Results 21 to 30 of about 245,963 (292)
Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration
Frontiers in Genetics, 2021 Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang +5 more
doaj +1 more source
Identification of Hub Genes in Tuberculosis via Bioinformatics Analysis [PDF]
Computational and Mathematical Methods in Medicine, 2021 Background. Tuberculosis (TB) is a serious chronic bacterial infection caused by Mycobacterium tuberculosis (MTB). It is one of the deadliest diseases in the world and a heavy burden for people all over the world. However, the hub genes involved in the host response remain largely unclear. Methods.
Tiancheng Zhang, Guihua Rao, Xiwen Gao
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Cardiovascular Therapeutics, 2021 Background. Pulmonary complications of systemic sclerosis (SSc), including pulmonary arterial hypertension (PAH), are the leading causes of patient death. However, the precise molecular mechanisms of its etiology are unclear.
Zhixiao Xu +3 more
doaj +1 more source
The Nuclear Lamina as a Gene-silencing Hub [PDF]
Current Issues in Molecular Biology, 2012 There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Shevelyov, Yuri Y., Nurminsky, Dmitry I.
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Text Mining and Hub Gene Network Analysis of Endometriosis [PDF]
BioMed Research International, 2021 This study is aimed at systematically characterizing the endometriosis‐associated genes based on text mining and at annotating the functions, pathways, and networks of endometriosis‐associated hub genes. We extracted endometriosis‐associated abstracts published between 1970 and 2020 from the PubMed database.
Yinuo Wang +4 more
openaire +2 more sources
Frontiers in Immunology, 2022 PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao +4 more
doaj +1 more source
Systematic identification of key functional modules and genes in esophageal cancer
Cancer Cell International, 2021 Background Esophageal cancer is associated with high incidence and mortality worldwide. Differential expression genes (DEGs) and weighted gene co-expression network analysis (WGCNA) are important methods to screen the core genes as bioinformatics methods.
Rui Wu +7 more
doaj +1 more source
cis-regulatory circuits regulating NEK6 kinase overexpression in transformed B cells Are super-enhancer independent [PDF]
, 2017 Alterations in distal regulatory elements that control gene expression underlie many diseases, including cancer. Epigenomic analyses of normal and diseased cells have produced correlative predictions for connections between dysregulated enhancers and ...
Huang, Yue +6 more
core +3 more sources
Frontiers in Genetics, 2023 Background: Fibrotic skin diseases are characterized by excessive accumulation of the extracellular matrix (ECM) and activation of fibroblasts, leading to a global healthcare burden. However, effective treatments of fibrotic skin diseases remain limited,
Ting Wu +9 more
doaj +1 more source
Frontiers in Genetics, 2021 ObjectiveThe aim of this study is the identification of hub genes associated with idiopathic pulmonary arterial hypertension (IPAH).Materials and MethodsGSE15197 gene expression data was downloaded from the Gene Expression Omnibus (GEO) database ...
Xue Qiu +5 more
doaj +1 more source