Results 21 to 30 of about 10,923,960 (347)

EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes

BMC Cardiovascular Disorders, 2022
Background Myocardial infarction (MI) is characterized by coronary artery occlusion, ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage.
Zhi-Xiang Bo, Shuwen Huang, Li Li, Lin Chen, Ping-Qian Chen, Xiaoyi Luo, F. Shi, Bing Zhu, Lin Shen   +8 more
semanticscholar   +1 more source

Identification of hub genes and construction of diagnostic nomogram model in schizophrenia

Frontiers in Aging Neuroscience, 2022
Schizophrenia (SCZ), which is characterized by debilitating neuropsychiatric disorders with significant cognitive impairment, remains an etiological and therapeutic challenge.
Chi Zhang, Naifu Dong, Shihan Xu, Haichun Ma, Min Cheng   +4 more
doaj   +1 more source

Identification of IMPA2 as the hub gene associated with colorectal cancer and liver metastasis by integrated bioinformatics analysis

Translational Oncology, 2022
Highlights • IMPA2 was selected as the hub gene associated with CRC and liver metastasis by integrated bioinformatics analysis.• The expression of IMPA2 was significantly decreased in CRC and liver metastasis samples, and low IMPA2 expression was ...
Liu-Li Wang, De-Ming Liu, Shuo Liu, Tianyi Liao, Yajun Jiao, Xianglai Jiang, Yongfeng Wang, Ya-Qiong Chen, Haizhong Ma, Hui Cai   +9 more
semanticscholar   +1 more source

Identification of potential hub genes of gastric cancer

Medicine, 2022
Abstract Background Gastric cancer (GC) is a malignant tumor originated from gastric mucosa epithelium. It is the third leading cause of cancer mortality in China. The early symptoms are not obvious. When it is discovered, it has developed to the advanced stage, and the prognosis is poor.
Xu-Dong Zhou, Ya-Wei Qu, Li Wang, Fu-Hua Jia, Peng Chen, Yin-Pu Wang, Hai-Feng Liu   +6 more
openaire   +2 more sources

Identification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease

Bioengineered, 2021
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), but the pathogenesis is not completely understood. Tubulointerstitial injury plays critical roles in the development and progression of
Yan Jia, Hui Xu, Qi Yu, L. Tan, Zu-Ying Xiong   +4 more
semanticscholar   +1 more source

Screening of potential hub genes in pulmonary thromboembolism

Experimental and Therapeutic Medicine, 2021
Pulmonary thromboembolism (PTE) is a fatal clinical syndrome that usually occurs in elderly individuals. The present study aimed to identify functional and key genes involved in the early diagnosis of PTE using bioinformatics analysis. The GSE84738 dataset was retrieved from the Gene Expression Omnibus database.
Lu, Yan, Dai, Jun, Liu, Qiyang, Cai, Pan, Zheng, Jianghua   +4 more
openaire   +3 more sources

Novel Drug Candidate Prediction for Intrahepatic Cholangiocarcinoma via Hub Gene Network Analysis and Connectivity Mapping

Cancers, 2022
Simple Summary Only about 15% of intrahepatic cholangiocarcinoma (ICC) patients meet the criteria for resection at the time of diagnosis. For patients with advanced and/or metastatic disease, the development of novel therapeutic strategies is urgently ...
Yao Xiao, Baoluhe Zhang, J. Cloyd, L. Alaimo, Gang Xu, S. Du, Yi-Lei Mao, T. Pawlik   +7 more
semanticscholar   +1 more source

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

Frontiers in Genetics, 2022
Endometriosis (EMs), one of the most common gynecological diseases, seriously affects the health and wellness of women; however, the underlying pathogenesis remains unclear.
Lu Li, Bo Sun, Yingpu Sun
semanticscholar   +1 more source

Prediction and validation of GUCA2B as the hub-gene in colorectal cancer based on co-expression network analysis: In-silico and in-vivo study.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
BACKGROUND Several serious attempts to treat colorectal cancer have been made in recent decades. However, no effective treatment has yet been discovered due to the complexities of its etiology.
Samira Nomiri, R. Hoshyar, Elham Chamani, Z. Rezaei, Fatemeh Salmani, Pegah Larki, T. Tavakoli, Faranak Gholipour, Neda Jalili Tabrizi, Afshin Derakhshani, M. Santarpia, T. Franchina, O. Brunetti, N. Silvestris, H. Safarpour   +14 more
semanticscholar   +1 more source

Identification of Hub Genes With Differential Correlations in Sepsis

Frontiers in Genetics, 2022
As a multifaceted syndrome, sepsis leads to high risk of death worldwide. It is difficult to be intervened due to insufficient biomarkers and potential targets. The reason is that regulatory mechanisms during sepsis are poorly understood. In this study, expression profiles of sepsis from GSE134347 were integrated to construct gene interaction network ...
Lulu Sheng, Yiqing Tong, Yi Zhang, Qiming Feng   +3 more
openaire   +3 more sources