Results 41 to 50 of about 125,991 (267)
Hub genes and their key effects on prognosis of Burkitt lymphoma
World Journal of Clinical Oncology, 2023 Burkitt lymphoma (BL) is an exceptionally aggressive malignant neoplasm that arises from either the germinal center or post-germinal center B cells. Patients with BL often present with rapid tumor growth and require high-intensity multi-drug therapy combined with adequate intrathecal chemotherapy prophylaxis, however, a standard treatment program for ...
Xu, Yan-Feng +3 more
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Frontiers in Genetics, 2021 Despite the recent progress of lung adenocarcinoma (LUAD) therapy, tumor recurrence remained to be a challenging factor that impedes the effectiveness of treatment. The objective of the present study was to predict the hub genes affecting LUAD recurrence
Zhengze Shen +4 more
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Hub gene associated with prognosis in bladder cancer is a novel therapeutic target [PDF]
PeerJ, 2023 Objective Bladder cancer is a clinical and social conundrum due to its high incidence and recurrence rate. It is urgent to find new targets for the diagnosis and treatment of bladder cancer and improve the prognosis and survival rate of bladder cancer ...
Dengpan Fang +4 more
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Evidence of Highly Regulated Genes (in-Hubs) in Gene Networks of Saccharomyces Cerevisiae [PDF]
Bioinformatics and Biology Insights, 2008 Uncovering interactions between genes, gene networks, is important to increase our understanding of intrinsic cellular processes and responses to external stimuli such as drugs. Gene networks can be computationally inferred from repeated measurements of gene expression, using algorithms, which assume that each gene is controlled by only a small number ...
Jesper Lundström +2 more
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Hub Gene Selection Methods for the Reconstruction of Transcription Networks [PDF]
, 2010 Abstract Transcription control networks have a scale-free topological structure: While most genes are involved in a reduced number of links, a few hubs or key regulators are connected to a significantly large number of nodes. Several methods have been developed for the reconstruction of these networks from gene expression data, e.g. ARACNE.
Hernandez-Lobato, J., Dijkstra, T.M.H.
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Identification of the hub genes RUNX2 and FN1 in gastric cancer [PDF]
Open Medicine, 2020 Abstract Background This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes. Methods
Han Chao +5 more
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Scientific Reports, 2023 Alzheimer’s disease (AD) is the most prevalent dementia disorder globally, and there are still no effective interventions for slowing or stopping the underlying pathogenic mechanisms.
Yanting Zhang, Hisanori Kiryu
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Network Analyses of Differentially Expressed Genes in Osteoarthritis to Identify Hub Genes [PDF]
BioMed Research International, 2019 Background. Osteoarthritis (OA) is the most common degenerative disease in orthopedics. However, the cause and underlying molecular mechanisms are not clear. This study aims to identify the hub genes and pathways involved in the occurrence of osteoarthritis. Methods.
Zhaoyan Li +8 more
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Italian Journal of MedicineSchizophrenia is thought to be the most prevalent chronic psychiatric disorder. Researchers have identified numerous proteins associated with the occurrence and development of schizophrenia. This study aimed to identify potential core genes and pathways
Iranna Kotturshetti +4 more
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BMC Medical Genomics, 2022 Objective This study identified underlying genetic molecules associated with histologically unstable carotid atherosclerotic plaques through bioinformatics analysis that may be potential biomarkers and therapeutic targets.
Julong Guo +4 more
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