Results 1 to 10 of about 135,319 (315)

Identification of CTSK as a TLR-related critical biomarker in liver cirrhosis via integrative bioinformatics and pathological characterization

Scientific Reports
Liver cirrhosis (LC) is a common chronic disease worldwide with a poor prognosis, and its pathogenesis has not been fully elucidated. Toll-like receptors (TLRs) are crucial in LC progression.
Jiaxin Wang, Ning Li, Xueyu Cang, Xuerong Liu, Ranyan Gao, Lingyi Xu, Fengchun Li, Xinyu Jiang, Hongliang Chen, Xinyu Geng, Jihan Qi, Ram Prasad Chaulagain, Junchong He, Shizhu Jin   +13 more
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Transcriptomic analysis reveals cross-talk genes between type 2 diabetes and recurrent benign paroxysmal positional vertigo

Heliyon
Background: Benign paroxysmal positional vertigo (BPPV) is a common neurological disorder with a high recurrence rate. Type 2 diabetes mellitus (T2DM) is recognized as a risk factor for BPPV recurrence.
Jing Hui, Dingjing Zi, LePing Liang, Xiaoyong Ren   +3 more
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Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration

Frontiers in Physiology
BackgroundIntestinal ischemia-reperfusion (II/R) injury is a serious condition characterized by high morbidity and mortality rates. Research has shown that II/R injury is closely linked to autophagy and immune dysregulation.
Yichen Hu, Qinghua Zou, Yanbo Sun, Weiming Li, Zhaochuan Yin, Yuanpei Zhao, Kaiwen Shi, Hongyuan Liu, Jiahui Wang   +8 more
doaj   +1 more source

Adrenocortical carcinoma survival gene HMMR was identified as being targeted by fluorouracil and epirubicin using a gene coexpression network-based drug repositioning strategy

Scientific Reports
Adrenocortical carcinoma (ACC), with poor prognosis, is one of the most aggressive endocrine cancers. Surgery is the mainstay of treatment; nevertheless, chemotherapy is usually needed.
Zahra Jafari, Seyed-Morteza Javadirad, Seyede Elmira Yazdi Rouholamini   +2 more
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Screening Hub Genes as Prognostic Biomarkers of Hepatocellular Carcinoma by Bioinformatics Analysis

Cell Transplantation, 2019
Hepatocellular carcinoma (HCC) is a widespread, common type of cancer in Asian countries, and the need for biomarker-matched molecularly targeted therapy for HCC has been increasingly recognized.
Zengyuan Zhou, Yuzheng Li, Haiyue Hao, Yuanyuan Wang, Zihao Zhou, Zhipeng Wang, Xia Chu   +6 more
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Identification of novel hub genes and immune infiltration in atopic dermatitis using integrated bioinformatics analysis

Scientific Reports
The aim of this study was to identify key genes and investigate the immunological mechanisms of atopic dermatitis (AD) at the molecular level via bioinformatics analysis.
Yaguang Zhou, Yong Zhou, Suli Zhang, Shui Yu, Zizhuo Li, Zhou Yang, You Wu, Zigang Zhao, Han Zhang, Chengxin Li   +9 more
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Gradient boosting-based classification of interactome hub genes in periimplantitis with periodontitis – an integrated bioinformatic approach

Frontiers in Oral Health
IntroductionPeri-implantitis, a destructive inflammatory condition affecting the tissues surrounding dental implants, shares pathological similarities with periodontitis, a chronic inflammatory disease that impacts the supporting structures of natural ...
Pradeep Kumar Yadalam, Sarvagya Sharma, Prabhu Manickam Natarajan, Carlos M. Ardila   +3 more
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Gene screening and immune phenotype shifts of osteoporosis

Scientific Reports
Osteoporosis (OP) is a prevalent chronic systemic metabolic bone disease, with its pathogenesis remaining largely unclear. This study employs machine learning and bioinformatics analyses to identify the hub genes associated with OP and to investigate the
Xinxin Hu, Limin Tian
doaj   +1 more source

Identification of unique biomarkers in colorectal cancer based on comprehensive analysis and machine learning

Frontiers in Oncology
IntroductionColorectal cancer (CRC) is a common malignant tumor with high incidence and poor prognosis. Identifying effective biomarkers is crucial for its diagnosis and treatment.MethodsGene expression data were obtained from TCGA-CRC and GSE39582 ...
Liwei Wang, Aigang Ren, Xiaolong Cui, Yuan Shen, Qingxing Huang   +4 more
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Identification and validation of voltage‐dependent anion channel 1‐related genes and immune cell infiltration in diabetic nephropathy

Journal of Diabetes Investigation
Aims/Introduction This study investigated the roles of voltage‐dependent anion channel 1‐related differentially expressed genes (VRDEGs) in diabetic nephropathy (DN).
Jiaqun Lin, Mengjie Weng, Jing Zheng, Kun Nie, Siyi Rao, Yongjie Zhuo, Jianxin Wan   +6 more
doaj   +1 more source