Results 1 to 10 of about 8,236,393 (357)

Identification of hub genes predicting the development of prostate cancer from benign prostate hyperplasia and analyzing their clinical value in prostate cancer by bioinformatic analysis

Discover Oncology, 2022
Prostate cancer (PCa) and benign prostate hyperplasia (BPH) are commonly encountered diseases in males. Studies showed that genetic factors are responsible for the occurrences of both diseases.
Xi Chen, Junjie Ma, Chengdang Xu, Licheng Wang, Yicong Yao, Xinan Wang, Tong Zi, Cuidong Bian, Denglong Wu, Gang Wu   +9 more
doaj   +3 more sources

Functional investigation and two-sample Mendelian randomization study of neuropathic pain hub genes obtained by WGCNA analysis

Frontiers in Neuroscience, 2023
Objective Neuropathic pain as a complex chronic disease that occurs after neurological injury, however the underlying mechanisms are not clarified in detail, hence therapeutic options are limited.
Jianwei Luo, Jianfeng Zeng, Cong Lai
exaly   +2 more sources

Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis

Frontiers in Pharmacology, 2022
Objectives: Lung cancer is one of the most common cancers worldwide and it is the leading cause of cancer-related mortality. Despite the treatment of patients with non-small cell lung carcinoma (NSCLC) have improved, the molecular mechanisms of NSCLC are
Xie Mengyan, Ding Kun, Ding Kun, Ding Kun, Jing Xinming, Wei Yutian, Shu Yongqian, Shu Yongqian   +7 more
doaj   +2 more sources

Identification of Hub Genes and Construction of a Transcriptional Regulatory Network Associated With Tumor Recurrence in Colorectal Cancer by Weighted Gene Co-expression Network Analysis

Frontiers in Genetics, 2021
Tumor recurrence is one of the most important risk factors that can negatively affect the survival rate of colorectal cancer (CRC) patients. However, the key regulators dictating this process and their exact mechanisms are understudied.
Shengwei Liu, Shengwei Liu, Fanping Zeng, Guangwen Fan, Qiyong Dong   +4 more
doaj   +3 more sources

Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification [PDF]

International Journal of Ophthalmology, 2023
AIM: To explore hub genes for glaucoma based on bioinformatics analysis and an experimental model verification. METHODS: In the Gene Expression Omnibus (GEO) database, the GSE25812 and GSE26299 datasets were selected to analyze differentially expressed ...
Rui-Ling Xie, Hai-Yan Nie, Yu-Xin Xu
doaj   +1 more source

Identification of Biomarkers Associated With CD8+ T Cells in Coronary Artery Disease and Their Pan-Cancer Analysis

Frontiers in Immunology, 2022
PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao, Yinteng Wu, Yantao Wei, Xiaoyu Xu, Jialin Zheng   +4 more
doaj   +1 more source

Identification of hub genes and potential molecular mechanisms related to radiotherapy sensitivity in rectal cancer based on multiple datasets

Journal of Translational Medicine, 2023
Background Radiotherapy resistance is the main cause of low tumor regression for locally advanced rectum adenocarcinoma (READ). The biomarkers correlated to radiotherapy sensitivity and potential molecular mechanisms have not been completely elucidated ...
Pengfei Zhao, Hong-Chao Zhen, Hong Zhao, Yong-Fa Huang, B. Cao   +4 more
semanticscholar   +1 more source

Novel diagnostic and prognostic biomarkers of colorectal cancer: Capable to overcome the heterogeneity-specific barrier and valid for global applications.

PLoS ONE, 2021
IntroductionThe heterogeneity-specific nature of the available colorectal cancer (CRC) biomarkers is significantly contributing to the cancer-associated high mortality rate worldwide.
Yasir Hameed, Muhammad Usman, Shufang Liang, Samina Ejaz   +3 more
doaj   +1 more source

Identification and validation of oxidative stress and immune-related hub genes in Alzheimer’s disease through bioinformatics analysis

Scientific Reports, 2023
Alzheimer’s disease (AD) is the leading cause of dementia in aged population. Oxidative stress and neuroinflammation play important roles in the pathogenesis of AD.
Sheng-Jie Li, Jinting Xiao, Chuan-Jiang Huang, Ji-Kui Sun   +3 more
semanticscholar   +1 more source

Differentially expressed discriminative genes and significant meta-hub genes based key genes identification for hepatocellular carcinoma using statistical machine learning

Scientific Reports, 2023
Hepatocellular carcinoma (HCC) is the most common lethal malignancy of the liver worldwide. Thus, it is important to dig the key genes for uncovering the molecular mechanisms and to improve diagnostic and therapeutic options for HCC.
Md. Al Mehedi Hasan, Md. Maniruzzaman, Jung-pil Shin   +2 more
semanticscholar   +1 more source