ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells [PDF]
, 2010 Doxorubicin is an anthracycline drug that is one of the most effective and widely used anticancer agents for the treatment of both hematologic and solid tumors.
Bruce E. Magun +6 more
core +2 more sources
Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells
bioRxiv, 2019 Cancerous inhibitor of protein phosphatase 2A (CIP2A) is involved in immune response, cancer progression, and in Alzheimer’s disease. However, an understanding of the mechanistic basis of its function in this wide spectrum of physiological and ...
Mohd Moin Khan +11 more
semanticscholar +1 more source
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease
Cell Reports, 2018 Summary: Protein phosphatase 2A (PP2A) inhibition causes hyperphosphorylation of tau and APP in Alzheimer’s disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear.
Yang-Ping Shentu +14 more
doaj +1 more source
Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. [PDF]
, 2017 Intratumoral heterogeneity (ITH) is a prominent feature of kidney cancer. It is not known whether it has utility in finding associations between protein expression and clinical parameters. We used ITH that is detected by immunohistochemistry (IHC) to aid
Devarajan, Karthik +10 more
core +3 more sources
α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]
, 2017 Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L +11 more
core +2 more sources
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Chronic Myeloid Leukaemia [PDF]
, 2016 Chronic myeloid leukaemia (CML) is a myeloproliferative disorder arising in a haematopoietic stem cell (HSC) and defined by the presence of BCR-ABL1, a deregulated tyrosine kinase that drives numerous oncogenic signalling pathways. Current CML therapies are tyrosine kinase inhibitors (TKIs) that target the constitutive action of BCR-ABL1.
openaire +1 more source
Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling [PDF]
, 2014 <b>Background:</b> Proteomics-based approaches for biomarker discovery are promising strategies used in cancer research. We present state-of-art label-free quantitative proteomics method to assess proteome of renal cell carcinoma (RCC ...
Atrih, A. +8 more
core +4 more sources
Pifu-xingbing zhenliaoxue zazhiObjective To investigate the expression levels of cancerous inhibitor of protein phosphatase 2A (CIP2A) and CD44v6 in condyloma acuminatum (CA)-involved skin and to analyze the correlation between their expression and the distribution of HPV genotypes in
ZHANG Yijie, YANG Can, LIN Yongli
doaj +1 more source
Cell Communication and Signaling, 2020 Background Increasing evidence has revealed a close correlation between cancerous inhibitor of protein phosphatase 2A (CIP2A) and cancer progression. CIP2A has been shown to participate in diverse biological processes, such as development, tumorigenic ...
Wei Chen +5 more
doaj +1 more source