Results 31 to 40 of about 20,990 (167)

Knockdown of cancerous inhibitor of protein phosphatase 2A may sensitize NSCLC cells to cisplatin [PDF]

Cancer Gene Therapy, 2014
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified human oncoprotein that can stabilize some proteins by inhibiting degradation mediated by protein phosphatase 2A (PP2A) and it increases the proliferation of several cancer cells.
L. Wei, W. Qu, J. Sun, X. Wang, L. Lv, L. Xie, X. Song   +6 more
semanticscholar   +3 more sources

Deregulation of protein phosphatase 2A inhibitor SET is associated with malignant progression in breast cancer [PDF]

Scientific Reports, 2021
Abstract To understand the mechanism underlying metastasis, identification of a mechanism-based and common biomarker for circulating tumour cells (CTCs) in heterogenous breast cancer is needed. SET, an endogenous inhibitor of protein phosphatase 2A, was overexpressed in all subtypes of invasive breast carcinoma ...
Katsunori Tozuka, Pattama Wongsirisin, Shigenori E. Nagai, Yasuhito Kobayashi, Miki Kanno, Kazuyuki Kubo, Ken Takai, Kenichi Inoue, Hiroshi Matsumoto, Yoshihito Shimizu, Masami Suganuma   +10 more
openaire   +4 more sources

3D model for Cancerous Inhibitor of Protein Phosphatase 2A armadillo domain unveils highly conserved protein-protein interaction characteristics.

Journal of Theoretical Biology, 2015
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is a human oncoprotein, which exerts its cancer-promoting function through interaction with other proteins, for example Protein Phosphatase 2A (PP2A) and MYC. The lack of structural information for CIP2A significantly prevents the design of anti-cancer therapeutics targeting this protein.
Käthe M. Dahlström, T. Salminen
semanticscholar   +3 more sources

siRNA-Mediated Silencing of CIP2A Enhances Docetaxel Activity Against PC-3 Prostate Cancer Cells [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an identified human oncoprotein which modulates malignant cell growth. It is overexpressed in human prostate cancer and in most of the human malignancies.
Saiedeh Razi Soofiyani, Akbar Mohammad Hoseini, Ali Mohammadi, Vahid Khaze Shahgoli, Behzad Baradaran, Mohammad Saeid Hejazi   +5 more
doaj   +1 more source

Prognostic value of CIP2A gene expression in adult Egyptian acute myeloid leukemia patients

Egyptian Journal of Medical Human Genetics, 2020
Background Protein phosphatase 2A (PP2A) functions as a tumor suppressor in many cancers. Cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibits PP2A proteolytic degradation of c-Myc and enhances cell growth and tumor formation in several tissues.
Roxan E. Shafik, Azza M. Ibrahim, Fadwa Said, Naglaa M. Hassan, Hanan E. Shafik, Hala A. Shokralla   +5 more
doaj   +1 more source

Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. [PDF]

, 2016
Prostate carcinogenesis involves alterations in several signaling pathways, the most prominent being the PI3K/AKT pathway. This pathway is constitutively active and drives prostate cancer (PCa) progression to advanced metastatic disease. PTEN, a critical
Chowdhary, Harshika, Colden, Melissa, Dahiya, Rajvir, Dar, Altaf A, Dasgupta, Pritha, Deng, Guoren, Greene, Kirsten, Hashimoto, Yutaka, Imai-Sumida, Mitsuho, Kato, Taku, Kulkarni, Priyanka, Majid, Shahana, Mitsui, Yozo, Nip, Hannah, Saini, Sharanjot, Shiina, Marisa, Tabatabai, Z Laura, Tanaka, Yuichiro, Varahram, Shahryari, Yamamura, Soichiro   +19 more
core   +2 more sources

Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment [PDF]

Cancer Biology & Therapy, 2013
Inhibitor 2 of protein phosphatase 2A (I2PP2A), a biological inhibitor of the cellular serine/threonine protein phosphatase PP2A, is associated with numerous cellular processes that often lead to the formation and progression of cancer. In this study we hypothesized that targeting the inhibition of I2PP2A's multiple functions in prostate cancer cells ...
Archana, Mukhopadhyay, Kayann, Tabanor, Rathnam, Chaguturu, Jane V, Aldrich   +3 more
openaire   +2 more sources

Protein phosphatase 2A as a therapeutic target in acute myeloid leukemia [PDF]

, 2016
Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described.
Adachi, Agarwal, Al-Murrani, Arnaud, Arnold, Barragan, Blalock, Blalock, Bononi, Bryan, Calin, Cancer Genome Atlas Research Network, Canela, Cervoni, Chen, Chen, Chen, Cheng, Christensen, Ciccone, Cohen, Come, Cristobal, Cristobal, Cristobal, Cristobal, Cristobal, Dohner, Dong, Eichhorn, Esplin, Estella-Hermoso de Mendoza, Fan, Gallay, Gao, Grallert, Haesen, Ingwersen, Irie, Janghorban, Janssens, Jin, Junttila, Kalla, Kalousi, Kandilci, Kelly, Khanna, Khanna, Kuo, Kutney, Lambrecht, Letourneux, Leulliot, Li, Liu, Longin, Low, Lucas, Lucas, Luo, Ma, Marcucci, Margolis, Mumby, Naetar, Neviani, Neviani, Neviani, Niemela, Oaks, Ofran, Perot, Perrotti, Perrotti, Pippa, Price, Ramaswamy, Roberts, Rorick, Rowe, Ruediger, Ruediger, Ruvolo, Ruvolo, Ruvolo, Ruvolo, Sablina, Sablina, Saddoughi, Saito, Schonthal, Seeling, Seo, Seshacharyulu, Seval, Shah, Shouse, Shouse, Switzer, ten Klooster, Trotta, Trotta, Turowski, Vasudevan, Wang, Wang, Wang, Westermarck, Wong, Xu, Xue, Yan, Yang, Yang, Yohe, Yu, Zwaenepoel   +117 more
core   +3 more sources

OCT4 Represses Inflammation and Cell Injury During Orchitis by Regulating CIP2A Expression

Frontiers in Cell and Developmental Biology, 2021
Octamer-binding transcription factor 4 (OCT4) and cancerous inhibitor of protein phosphatase 2A (CIP2A) are upregulated in testicular cancer and cell lines.
Ruifeng Zeng, Chengli Jin, Chuchu Zheng, Shaoqi Li, Siyue Qian, Jingsa Pan, Lvhe Wang, Junfeng Zhao, Le Qin   +8 more
doaj   +1 more source

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core   +1 more source