Results 51 to 60 of about 20,990 (167)

Reciprocal regulation of CIP2A and AR expression in prostate cancer cells

Discover Oncology, 2022
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein overexpressed in human malignancies, including prostate cancer (PCa). In this study, we aimed to explore the oncogenic function of CIP2A in PCa cells and its underlying mechanism. We
Hao-Wen Chuang, Jian-Hua Pan, Yi-Xuan Cai, Darius Rupa, Ting-Syuan Huang, Tzu-Chien Kuo, Chiao-Wen Lin, Chi-Wei Chen, Chia-Chin Lin, Herng-Sheng Lee, Ta-Chun Yuan   +10 more
doaj   +1 more source

FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model [PDF]

, 2017
Background: Malignant mesothelioma (MM) is a very aggressive type of cancer, with a dismal prognosis and inherent resistance to chemotherapeutics. Development and evaluation of new therapeutic approaches is highly needed.
Agata Szymiczek, Andrea Napolitano, Carlotta Giorgi, David Larson, Giovanni Gaudino, Haining Yang, Harvey I. Pass, Hideki Furuya, Jiaming Xue, Laura Pellegrini, Michele Carbone, Mika Tanji, Paolo Pinton, Sandra Pastorino, Shuangjing Li, Yasutaka Takinishi   +15 more
core   +3 more sources

Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk [PDF]

, 2018
β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription.
Bhardwaj, Deepshikha, Cantí Nicolás, Carles, Coopman, PJ, Crespí Sallán, Marta, Herreros Danés, Judit, Nàger Grifo, Mireia, Visa Pretel, Anna   +6 more
core   +3 more sources

INVESTIGATION OF SALİVARY MIR-9 AND SERUM CIP2A LEVELS IN FANCONI ANEMIA PATIENTS AT HIGH RISK OF DEVELOPING ORAL SQUAMOUS CELL CARCINOMA

Hematology, Transfusion and Cell Therapy, 2023
Objective: Fanconi anemia (FA) is a rare bone marrow failure syndrome caused by mutations in DNA repair genes, and the risk of developing Oral Squamous Cell Carcinoma (OSCC) in FA patients is higher than in the normal population and is seen at younger ...
Zişan Asal Kılıç, Çetin Timur, Tülin Tiraje Celkan, Şahin Öğreden, Nevin Yalman   +4 more
doaj   +1 more source

Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

Molecules, 2019
Non-small cell lung cancer (NSCLC) patients carrying an epidermal growth factor receptor (EGFR) mutation are initially sensitive to EGFR-tyrosine kinase inhibitors (TKIs) treatment, but soon develop an acquired resistance.
Pengfei Liu, Yuchen Xiang, Xuewen Liu, Te Zhang, Rui Yang, Sen Chen, Li Xu, Qingqing Yu, Huzi Zhao, Liang Zhang, Ying Liu, Yuan Si   +11 more
doaj   +1 more source

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]

, 2017
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson, Anthony, Barnes, Boehm, Boisvert, Bos, Campbell, Cantley, Capes-Davis, Caserta, Clevers, Corbalán-García, Crossman, Deevi, Deevi, Dubois, Dubois, Durgan, Décaillot, Eisenmann, Enslen, Eroglu, Furia, Ge, Glover, Hanahan, Hao, Hietakangas, Irazoqui, Jaffe, Jagan, Jagan, Jia, Johnston, Klompstra, Kovacs, Kumari, Lee, Lee, Leslie, Li, Lima-Fernandes, Lima-Fernandes, Liu Tj, Luttrell, Ma, Magudia, Maier, Martin-Belmonte, Meitinger, Meuillet, Misticone, Morin, Nagasaki, Naguib, Naguib, Narbonne, Noda, Ogg, Oh, Pertz, Pálmer, Raftopoulou, Raftopoulou, Rahdar, Rock, Rouault, Salmena, Sanchez, Sato, Shukla, Slorach, Smith, Song, Song, Söderberg, Tait, Torres, Ueda, Urs, Walker, Weng, Yun   +82 more
core   +3 more sources

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]

, 2015
Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B., Haferkamp, S., Hufnagel, A.L., Kneitz, S., Leikam, C., Meierjohann, S., Murphy, D.J., Mühling, B., Nanda, I., Otto, C., Schartl, M., Schmid, M., Wagner, T.U.   +12 more
core   +2 more sources

Prognostic value of the NLR combined with CIP2A in the serum of patients with colorectal cancer

BMC Surgery, 2021
Objective This study aimed to investigate the prognostic value of CIP2A (cancerous inhibitor of protein phosphatase 2A) and the NLR (neutrophil–lymphocyte ratio) in the serum of patients with CRC (colorectal cancer) after resection.
Wei Chen, Hong-Jun Yi, Xiao-Qiong Chen, Wan-Zhen Xie, Xing-kui Tang, Jun-Wen Ye, Xiang Peng, Yan Zhang, Jing-Lin Liang, Mei-Jin Huang   +9 more
doaj   +1 more source

Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer [PDF]

, 2015
© 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. Funded by Friends of ANCHOR NHS Grampian Endowment Fund.
Cao, Lin, Chan, Wanhei, Heys, Steven D, Liu, Jiaen, McCaig, Colin D, Milne, Gillian, Pu, Jin, Xu, Yanjie, Yang, Bo   +8 more
core   +1 more source

Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progressionResearch in context

EBioMedicine, 2019
Background: Triple-negative breast cancer (TNBC) remains difficult to be targeted. SET and cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting inhibitors of protein phosphatase 2A (PP2A) and frequently overexpressed in
Chun-Yu Liu, Tzu-Ting Huang, Yi-Ting Chen, Ji-Lin Chen, Pei-Yi Chu, Chun-Teng Huang, Wan-Lun Wang, Ka-Yi Lau, Ming-Shen Dai, Chung-Wai Shiau, Ling-Ming Tseng   +10 more
doaj   +1 more source