Results 21 to 30 of about 124,378 (265)
Scientific Reports, 2022 Type 1 diabetes mellitus (T1DM) is a metabolic disorder for which the underlying molecular mechanisms remain largely unclear. This investigation aimed to elucidate essential candidate genes and pathways in T1DM by integrated bioinformatics analysis.
Madhu Pujar +4 more
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Journal of Translational Medicine, 2020 Background Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic for PTC are incomplete.
Yang Liu +5 more
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Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration
Frontiers in Genetics, 2021 Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang +5 more
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Identification of Hub Genes With Differential Correlations in Sepsis
Frontiers in Genetics, 2022 As a multifaceted syndrome, sepsis leads to high risk of death worldwide. It is difficult to be intervened due to insufficient biomarkers and potential targets. The reason is that regulatory mechanisms during sepsis are poorly understood. In this study, expression profiles of sepsis from GSE134347 were integrated to construct gene interaction network ...
Lulu Sheng +3 more
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Cardiovascular Therapeutics, 2021 Background. Pulmonary complications of systemic sclerosis (SSc), including pulmonary arterial hypertension (PAH), are the leading causes of patient death. However, the precise molecular mechanisms of its etiology are unclear.
Zhixiao Xu +3 more
doaj +1 more source
The nuclear lamina as a gene-silencing hub. [PDF]
Current issues in molecular biology, 2012 There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Yuri Y, Shevelyov, Dmitry I, Nurminsky
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Bioinformatic analysis of potential hub genes in gastric adenocarcinoma [PDF]
Science Progress, 2021 Gastric adenocarcinoma is the most common histologic type of gastric cancer; however, the pathogenic mechanisms remain unclear. To improve mechanistic understanding and identify new treatment targets or diagnostic biomarkers, we used bioinformatic tools to predict the hub genes related to the process of gastric adenocarcinoma development from public ...
Hao Liu +5 more
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Systematic identification of key functional modules and genes in esophageal cancer
Cancer Cell International, 2021 Background Esophageal cancer is associated with high incidence and mortality worldwide. Differential expression genes (DEGs) and weighted gene co-expression network analysis (WGCNA) are important methods to screen the core genes as bioinformatics methods.
Rui Wu +7 more
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Frontiers in Immunology, 2022 PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao +4 more
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Nuclear speckles: dynamic hubs of gene expression regulation [PDF]
The FEBS Journal, 2021 Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity.
İbrahim Avşar Ilık, Tuğçe Aktaş
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