidenobu Tachibana, Takaki Ariji, Kana Motegi, Masaki Nakamura, Masayuki Okumura, Yasuhiro Hirano, Tetsuo Akimoto   +15 more
doaj   +1 more source

High DCR and Better Survival in Patients with Advanced or Metastatic Gastric Cancer Receiving Anti-Angiogenic TKI plus Chemotherapy: A Real-World Study

Technology in Cancer Research & Treatment, 2023
Objectives: This study was carried out to assess the efficacy and drug toxicity of anti-angiogenic tyrosine kinase inhibitor (TKI) plus chemotherapy as second-line or above therapeutic regime in advanced or metastatic gastric cancer patients.
Caiyun Nie MD, Huifang Lv MD, Beibei Chen MD, Weifeng Xu MD, Jianzheng Wang MD, Saiqi Wang MD, Yingjun Liu MD, Yunduan He MD, Jing Zhao MD, Xiaobing Chen MD   +9 more
doaj   +1 more source

Targeting apoptosis in cancer therapy

Nature Reviews Clinical Oncology, 2020
For over three decades, a mainstay and goal of clinical oncology has been the development of therapies promoting the effective elimination of cancer cells by apoptosis.
B. Carneiro, W. El-Deiry
semanticscholar   +1 more source

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Signal Transduction and Targeted Therapy, 2021
Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Rui-Xue Huang, P. Zhou
semanticscholar   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Long-term effectiveness of adjuvant Goserelin in premenopausal women with early breast cancer [PDF]

, 2009
BACKGROUND: Systematic reviews have found that luteinizing hormone-releasing hormone (LHRH) agonists are effective in treating premenopausal women with early breast cancer.
Fornander, T, S. Forsyth, Johansson, Ulla,, T. Fornander, U. Johansson, Reczko, Krystyna,, B. Nordenskjold, Nordenskjold, Bo, Fornander, Tommy,, K. Reczko, Reczko, Krystyna, Fohlin, H, Hackshaw, Allan, Fornander, Tommy, Fohlin, Helena,, Valentini, Miriam,, H. Fohlin, Sainsbury, R, Fohlin, Helena, Johansson, U, Monson, Kathryn,, Reczko, K, M. Valentini, Forsyth, Sharon, Sainsbury, Richard,, Nicolucci, A, Monson, K, R. Sainsbury, Baum, M, Sainsbury, Richard, Valentini, Miriam, A. Hackshaw, Nordenskjöld, Bo,, Forsyth, Sharon,, M. Baum, A. Nicolucci, Nordenskjold, B, Fornander, T,, K. Monson, Johansson, Ulla, Nicolucci, Antonio,, Baum, Michael,, Baum, Michael, Hackshaw, Allan,, Hackshaw, A, Valentini, M, Monson, Kathryn, Nicolucci, Antonio, Forsyth, S   +48 more
core   +2 more sources

Treatment outcomes of passive scattering proton beam therapy for stage I non-small cell lung cancer

Radiation Oncology, 2021
Introduction To investigate the treatment outcomes of passive scattering proton beam therapy using stereotactic ablative radiotherapy (SABR) or hypofractionated radiation therapy (RT) for inoperable patients or those who refused surgery for stage I non ...
Unurjargal Bayasgalan, Sung Ho Moon, Jong Hwi Jeong, Tae Hyun Kim, Kwan Ho Cho, Yang-Gun Suh   +5 more
doaj   +1 more source

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy

Molecular Cancer, 2021
Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose activation is necessary for cell division processes via regulation of mitosis.
R. Du, Chuntian Huang, Kangdong Liu, Xiang Li, Zigang Dong   +4 more
semanticscholar   +1 more source

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Dosimetric dependence on the collimator angle in prostate volumetric modulated arc therapy [PDF]

, 2014
Purpose: The purpose of this study is to investigate the dose-volume variations of planning target volume (PTV) and organs-at-risk (OARs) in prostate volumetric modulated arc therapy (VMAT) when varying collimator angle.
Rehman, Jalil ur; Department of Radiation Physics, UT MD Anderson Cancer Center, Houston, USA, Chow, James; Radiation Medicine Program, Princess Margaret Cancer Center, Toronto, Canada Department of Radiation Oncology, University of Toronto, Toronto, Canada, Isa, Muhammad; Department of Physics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan Radiation Medicine Program, Princess Margaret Cancer Center, Toronto, Canada, Afzal, Muhammad; Department of Physics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan   +3 more
core   +1 more source