Results 31 to 40 of about 124,378 (265)
The Core Promoter Is a Regulatory Hub for Developmental Gene Expression [PDF]
Frontiers in Cell and Developmental Biology, 2021 The development of multicellular organisms and the uniqueness of each cell are achieved by distinct transcriptional programs. Multiple processes that regulate gene expression converge at the core promoter region, an 80 bp region that directs accurate transcription initiation by RNA polymerase II (Pol II).
Anna Sloutskin +3 more
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Frontiers in Genetics, 2021 ObjectiveThe aim of this study is the identification of hub genes associated with idiopathic pulmonary arterial hypertension (IPAH).Materials and MethodsGSE15197 gene expression data was downloaded from the Gene Expression Omnibus (GEO) database ...
Xue Qiu +5 more
doaj +1 more source
Journal of Immunology Research, 2023 Background. Kawasaki disease (KD) is characterized by a disordered inflammation response of unknown etiology. Immune cells are closely associated with its onset, although the immune-related genes’ expression and possibly involved immune regulatory ...
Hongjun Ba +10 more
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Frontiers in Genetics, 2023 Background: Fibrotic skin diseases are characterized by excessive accumulation of the extracellular matrix (ECM) and activation of fibroblasts, leading to a global healthcare burden. However, effective treatments of fibrotic skin diseases remain limited,
Ting Wu +9 more
doaj +1 more source
ComHub: Community predictions of hubs in gene regulatory networks [PDF]
BMC Bioinformatics, 2019 Abstract Summary Hub transcription factors, regulating many target genes in gene regulatory networks (GRNs), play important roles as disease regulators and potential drug targets. However, while numerous methods have been developed to predict individual regulator-gene interactions from gene ...
Åkesson, Julia +3 more
openaire +6 more sources
Frontiers in Physiology, 2017 Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li +14 more
doaj +1 more source
Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
openaire +2 more sources
LongGeneDB: a data hub for long genes [PDF]
, 2020 ABSTRACT The human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases.
Sohyun Moon +3 more
openaire +1 more source
Identification of the potential novel biomarkers as susceptibility gene for Wilms tumor
BMC Cancer, 2021 Background Wilms tumor (WT) is the most common malignant renal tumor in children. The aim of this study was to identify potential susceptibility gene of WT for better prognosis.
Li Liu +6 more
doaj +1 more source
Identification of potential biomarkers of vascular calcification using bioinformatics analysis and validation in vivo [PDF]
PeerJ, 2022 Background Vascular calcification (VC) is the most widespread pathological change in diseases of the vascular system. However, we know poorly about the molecular mechanisms and effective therapeutic approaches of VC.
Chuanzhen Chen +4 more
doaj +2 more sources