Results 21 to 30 of about 125,991 (267)
Nuclear speckles: dynamic hubs of gene expression regulation [PDF]
The FEBS Journal, 2021 Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity.
İbrahim Avşar Ilık, Tuğçe Aktaş
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The Core Promoter Is a Regulatory Hub for Developmental Gene Expression [PDF]
Frontiers in Cell and Developmental Biology, 2021 The development of multicellular organisms and the uniqueness of each cell are achieved by distinct transcriptional programs. Multiple processes that regulate gene expression converge at the core promoter region, an 80 bp region that directs accurate transcription initiation by RNA polymerase II (Pol II).
Anna Sloutskin +3 more
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Frontiers in Genetics, 2023 Background: Fibrotic skin diseases are characterized by excessive accumulation of the extracellular matrix (ECM) and activation of fibroblasts, leading to a global healthcare burden. However, effective treatments of fibrotic skin diseases remain limited,
Ting Wu +9 more
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Systematic identification of key functional modules and genes in esophageal cancer
Cancer Cell International, 2021 Background Esophageal cancer is associated with high incidence and mortality worldwide. Differential expression genes (DEGs) and weighted gene co-expression network analysis (WGCNA) are important methods to screen the core genes as bioinformatics methods.
Rui Wu +7 more
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Frontiers in Genetics, 2021 ObjectiveThe aim of this study is the identification of hub genes associated with idiopathic pulmonary arterial hypertension (IPAH).Materials and MethodsGSE15197 gene expression data was downloaded from the Gene Expression Omnibus (GEO) database ...
Xue Qiu +5 more
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Network hub gene detection using the entire solution path information [PDF]
GeneticsMarkku Kuismin, Mikko J Sillanpää
exaly +2 more sources
ComHub: Community predictions of hubs in gene regulatory networks [PDF]
BMC Bioinformatics, 2019 Abstract Summary Hub transcription factors, regulating many target genes in gene regulatory networks (GRNs), play important roles as disease regulators and potential drug targets. However, while numerous methods have been developed to predict individual regulator-gene interactions from gene ...
Åkesson, Julia +3 more
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Text Mining and Hub Gene Network Analysis of Endometriosis [PDF]
BioMed Research International, 2021 This study is aimed at systematically characterizing the endometriosis‐associated genes based on text mining and at annotating the functions, pathways, and networks of endometriosis‐associated hub genes. We extracted endometriosis‐associated abstracts published between 1970 and 2020 from the PubMed database.
Yinuo Wang +4 more
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Frontiers in Physiology, 2017 Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li +14 more
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Identification of the potential novel biomarkers as susceptibility gene for Wilms tumor
BMC Cancer, 2021 Background Wilms tumor (WT) is the most common malignant renal tumor in children. The aim of this study was to identify potential susceptibility gene of WT for better prognosis.
Li Liu +6 more
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