Results 31 to 40 of about 10,923,960 (347)

Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration

Frontiers in Genetics, 2021
Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang, Hantao Wang, Wenhui Liu, Bo Yu, Xiaosheng Yu, Bin Chen   +5 more
doaj   +1 more source

Identification of hub genes in papillary thyroid carcinoma: robust rank aggregation and weighted gene co-expression network analysis

Journal of Translational Medicine, 2020
Background Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic for PTC are incomplete.
Yang Liu, Ting-Yu Chen, Zhi-Yan Yang, Wei Fang, Qian Wu, Chao Zhang   +5 more
doaj   +1 more source

Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis

Scientific Reports, 2022
Type 1 diabetes mellitus (T1DM) is a metabolic disorder for which the underlying molecular mechanisms remain largely unclear. This investigation aimed to elucidate essential candidate genes and pathways in T1DM by integrated bioinformatics analysis.
Madhu Pujar, Basavaraj Vastrad, Satish Kavatagimath, Chanabasayya Vastrad, Shivakumar Kotturshetti   +4 more
doaj   +1 more source

The Comprehensive Analysis of Hub Gene ARRB2 in Prostate Cancer

Disease Markers, 2022
Methods The differential expressed genes (DEGs) were screened from the gene expression profile GSE30994 related to PRAD and then analyzed by protein-protein interaction (PPI) to screen the hub gene.
Bing-Xia Zhou, Hong Song, Wu-Qin Xu, Yanbin Zhang, Yin-Hua Liu, Wei Qi   +5 more
semanticscholar   +1 more source

Identification of Biomarkers Associated With CD8+ T Cells in Coronary Artery Disease and Their Pan-Cancer Analysis

Frontiers in Immunology, 2022
PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao, Yinteng Wu, Yantao Wei, Xiaoyu Xu, Jialin Zheng   +4 more
doaj   +1 more source

Identification of UBE2C as hub gene in driving prostate cancer by integrated bioinformatics analysis

PLoS ONE, 2021
Background The aim of this study was to identify novel genes in promoting primary prostate cancer (PCa) progression and to explore its role in the prognosis of prostate cancer.
Yan Wang, Ji-li Wang, Qiu-Su Tang, G. Ren   +3 more
semanticscholar   +1 more source

Candidate Genes Identified in Systemic Sclerosis-Related Pulmonary Arterial Hypertension Were Associated with Immunity, Inflammation, and Cytokines

Cardiovascular Therapeutics, 2021
Background. Pulmonary complications of systemic sclerosis (SSc), including pulmonary arterial hypertension (PAH), are the leading causes of patient death. However, the precise molecular mechanisms of its etiology are unclear.
Zhixiao Xu, Jiaxing Ruan, Lingyun Pan, Chengshui Chen   +3 more
doaj   +1 more source

Identification of VCAN as Hub Gene for Diabetic Kidney Disease Immune Injury Using Integrated Bioinformatics Analysis

Frontiers in Physiology, 2021
Background: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease in China. Tubular injury contributes to the progression of DKD.
Qiannan Xu, Binjue Li, Yucheng Wang, Cuili Wang, Shi Feng, Lu Xue, Jiang-Hua Chen, Hong Jiang   +7 more
semanticscholar   +1 more source

bianlab-hub/Chen_Sci_Adv_2022: enhancer

, 2022
Aberrations in tissue-specific enhancers underlie many developmental defects. Disrupting a noncoding region distal from the human SOX9 gene causes the Pierre Robin sequence (PRS) characterized by the undersized lower jaw.
bianlab-hub
core   +1 more source

Identification of Cancer Hub Gene Signatures Associated with Immune-Suppressive Tumor Microenvironment and Ovatodiolide as a Potential Cancer Immunotherapeutic Agent

Cancers, 2021
Simple Summary In order to identify common genes associated with the pathology of multiple cancers, we integrated differential expressed gene (DEGs) from datasets of six cancers (liver, lung colorectal, gastric, prostate, and breast cancers) and ...
Jia-Hong Chen, A. Wu, B. Lawal, David T. W. Tzeng, Jih-Chin Lee, C. Ho, T. Chao   +6 more
semanticscholar   +1 more source