Results 201 to 210 of about 662,534 (268)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

open access: yesAdvanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao   +16 more
wiley   +1 more source

STARD9 and CDK5RAP2-Novel Candidate Genes for 46,XY Complete Gonadal Dysgenesis. [PDF]

open access: yesInt J Mol Sci
Sirokha D   +12 more
europepmc   +1 more source

Integrating QTL mapping with transcriptome analysis uncovers candidate genes of ear length in maize. [PDF]

open access: yesBMC Plant Biol
Hou B   +14 more
europepmc   +1 more source

Candidate genes related to growth and milk production in three Anatolian goats revealed by GWAS. [PDF]

open access: yesMamm Genome
Demir E   +8 more
europepmc   +1 more source

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