Results 31 to 40 of about 125,991 (267)
Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis
Frontiers in Genetics, 2022 The present study was performed to explore the underlying molecular mechanisms and screen hub genes of osteoarthritis (OA) via bioinformatics analysis. In total, twenty-five OA synovial tissue samples and 25 normal synovial tissue samples were derived from three datasets, namely, GSE55457, GSE55235, and GSE1919, and were used to identify the ...
Jian Zhou +9 more
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LongGeneDB: a data hub for long genes [PDF]
, 2020 ABSTRACT The human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases.
Sohyun Moon +3 more
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Journal of Immunology Research, 2023 Background. Kawasaki disease (KD) is characterized by a disordered inflammation response of unknown etiology. Immune cells are closely associated with its onset, although the immune-related genes’ expression and possibly involved immune regulatory ...
Hongjun Ba +10 more
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Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
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Rutin Effects on Human Senescent Stromal Cells Function: a Network Analysis Study [PDF]
Research Journal of PharmacognosyBackground and objectives: Rutin is a lipophilic natural flavonoid. It is found in vegetables, citrus fruits, and beverages. This study aims to evaluate rutin metabolic pathways in human senescent stromal cells.
Reza Robati +7 more
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Integrative analysis of ferroptosis-related genes in ulcerative colitis
Journal of International Medical Research, 2021 Objective The aim of this study was to identify and validate ferroptosis-related markers in ulcerative colitis (UC) to explore new directions for UC diagnosis and treatment.
De-jun Cui +4 more
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Identification of potential biomarkers of vascular calcification using bioinformatics analysis and validation in vivo [PDF]
PeerJ, 2022 Background Vascular calcification (VC) is the most widespread pathological change in diseases of the vascular system. However, we know poorly about the molecular mechanisms and effective therapeutic approaches of VC.
Chuanzhen Chen +4 more
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Exploration of the hub genes and miRNAs in lung adenocarcinoma
Oncology Letters, 2019 In order to investigate the oncogenic mechanisms of lung adenocarcinoma (LUAD), hub genes can be identified by constructing co-expression networks, and the potential linkages between hub genes, transcription factors (TFs) and microRNAs (miRNAs/miRs) can be visualized and identified.
Zhai, Yuanyuan +3 more
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, 2023 Abstract Background The aim of this study was to identify hub genes, related transcription factors (TFs) and miRNAs from the miRNA–TF–gene interaction network in necrotizing enterocolitis (NEC). Methods Three expression data sets from GEO database that compared NEC with surgical negative controls were used to calculate differentially ...
Yuqian Su +6 more
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Enhanced construction of gene regulatory networks using hub gene information [PDF]
BMC Bioinformatics, 2017 Gene regulatory networks reveal how genes work together to carry out their biological functions. Reconstructions of gene networks from gene expression data greatly facilitate our understanding of underlying biological mechanisms and provide new opportunities for biomarker and drug discoveries.
Donghyeon Yu +4 more
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