Results 181 to 190 of about 3,308,693 (307)

Current evidence and insights on single vs. double dose of basiliximab in adult solid organ transplant recipients: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this systematic review was to assess all available clinical data regarding the use of a single dose of basiliximab in solid organ transplantation compared to the standard double dosage, with particular interest in efficacy, safety and cost‐savings.
Alessio Provenzani, Braidon A. Lape, Anneliese M. Harp, Victoria Weisbrod, Lavinia Piazza   +4 more
wiley   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

mRNA cancer vaccines: delivery strategies, immune modulation, and clinical translation. [PDF]

Front Pharmacol
Tian D, Li X, Yang Z, Zhao X, Hu Z, Zhao H, Du S, Liu S, Zhang L, Xu Y, Lu X.   +10 more
europepmc   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Cancer Vaccines in Genitourinary Malignancies: Current Advances and Future Directions. [PDF]

Vaccines (Basel)
Altay H, Al-Hashimi I, Matthews J, DeAlessandro G, Ghelani GH.   +4 more
europepmc   +1 more source

Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics. [PDF]

Signal Transduct Target Ther
Ye L, Zhao G, Ma J, Gan Q, Luo N, Pan D, Chen C, Chen X, Ning S.   +8 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Unusually long remission in two patients with follicular lymphoma receiving immunomodulating therapeutic cancer vaccines. [PDF]

Leuk Res Rep
Holmström MO, Ahmad SM, Klausen U, Bjørn ME, Gang AO, El-Galaly TC, Pedersen LM, Andersen MH.   +7 more
europepmc   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Editorial: Advances in therapeutic cancer vaccines-mechanisms and development. [PDF]

Front Immunol
George MM, Brennick CA, Moon JJ, Lihm J, Choi H.   +4 more
europepmc   +1 more source