Results 61 to 70 of about 245,963 (292)

Identification of hub genes related to prognosis in glioma [PDF]

Bioscience Reports, 2020
Abstract Glioma, a common malignant tumor of the central nervous system, has high invasiveness. The objective of the present study was to identify genes playing an important role in the development of glioma and to reveal their potential research value.
Delong Zhang, Jinxia Zhao, Chengzheng Han, Xiaocen Liu, Jun Liu, Hui Yang   +5 more
openaire   +2 more sources

Identification of TNFAIP6 as a hub gene associated with the progression of glioblastoma by weighted gene co‐expression network analysis

IET Systems Biology, 2022
This study aims to discover the genetic modules that distinguish glioblastoma multiforme (GBM) from low‐grade glioma (LGG) and identify hub genes. A co‐expression network is constructed using the expression profiles of 28 GBM and LGG patients from the ...
Dongdong Lin, Wei Li, Nu Zhang, Ming Cai
doaj   +1 more source

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. [PDF]

, 2015
Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities.
Amaral, David G, Bakken, Trygve E, Bennett, Jeffrey L, Bernard, Amy, Bertagnolli, Darren, Geschwind, Daniel H, Lee, Chang-Kyu, Lein, Ed S, Luo, Rui, Miller, Jeremy A, Parikshak, Neelroop N, Smith, Kimberly A, Sunkin, Susan M   +12 more
core   +1 more source

Identification of Immune-Related Hub Genes in Parkinson’s Disease

Frontiers in Genetics, 2022
Background: Parkinson’s disease (PD) is a common, age-related, and progressive neurodegenerative disease. Growing evidence indicates that immune dysfunction plays an essential role in the pathogenic process of PD. The objective of this study was to explore potential immune-related hub genes and immune infiltration patterns of PD.Method: The microarray ...
Lin Chen, Yong Wang, Juan Huang, Binbin Hu, Wei Huang   +4 more
openaire   +3 more sources

From access and integration to mining of secure genomic data sets across the grid [PDF]

, 2007
The UK Department of Trade and Industry (DTI) funded BRIDGES project (Biomedical Research Informatics Delivered by Grid Enabled Services) has developed a Grid infrastructure to support cardiovascular research.
Sinnott, R.O.
core   +2 more sources

Hub-Centered Gene Network Reconstruction Using Automatic Relevance Determination

PLoS ONE, 2012
Network inference deals with the reconstruction of biological networks from experimental data. A variety of different reverse engineering techniques are available; they differ in the underlying assumptions and mathematical models used. One common problem for all approaches stems from the complexity of the task, due to the combinatorial explosion of ...
M. Böck, S. Ogishima, H. Tanaka, S. Kramer, L. Kaderali   +4 more
openaire   +4 more sources

Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers

Scientific Reports, 2023
AbstractOsteoarthritis (OA) is a progressive cartilage degradation disease, concomitant with synovitis, osteophyte formation, and subchondral bone sclerosis. Over 37% of the elderly population is affected by OA, and the number of cases is increasing as the global population ages.
Junfeng Zeng, Xinhao Jiang, Mo Jiang, Yuexia Cao, Yi Jiang   +4 more
openaire   +3 more sources

Rutin Effects on Human Senescent Stromal Cells Function: a Network Analysis Study [PDF]

Research Journal of Pharmacognosy
Background and objectives: Rutin is a lipophilic natural flavonoid. It is found in vegetables, citrus fruits, and beverages. This study aims to evaluate rutin metabolic pathways in human senescent stromal cells.
Reza Robati, Fatemeh Bandarian, Farideh Razi, Zahra Razzaghi, Mohammad Rostami Nejad, Mitra Rezaei, Babak Arjmand, Vahid Mansouri*   +7 more
doaj   +1 more source

Identification of biomarkers for Barcelona Clinic Liver Cancer staging and overall survival of patients with hepatocellular carcinoma. [PDF]

PLoS ONE, 2018
The aim of the current study was to identify biomarkers that correlate with the Barcelona Clinic Liver Cancer (BCLC) staging system and prognosis of patients with hepatocellular carcinoma (HCC).
Wei Xu, Quan Rao, Yongbo An, Mengyi Li, Zhongtao Zhang   +4 more
doaj   +1 more source

ESRRG, ATP4A, and ATP4B as Diagnostic Biomarkers for Gastric Cancer: A Bioinformatic Analysis Based on Machine Learning

Frontiers in Physiology, 2022
Based on multiple bioinformatics methods and machine learning techniques, this study was designed to explore potential hub genes of gastric cancer with a diagnostic value.
Qiu Chen, Yu Wang, Yongjun Liu, Bin Xi
doaj   +1 more source