Results 31 to 40 of about 245,963 (292)
ComHub: Community predictions of hubs in gene regulatory networks [PDF]
BMC Bioinformatics, 2019 AbstractSummaryHub transcription factors, regulating many target genes in gene regulatory networks (GRNs), play important roles as disease regulators and potential drug targets. However, while numerous methods have been developed to predict individual regulator-gene interactions from gene expression data, few methods focus on inferring these hubs.
Åkesson, Julia +3 more
openaire +6 more sources
Psoriasis Associated Hub Genes Revealed by Weighted Gene Co-Expression Network Analysis.
Cell journal, 2023 Psoriasis, an immune-mediated disorder, is a multifactorial disease with unidentified cause(s). This study aimed to discover possible biomarkers of this papulosquamous skin disease.The gene chip GSE55201, resulted from an experimental study, including 44 Psoriasis patients and 30 healthy controls was downloaded from GEO and weighted gene co-expression ...
Darvish, Zeinab +4 more
openaire +3 more sources
Journal of Immunology Research, 2023 Background. Kawasaki disease (KD) is characterized by a disordered inflammation response of unknown etiology. Immune cells are closely associated with its onset, although the immune-related genes’ expression and possibly involved immune regulatory ...
Hongjun Ba +10 more
doaj +1 more source
The propagation of perturbations in rewired bacterial gene networks [PDF]
, 2015 What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli.
Baumstark, R +7 more
core +1 more source
Frontiers in Physiology, 2017 Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li +14 more
doaj +1 more source
LongGeneDB: a data hub for long genes [PDF]
, 2020 ABSTRACTThe human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases. Specific mechanisms are utilized by long genes to facilitate their transcription and co-transcriptional processes ...
Sohyun Moon +3 more
openaire +1 more source
Hub Genes Associated with the Diagnosis of Diabetic Retinopathy
International Journal of General Medicine, 2021 This study aimed to identify genes that may be effective in diagnosing or treating diabetic retinopathy (DR), the most common complication of diabetes mellitus (DM).Differentially expressed genes (DEGs) were identified between DR and DM in GSE146615 dataset.
Yanhui Tang +6 more
openaire +5 more sources
Identification of the potential novel biomarkers as susceptibility gene for Wilms tumor
BMC Cancer, 2021 Background Wilms tumor (WT) is the most common malignant renal tumor in children. The aim of this study was to identify potential susceptibility gene of WT for better prognosis.
Li Liu +6 more
doaj +1 more source
Identification of potential biomarkers of vascular calcification using bioinformatics analysis and validation in vivo [PDF]
PeerJ, 2022 Background Vascular calcification (VC) is the most widespread pathological change in diseases of the vascular system. However, we know poorly about the molecular mechanisms and effective therapeutic approaches of VC.
Chuanzhen Chen +4 more
doaj +2 more sources
The pros and comms of gene sequencing [PDF]
, 2017 Full-gene sequencing undoubtedly comes with its pluses and its minuses. In this article, the authors aim to weigh up the pros and cons not only from the point of view of the patient but also in view of the doctor's possible perspective.
Codacci Pisanelli, Giovanni +3 more
core +2 more sources