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Chinese experts consensus on quality control standards for tumor organoids diagnosis and treatment platform (2022 version) [PDF]

Zhongguo aizheng zazhi, 2022
Recently, advances in organoid technology have opened new avenues for the development of novel models of human cancer. Patient-derived tumor organoids retain phenotypes such as histopathological, genetic and molecular features of the original tumor.
The Society of Cancer Multidisciplinary Diagnosis and Treatment, China Anti-Cancer Association, The Society of Cancer Endocrinology, China Anti-Cancer Association
doaj   +1 more source

Expert consensus on neoadjuvant treatment of breast cancer in China (2021 edition) [PDF]

Zhongguo aizheng zazhi, 2022
Neoadjuvant therapy has become one of the standard treatments in early breast cancer. In 2019, China breast cancer neoadjuvant therapy expert group discussed and expounded the purpose, indication, evaluation criteria, surgical operation principles and ...
Expert group of expert consensus on neoadjuvant treatment of breast cancer in China ( edition)
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Expert consensus on diagnosis, treatment and fertility management of young breast cancer patients

Journal of the National Cancer Center, 2021
Breast cancer in young females is a relatively common disease in China. Young breast cancer has aggressive clinical and pathological features. During the treatment of young females with breast cancer, issues involving the choice of surgical methods ...
Committee of Diagnosis, Treatment, and Fertility Management of Chinese Young Breast Cancer Patients
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DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors

Scientific Reports, 2023
Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene deletion/disruption (DNMT1 −/− ) on anticancer activity of a class of DNMTi in vitro, in vivo ...
Angelo B. A. Laranjeira, Melinda G. Hollingshead, Dat Nguyen, Robert J. Kinders, James H. Doroshow, Sherry X. Yang   +5 more
doaj   +1 more source

Rethinking Oncologic Treatment Strategies with Interleukin-2

Cells, 2023
High-dose recombinant human IL-2 (rhIL-2, aldesleukin) emerged as an important treatment option for selected patients with metastatic melanoma and metastatic renal cell carcinoma, producing durable and long-lasting antitumor responses in a small fraction
Brian Ko, Naoko Takebe, Omozusi Andrews, Monish Ram Makena, Alice P. Chen   +4 more
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Plasma in Cancer Treatment [PDF]

Cancers, 2020
Cancer is the second leading cause of death worldwide, and while science has advanced significantly to improve the treatment outcome and quality of life in cancer patients, there are still many issues with the current therapies, such as toxicity and the development of resistance to treatment [...]
Angela Privat-Maldonado, Annemie Bogaerts   +1 more
openaire   +3 more sources

Online adaptive radiotherapy for bladder cancer using a simultaneous integrated boost and fiducial markers

Radiation Oncology, 2023
Purpose The aim was to assess the feasibility of online adaptive radiotherapy (oART) for bladder cancer using a focal boost by focusing on the quality of the online treatment plan and automatic target delineation, duration of the workflow and performance
Sana Azzarouali, Karin Goudschaal, Jorrit Visser, Maarten Hulshof, Marjan Admiraal, Niek van Wieringen, Jakko Nieuwenhuijzen, Jan Wiersma, Laurien Daniëls, Duncan den Boer, Arjan Bel   +10 more
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TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

Journal of Hematology & Oncology, 2021
Background Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in
Sherry X. Yang, Melinda Hollingshead, Larry Rubinstein, Dat Nguyen, Angelo B. A. Larenjeira, Robert J. Kinders, Michael Difilippantonio, James H. Doroshow   +7 more
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The Patient's perspective on radiation therapy for anal cancer: Evaluation of expectations and stigma

Cancer Reports, 2023
Background Little is known regarding anal cancer patients' perspectives on undergoing radiation therapy. Additionally, the stigma surrounding anal cancer diagnosis warrants a better understanding of the barriers to complete disclosure in patient ...
Basil H. Chaballout, Eric M. Chang, Narek Shaverdian, Percy P. Lee, Phillip J. Beron, Michael L. Steinberg, Ann C. Raldow   +6 more
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Effects of MRE11 on Apoptosis and Proliferation of Esophageal Squamous Cancer Cells

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the effect of MRE11 on the proliferation and apoptosis of esophageal squamous cancer cells and its molecular mechanism. Methods MRE11 expression was downregulated by MRE11 siRNA transfection in esophageal squamous cancer cells ...
ZHANG Yan, ZHANG Hongrui, MENG Dandan, YI Zhenying, XU Zhiqiao   +4 more
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