Results 131 to 140 of about 3,878,610 (315)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Candidate gene analysis of two SNPs in the candidate gene CDH2.

, 2012
Candidate gene analysis of two SNPs in the candidate gene CDH2.
Osmo Hakosalo (147866), Katriina Tiira (147857), Paul Arnold (147900), Lauri Kareinen (147874), Anne Thomas (90885), Catherine Escriou (147892), Hannes Lohi (102236), Anna Hielm-Björkman (147885)   +7 more
core   +1 more source

Candidate Gene Identification Approach: Progress and Challenges

International Journal of Biological Sciences, 2007
Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene approach is largely limited by its reliance on the ...
Mengjin Zhu, Shuhong Zhao
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Candidate gene mapping: approach, methods and significance [PDF]

, 2013
Candidate gene is a gene with known or assumed function that may affect genetic control of a trait and thus, can be considered a 'candidate gene' for this trait. The Candidate gene associates a gene to its phenotypic trait.
Nirali K Patel, Shivani Patel
core  

Candidate gene selection strategies.

, 2015
Candidate gene selection strategies.
James C. Lee (277043), Michael E. Weale (267983), Sarah L. Spain (447823), Kirstin Taylor (691598), Bu’Hussain Hayee (691604), Suzannah J. Bumpstead (262577), Peter Green (691602), Franca Fraternali (59336), Kristina Stone (691597), Ariella Amar (691600), Cathryn M. Lewis (126002), Grace Lu (691599), Richard Pollok (691605), Hannah Bye (691601), Christopher G. Mathew (77523), Jeremy Sanderson (652025), Jo Knight (352637), Efterpi Papouli (553691), Jack Satsangi (259264), Jeffrey C. Barrett (210184), Muddassar M. Mirza (688034), Natalie J. Prescott (77518), Emma Gray (415111), Miles Parkes (268933), Benjamin Lehne (215790), Michael A. Simpson (447824), Thomas Schlitt (35024), Guy Chung-Faye (691603), John C. Mansfield (691606)   +28 more
core   +1 more source

GWAS combined with linkage analysis reveals major QTLs and candidate genes of salt tolerance in Japonica rice seedlings

Frontiers in Plant Science
BackgroundSoil salinization is one of the significant factors limiting high crop yields and expansion of arable land, seriously affecting global agricultural production.
Shanbin Xu, Jie Zheng, Haoqiang Du, Xiaodong Du, Chong Li, Yuxuan Duan, Yanan Cai, Jingguo Wang, Hualong Liu, Luomiao Yang, Wei Xin, Yan Jia, Detang Zou, Hongliang Zheng   +13 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Identification of QTL for branch traits in soybean (Glycine max L.) and its application in genomic selection

Frontiers in Genetics
IntroductionBranches are important for soybean yield, and previous studies examining branch traits have primarily focused on branch number (BN), while research assessing branch internode number (BIN), branch length (BL), and branch internode length (BIL)
Qichao Yang, Jing Wang, Jing Wang, Yajun Xiong, Yajun Xiong, Alu Mao, Alu Mao, Zhiqing Zhang, Zhiqing Zhang, Yijie Chen, Yijie Chen, Shirui Teng, Shirui Teng, Zhiyu Liu, Jun Wang, Jun Wang, Jian Song, Lijuan Qiu, Lijuan Qiu, Lijuan Qiu, Lijuan Qiu   +20 more
doaj   +1 more source