Results 1 to 10 of about 125,842 (119)

Machine Learning Model for Lymph Node Metastasis Prediction in Breast Cancer Using Random Forest Algorithm and Mitochondrial Metabolism Hub Genes

Applied Sciences, 2021
Breast cancer metastasis can have a fatal outcome, with the prediction of metastasis being critical for establishing effective treatment strategies.
Byung-Chul Kim, Jingyu Kim, Ilhan Lim, Dong Ho Kim, Sang Moo Lim, Sang-Keun Woo   +5 more
doaj   +1 more source

Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis

Frontiers in Immunology, 2022
BackgroundCalcific aortic valve disease (CAVD) is a progressive fibrocalcific disease that can be treated only through valve replacement. This study aimed to determine the role of hub genes and immune cell infiltration in CAVD progression.MethodsIn this ...
Kan Wang, Qiang Zheng, Xing Liu, BingChuan Geng, NianGuo Dong, JiaWei Shi   +5 more
doaj   +1 more source

Statistical Approaches for Gene Selection, Hub Gene Identification and Module Interaction in Gene Co-Expression Network Analysis: An Application to Aluminum Stress in Soybean (Glycine max L.). [PDF]

PLoS ONE, 2017
Selection of informative genes is an important problem in gene expression studies. The small sample size and the large number of genes in gene expression data make the selection process complex.
Samarendra Das, Prabina Kumar Meher, Anil Rai, Lal Mohan Bhar, Baidya Nath Mandal   +4 more
doaj   +1 more source

Identification of Molecular Signatures and Candidate Drugs in Vascular Dementia by Bioinformatics Analyses

Frontiers in Molecular Neuroscience, 2022
Vascular dementia (VaD) is considered to be the second most common form of dementia after Alzheimer’s disease, and no specific drugs have been approved for VaD treatment.
Jun Shu, Wenshi Wei, Li Zhang
doaj   +1 more source

Identification of hub genes and construction of diagnostic nomogram model in schizophrenia

Frontiers in Aging Neuroscience, 2022
Schizophrenia (SCZ), which is characterized by debilitating neuropsychiatric disorders with significant cognitive impairment, remains an etiological and therapeutic challenge.
Chi Zhang, Naifu Dong, Shihan Xu, Haichun Ma, Min Cheng   +4 more
doaj   +1 more source

Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis

Scientific Reports, 2022
Type 1 diabetes mellitus (T1DM) is a metabolic disorder for which the underlying molecular mechanisms remain largely unclear. This investigation aimed to elucidate essential candidate genes and pathways in T1DM by integrated bioinformatics analysis.
Madhu Pujar, Basavaraj Vastrad, Satish Kavatagimath, Chanabasayya Vastrad, Shivakumar Kotturshetti   +4 more
doaj   +1 more source

Identification of hub genes in papillary thyroid carcinoma: robust rank aggregation and weighted gene co-expression network analysis

Journal of Translational Medicine, 2020
Background Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic for PTC are incomplete.
Yang Liu, Ting-Yu Chen, Zhi-Yan Yang, Wei Fang, Qian Wu, Chao Zhang   +5 more
doaj   +1 more source

Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration

Frontiers in Genetics, 2021
Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang, Hantao Wang, Wenhui Liu, Bo Yu, Xiaosheng Yu, Bin Chen   +5 more
doaj   +1 more source

Identification of Biomarkers Associated With CD8+ T Cells in Coronary Artery Disease and Their Pan-Cancer Analysis

Frontiers in Immunology, 2022
PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao, Yinteng Wu, Yantao Wei, Xiaoyu Xu, Jialin Zheng   +4 more
doaj   +1 more source

Candidate Genes Identified in Systemic Sclerosis-Related Pulmonary Arterial Hypertension Were Associated with Immunity, Inflammation, and Cytokines

Cardiovascular Therapeutics, 2021
Background. Pulmonary complications of systemic sclerosis (SSc), including pulmonary arterial hypertension (PAH), are the leading causes of patient death. However, the precise molecular mechanisms of its etiology are unclear.
Zhixiao Xu, Jiaxing Ruan, Lingyun Pan, Chengshui Chen   +3 more
doaj   +1 more source