Results 81 to 90 of about 1,972,453 (318)

Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy

Nature Communications
The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC).
Emmanuel C. Patin, Pablo Nenclares, Charleen Chan Wah Hak, Magnus T. Dillon, Anton Patrikeev, Martin McLaughlin, Lorna Grove, Shane Foo, Heba Soliman, Joao P. Barata, Joanna Marsden, Holly Baldock, Jim Gkantalis, Victoria Roulstone, Joan Kyula, Amy Burley, Lisa Hubbard, Malin Pedersen, Simon A. Smith, Eleanor Clancy-Thompson, Alan A. Melcher, Masahiro Ono, Antonio Rullan, Kevin J. Harrington   +23 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Journal of Proton Therapy: Call for Papers

, 2015
Journal of Proton Therapy (JPT) is an international open access, peer-reviewed journal, which publishes original research, technical reports, reviews, case reports, editorials, and other materials on proton therapy with focus on radiation oncology ...
Proton Therapy, Journal of
core  

MRI and DWI: the future in cervical cancer?

, 2013
This article is an editorial, and it doesn't include an abstract. Full text of this article is available in HTML and PDF.Cite this article as:Marconi D, Rauber E, Soares P. MRI and DWI: the future in cervical cancer?
Soares, Paula de Cassia; Department of Radiation Oncology, Barretos Cancer Hospital, Brazil., Marconi, Daniel Grossi; Department of Radiation Oncology, Barretos Cancer Hospital, Brazil., Rauber, Erick; Department of Radiation Oncology, Barretos Cancer Hospital, Brazil.   +2 more
core   +1 more source

TMEM160 promotes hepatocellular carcinoma cell proliferation, invasion, and immune evasion by regulating the VEGFA/PI3K/AKT signaling axis

Frontiers in Immunology
ObjectiveHepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality, and TMEM160 is potentially involved in tumor progression and immune escape.
Guodong Shi, Guodong Shi, Guodong Shi, Dehua Liu, Dehua Liu, Dehua Liu, Jinhan Qiao, Jinhan Qiao, Jinhan Qiao   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Clinical trends and outcomes of male breast cancer: Experience of a tertiary oncology centre in India

, 2014
Purpose: Because of its rarity in any oncology centre, the clinical trends of male breast cancer specific to its geographical distribution have remained relatively unexplored.
Mukherjee, Anindya; Department of Radiation Oncology, Medical College, Kolkata, Chattopadhyay, Subrata; Department of Radiation Oncology, Medical College, Kolkata, Sur, Prabir Kumar; Department of Radiotherapy, Hemalata Cancer Institute, Bhubaneswar,, Saha, Aramita; Department of Medical Oncology, Apollo Gleneagles Cancer Hospital   +3 more
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Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in PIK3CA-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers.

, 2021
Cyclin-dependent kinase 4/6 (CDK4/6) and PI3K inhibitors synergize in PIK3CA-mutant ER-positive HER2-negative breast cancer models. We conducted a phase Ib trial investigating the safety and efficacy of doublet CDK4/6 inhibitor palbociclib plus selective
Hubank, M, Prout, T, Finneran, L, Herrera-Abreu, MT, Ruddle, R, Cutts, RJ, Lopez, JS, Proszek, PZ, Hills, M, Ring, A, Pascual, J, Pearson, A, Garcia-Murillas, I, Hrebien, S, Turner, A, King, J, Armstrong, AC, Yap, TA, Macpherson, IR, Raynaud, FI, Malia, J, Hall, E, Turner, NC, Gevensleben, H, Parmar, M, Okines, AFC, Lim, JSJ, Swales, KE   +27 more
core   +1 more source

Targeted therapy in cancer [PDF]

Cancer Chemotherapy and Pharmacology, 2015
To describe the emergence of targeted therapies that have led to significant breakthroughs in cancer therapy and completed or ongoing clinical trials of novel agents for the treatment of patients with advanced cancer.The literature was systematically reviewed, based on clinical experience and the use of technologies that improved our understanding of ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source