Results 131 to 140 of about 3,307,905 (304)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang +5 more
wiley +1 more source
Cancer Trends: Soft Tissue Sarcomas [PDF]
, 2014 Sarcomas are a group of uncommon cancers that originate from mesenchymal cells as opposed to more well-known cancers that develop from epithelial tissue.
National Cancer Registry Ireland (NCRI)
core
Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3
Advanced Science, EarlyView.This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao +6 more
wiley +1 more source
Pakistan Armed Forces Medical Journal, 2009 Vaccines are medicines that boost the immune system’s natural ability to protect the body against “foreign invaders” that may cause disease. Vaccines are composed of a suspension of attenuated or killed microorganisms (bacteria, viruses, or rickettsiae),
Azhar Mubarik
doaj +2 more sources
Cancer Trends: Cancers of the testis
, 2012 An average of 132 cases of testicular cancer was diagnosed per year in Ireland between 1994 and 2010 (Table 1). Almost all cases were microscopically verified (98%) and were germ-cell tumours—57% of which were seminomatous and 40% non-seminomatous ...
National Cancer Registry Ireland (NCRI)
core
Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy
, 2019 Cancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and ...
Zheyan Fang +4 more
core +1 more source
Advanced Science, EarlyView.This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng +9 more
wiley +1 more source
PharmaceuticsExtensive research into mRNA vaccines for cancer therapy in preclinical and clinical trials has prepared the ground for the quick development of immune-specific mRNA vaccines during the COVID-19 pandemic.
Theodora Katopodi +22 more
doaj +1 more source