Results 71 to 80 of about 299,477 (352)

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

Targeting Candida albicans filamentation for antifungal drug development

Virulence, 2017
Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised patients.
T. Vila, Jesús A. Romo, C. Pierce, Stanton F. McHardy, S. Saville, J. Lopez-Ribot   +5 more
semanticscholar   +1 more source

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

Advanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang, Xiao‐Mei Zhang, Xi Wu, Cheng‐Kai Zhou, Zhen‐Zhen Liu, Xue‐Yue Luo, Liang Zhang, Wei Chen, Yong‐Jun Yang   +8 more
wiley   +1 more source

Prevalence of oral parameters in smokeless tobacco-associated precancer

Journal of Family Medicine and Primary Care, 2019
Aim: To evaluate and correlate the prevalence of Candida species, salivary flow rate, pH, and buffer capacity of oral cavity in subjects with leukoplakia, tobacco pouch keratosis, and healthy controls.
Monika Negi, Namita Sepolia, Sheilesh Singh Panwar, Mamit Kumar, Jaya Singla, Rajeev Kumar Aggarwal   +5 more
doaj   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

Advanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia, Yan Liu, Yangkun Xing, Zhewei Shi, Xiaocheng Pang   +4 more
wiley   +1 more source

A CRISPR Cas9-based gene drive platform for genetic interaction analysis in Candida albicans

Nature Microbiology, 2017
Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR–Cas9-based ‘gene drive array’ platform to facilitate efficient genetic analysis
Rebecca S. Shapiro, Alejandro Chavez, C. Porter, Meagan Hamblin, C. Kaas, James E. DiCarlo, Guisheng Zeng, Xiaoli Xu, Alexey V. Revtovich, N. V. Kirienko, Yue Wang, G. Church, J. Collins   +12 more
semanticscholar   +1 more source

Genotype–Phenotype Correlations, Mortality, and Clinical Insights in Keratitis–Ichthyosis–Deafness Syndrome: A Comprehensive Review and Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Keratosis–ichthyosis–deafness (KID) syndrome is a rare autosomal dominant ectodermal disease caused by mutations in the GJB2 gene, which encodes the gap junction protein Connexin 26 (Cx26) located on Chr. 13q12.11. This study presents the first mortality analysis associated with KID syndrome, focusing on a case report of a Latin American ...
Leslie Patrón‐Romero, Marco Antonio Hernández Lepe, José de Jesús Manríquez Torres, Diego Daniel Aguirre‐Gómez, Natsuo Hayashi‐Mercado, Genaro Rodríguez Uribe, Tadeo Cerón, María Ruiz‐Gamboa, Jesús Alonso Gándara‐Mireles, Ismael Lares‐Asseff, Verónica Loera‐Castañeda, Jorge Alvelais‐Palacios, Lucrecia Arzamendi‐Cepeda, Lidia Magdalena Castañeda‐González, Adolfo García‐Barrón, Francisco Yamal Quiroz Herrera, Francisco González‐Salazar, Horacio Almanza‐Reyes   +17 more
wiley   +1 more source

The synthetic melanocortin (CKPV)2 exerts anti-fungal and anti-inflammatory effects against Candida albicans vaginitis via inducing macrophage M2 polarization. [PDF]

PLoS ONE, 2013
In this study, we examined anti-fungal and anti-inflammatory effects of the synthetic melanocortin peptide (Ac-Cys-Lys-Pro-Val-NH2)2 or (CKPV)2 against Candida albicans vaginitis.
Hai-xia Ji, Yu-lian Zou, Jing-jing Duan, Zhi-rong Jia, Xian-jing Li, Zhuo Wang, Li Li, Yong-wen Li, Gen-yan Liu, Ming-qing Tong, Xiao-yi Li, Guo-hui Zhang, Xiang-rong Dai, Ling He, Zhi-yu Li, Cong Cao, Yong Yang   +16 more
doaj   +1 more source

The Candida albicans Biofilm Matrix: Composition, Structure and Function

Journal of Fungi, 2017
A majority of infections caused by Candida albicans—the most frequent fungal pathogen—are associated with biofilm formation. A salient feature of C. albicans biofilms is the presence of the biofilm matrix.
C. Pierce, T. Vila, Jesús A. Romo, Daniel Montelongo-Jauregui, G. Wall, Anand K. Ramasubramanian, J. Lopez-Ribot   +6 more
semanticscholar   +1 more source

Leucine Aminopeptidase in Candida Albicans

Journal of Investigative Dermatology, 1962
Since the late 19th century, there have been numerous publications on proteolytic enzymes in dermatophytes (for literature see 1-5). Bodin (1907), Mallinckrodt-Haupt (1928), and Tate (1929) stated that active proteolytic enzymes (e.g. trypsin, casease, renin, gelatinase (1, 2), or enzymes with activity very similar to trypsin (3)) are present in the ...
Donald Chow, Young Pio Kim, Kenji A. Adachi   +2 more
openaire   +3 more sources