Advanced Science, EarlyView.The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang +8 more
wiley +1 more source
Gene-modified spontaneous Epstein-Barr virus-transformed lymphoblastoid cell lines as autologous cancer vaccines: Mutated p21 ras oncogene as a model [PDF]
, 2000 Boris Kubuschok +7 more
openalex +1 more source
A Potent and Effective Suicidal Listeria Vaccine Platform. [PDF]
, 2019 Live-attenuated Listeria monocytogenes has shown encouraging potential as an immunotherapy platform in preclinical and clinical settings. However, additional safety measures will enable application across malignant and infectious diseases.
Benanti, Erin L +12 more
core
Novel Bivalent mRNA‐LNP Vaccine for Highly Effective Protection against Pneumonic Plague
Advanced Science, EarlyView.The study investigates mRNA‐lipid nanoparticle vaccines targeting Yersinia pestis, the causative agent of plague. Combined F1+LcrV mRNA vaccination elicited robust immune responses and protected mice against virulent wild‐type and atypical strains.
Uri Elia +12 more
wiley +1 more source
TGIF1 overexpression promotes glioma progression and worsens patient prognosis
Cancer Medicine, Volume 11, Issue 24, Page 5113-5128, December 2022., 2022 This study is the first to comprehensively analyze and reveal TGIF1, as a new oncogene, is closely related to the malignancy‐related phenotype of glioma, and that TGIF1 could be an independent risk factor for poor prognosis of glioma, which is expected to become a new target for individualized treatment of glioma patients.
Baoya Wang +5 more
wiley +1 more source
Clinical Landscape of Therapeutic Cancer Vaccines: Challenges and Opportunities
Xiehe Yixue ZazhiObjectiveTo explore the status and characteristics of clinical trials of therapeutic cancer vaccines, and provide the overall trend of clinical translational research of therapeutic cancer vaccines.MethodsThe ClinicalTrial registration platform was ...
LIU Shupeng +3 more
doaj +1 more source
105Ad7 cancer vaccine stimulates anti-tumour helper and cytotoxic T-cell responses in colorectal cancer patients but repeated immunisations are required to maintain these responses [PDF]
, 2000 Lindy G. Durrant +3 more
openalex +1 more source
Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B
Advanced Science, EarlyView.Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang +8 more
wiley +1 more source
Advances in exosome biomarkers for cervical cancer
Cancer Medicine, Volume 11, Issue 24, Page 4966-4978, December 2022., 2022 Cancer‐derived exosomes may promote CC metastasis by boosting cellular epithelial‐mesenchymal transformation (EMT), controlling the proliferation, invasion, or migration of cancer cells, as well as influencing immune escape and aiding angiogenesis.
Zihan Ran +5 more
wiley +1 more source
Oncolytic mechanisms and immunotherapeutic potential of Newcastle disease virus in cancer therapy [PDF]
arXivNewcastle Disease Virus (NDV), classified as Avian orthoavulavirus 1 (avian paramyxovirus type 1), is a promising oncolytic agent that selectively targets and destroys cancer cells while sparing normal tissues. Its oncoselectivity exploits cancer-specific defects in antiviral defenses, particularly impaired Type I interferon signaling, and dysregulated
arxiv