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Identification and Validation of Hub Genes in Hidradenitis Suppurativa. [PDF]
Clin Cosmet Investig DermatolHidradenitis suppurativa (HS) is a severe, chronic inflammatory disease characterized by inflammatory nodules, progressive sinus tracts, and fistulas. Currently, its pathogenesis remain incompletely understood, and while diverse treatments are available, these have suboptimal efficacy.
Zhai YN +8 more
europepmc +4 more sources
Screening Hub Genes as Prognostic Biomarkers of Hepatocellular Carcinoma by Bioinformatics Analysis
Cell Transplantation, 2019 Hepatocellular carcinoma (HCC) is a widespread, common type of cancer in Asian countries, and the need for biomarker-matched molecularly targeted therapy for HCC has been increasingly recognized.
Zengyuan Zhou +6 more
doaj +2 more sources
Identification of the Hub Genes in Alzheimer’s Disease [PDF]
Computational and Mathematical Methods in Medicine, 2021 Purpose. Alzheimer’s disease (AD) is considered to be the most common neurodegenerative disease and also one of the major fatal diseases affecting the elderly, thus bringing a huge burden to society. Therefore, identifying AD-related hub genes is extremely important for developing novel strategies against AD. Materials and Methods.
Huiwen Gui +4 more
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Identification and validation of hub differential genes in pulmonary sarcoidosis
Frontiers in ImmunologyA total of 138 cDEGs were screened from mediastinal lymph nodes and peripheral whole blood. Among them, 6 hub cDEGs including CTSS, CYBB, FPR2, MNDA, TLR1 and TLR8 with elevated degree and betweenness levels were illustrated in protein-protein interaction network. In comparison to healthy controls, CTSS (1.61 vs. 1.05), CYBB (1.68 vs. 1.07), FPR2 (2.77
Dong Weng
exaly +4 more sources
Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification [PDF]
International Journal of Ophthalmology, 2023 AIM: To explore hub genes for glaucoma based on bioinformatics analysis and an experimental model verification. METHODS: In the Gene Expression Omnibus (GEO) database, the GSE25812 and GSE26299 datasets were selected to analyze differentially expressed ...
Rui-Ling Xie, Hai-Yan Nie, Yu-Xin Xu
doaj +1 more source
Frontiers in Immunology, 2022 PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao +4 more
doaj +1 more source
Prediction and analysis of osteoarthritis hub genes with bioinformatics
Annals of Translational Medicine, 2023 Osteoarthritis (OA) is the most common type of arthritis. OA can cause joint pain, stiffness, and loss of function. The pathogenesis of OA is not completely clear. Moreover, there is no effective treatment, and clinical management is limited to symptomatic relief or joint surgery.
Zhong, Junqing, Xiang, Ding, Ma, Xinlong
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Frontiers in Pharmacology, 2022 Objectives: Lung cancer is one of the most common cancers worldwide and it is the leading cause of cancer-related mortality. Despite the treatment of patients with non-small cell lung carcinoma (NSCLC) have improved, the molecular mechanisms of NSCLC are
Xie Mengyan +7 more
doaj +1 more source
Identification and validation of hub genes for diabetic retinopathy
PeerJ, 2021 Background Diabetic retinopathy (DR) is characterized by a gradually progressive alteration in the retinal microvasculature that leads to middle-aged adult acquired persistent blindness. Limited research has been conducted on DR pathogenesis at the gene level.
Peng, Li +3 more
openaire +3 more sources
Hub Genes Associated with the Diagnosis of Diabetic Retinopathy
International Journal of General Medicine, 2021 This study aimed to identify genes that may be effective in diagnosing or treating diabetic retinopathy (DR), the most common complication of diabetes mellitus (DM).Differentially expressed genes (DEGs) were identified between DR and DM in GSE146615 dataset.
Yanhui Tang +6 more
openaire +5 more sources