Results 301 to 310 of about 269,977 (355)

Revolutionizing adjuvant development: harnessing AI for next-generation cancer vaccines. [PDF]

open access: yesFront Immunol
Zhang WY   +5 more
europepmc   +1 more source

Synthesis of 2‐substituted ATP derivatives and their use in enzymatic synthesis and postsynthetic labelling of RNA

open access: yesChemBioChem, Accepted Article.
A series of adenosine triphosphate derivatives bearing chloro, fluoro, amino, methyl, vinyl and ethynyl groups at position 2 were synthesized and tested as substrates for RNA and DNA polymerases. The modified nucleotides worked well in in vitro transcription with T7 polymerase and primer extension (PEX) using engineered DNA polymerases (TGK, 2M) except
Ugnė Šinkevičiūtė   +5 more
wiley   +1 more source

PCFT Independent Cellular Uptake of Cyclic Cell Penetrating Peptide Conjugated Folic Acid

open access: yesChemBioChem, Accepted Article.
Folic acid is an essential component of many metabolic processes, including the synthesis of nucleoproteins, purines, and pyrimidines and is a recommended supplement to lower the incidence of various disorders. Folic acid and folate loaded nanoparticles are extensively evaluated for sustained release and enhanced stability of the molecule, however ...
Vineet Kumar Mishra   +3 more
wiley   +1 more source

Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens. [PDF]

open access: yesJ Biomed Sci
Chi WY   +11 more
europepmc   +1 more source

Synthesis, Antimycobacterial Activity and Computational Insight of novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates Against Multidrug‐Resistant M. tuberculosis

open access: yesChemMedChem, Accepted Article.
To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri   +6 more
wiley   +1 more source

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