Results 11 to 20 of about 135,319 (315)

Identification of Hub Genes and Construction of a Transcriptional Regulatory Network Associated With Tumor Recurrence in Colorectal Cancer by Weighted Gene Co-expression Network Analysis

Frontiers in Genetics, 2021
Tumor recurrence is one of the most important risk factors that can negatively affect the survival rate of colorectal cancer (CRC) patients. However, the key regulators dictating this process and their exact mechanisms are understudied.
Shengwei Liu, Shengwei Liu, Fanping Zeng, Guangwen Fan, Qiyong Dong   +4 more
doaj   +3 more sources

Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis

Frontiers in Pharmacology, 2022
Objectives: Lung cancer is one of the most common cancers worldwide and it is the leading cause of cancer-related mortality. Despite the treatment of patients with non-small cell lung carcinoma (NSCLC) have improved, the molecular mechanisms of NSCLC are
Xie Mengyan, Ding Kun, Ding Kun, Ding Kun, Jing Xinming, Wei Yutian, Shu Yongqian, Shu Yongqian   +7 more
doaj   +3 more sources

Identification of the Hub Genes in Alzheimer’s Disease [PDF]

Computational and Mathematical Methods in Medicine, 2021
Purpose. Alzheimer’s disease (AD) is considered to be the most common neurodegenerative disease and also one of the major fatal diseases affecting the elderly, thus bringing a huge burden to society. Therefore, identifying AD-related hub genes is extremely important for developing novel strategies against AD. Materials and Methods.
Huiwen Gui, Qi Gong, Jun Jiang, Mei Liu, Huanyin Li   +4 more
openaire   +2 more sources

Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification [PDF]

International Journal of Ophthalmology, 2023
AIM: To explore hub genes for glaucoma based on bioinformatics analysis and an experimental model verification. METHODS: In the Gene Expression Omnibus (GEO) database, the GSE25812 and GSE26299 datasets were selected to analyze differentially expressed ...
Rui-Ling Xie, Hai-Yan Nie, Yu-Xin Xu
doaj   +1 more source

Meta-Data Analysis to Explore the Hub of the Hub-Genes That Influence SARS-CoV-2 Infections Highlighting Their Pathogenetic Processes and Drugs Repurposing [PDF]

, 2022
The pandemic of SARS-CoV-2 infections is a severe threat to human life and the world economic condition. Although vaccination has reduced the outspread, but still the situation is not under control because of the instability of RNA sequence patterns of ...
Gow, Jeff, Khorshed Alam, Alam, Khorshed, Md. Bayazid Hossen, Gow, Jeffrey, Md. Kaderi Kibria, Md. Selim Reza, Reza, Md. Selim, Jeff Gow, Mahumud, Rashidul Alam, Kibria, Md. Kaderi, Md. Parvez Mosharaf, Rashidul Alam Mahumud, Md. Nurul Haque Mollah, Md. Ariful Islam, Mosharaf, Md. Parvez, Hossen, Md. Bayazid, Islam, Md. Ariful, Mollah, Md. Nurul Haque   +18 more
core   +1 more source

Identification of Biomarkers Associated With CD8+ T Cells in Coronary Artery Disease and Their Pan-Cancer Analysis

Frontiers in Immunology, 2022
PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao, Yinteng Wu, Yantao Wei, Xiaoyu Xu, Jialin Zheng   +4 more
doaj   +1 more source

Prediction and analysis of osteoarthritis hub genes with bioinformatics

Annals of Translational Medicine, 2023
Osteoarthritis (OA) is the most common type of arthritis. OA can cause joint pain, stiffness, and loss of function. The pathogenesis of OA is not completely clear. Moreover, there is no effective treatment, and clinical management is limited to symptomatic relief or joint surgery.
Zhong, Junqing, Xiang, Ding, Ma, Xinlong
openaire   +2 more sources

Identification and validation of hub genes for diabetic retinopathy

PeerJ, 2021
Background Diabetic retinopathy (DR) is characterized by a gradually progressive alteration in the retinal microvasculature that leads to middle-aged adult acquired persistent blindness. Limited research has been conducted on DR pathogenesis at the gene level.
Peng, Li, Ma, Wei, Xie, Qing, Chen, Baihua   +3 more
openaire   +3 more sources

Hub Genes Associated with the Diagnosis of Diabetic Retinopathy

International Journal of General Medicine, 2021
This study aimed to identify genes that may be effective in diagnosing or treating diabetic retinopathy (DR), the most common complication of diabetes mellitus (DM).Differentially expressed genes (DEGs) were identified between DR and DM in GSE146615 dataset.
Yanhui Tang, Qi Tang, Haicheng Wei, Pinzhang Hu, Donghua Zou, Rixiong Liang, Yu Ling   +6 more
openaire   +5 more sources

Novel diagnostic and prognostic biomarkers of colorectal cancer: Capable to overcome the heterogeneity-specific barrier and valid for global applications.

PLoS ONE, 2021
IntroductionThe heterogeneity-specific nature of the available colorectal cancer (CRC) biomarkers is significantly contributing to the cancer-associated high mortality rate worldwide.
Yasir Hameed, Muhammad Usman, Shufang Liang, Samina Ejaz   +3 more
doaj   +1 more source