Results 61 to 70 of about 10,923,960 (347)
Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
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LongGeneDB: a data hub for long genes [PDF]
, 2020 ABSTRACT The human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases.
Sohyun Moon +3 more
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Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis
Frontiers in Genetics, 2022 The present study was performed to explore the underlying molecular mechanisms and screen hub genes of osteoarthritis (OA) via bioinformatics analysis. In total, twenty-five OA synovial tissue samples and 25 normal synovial tissue samples were derived from three datasets, namely, GSE55457, GSE55235, and GSE1919, and were used to identify the ...
Jian Zhou +9 more
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Hub gene associated with prognosis in bladder cancer is a novel therapeutic target [PDF]
PeerJ, 2023 Objective Bladder cancer is a clinical and social conundrum due to its high incidence and recurrence rate. It is urgent to find new targets for the diagnosis and treatment of bladder cancer and improve the prognosis and survival rate of bladder cancer ...
Dengpan Fang +4 more
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Journal of Immunology Research, 2023 Background. Kawasaki disease (KD) is characterized by a disordered inflammation response of unknown etiology. Immune cells are closely associated with its onset, although the immune-related genes’ expression and possibly involved immune regulatory ...
Hongjun Ba +10 more
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Rutin Effects on Human Senescent Stromal Cells Function: a Network Analysis Study [PDF]
Research Journal of PharmacognosyBackground and objectives: Rutin is a lipophilic natural flavonoid. It is found in vegetables, citrus fruits, and beverages. This study aims to evaluate rutin metabolic pathways in human senescent stromal cells.
Reza Robati +7 more
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Integrative analysis of ferroptosis-related genes in ulcerative colitis
Journal of International Medical Research, 2021 Objective The aim of this study was to identify and validate ferroptosis-related markers in ulcerative colitis (UC) to explore new directions for UC diagnosis and treatment.
De-jun Cui +4 more
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, 2023 Abstract Background The aim of this study was to identify hub genes, related transcription factors (TFs) and miRNAs from the miRNA–TF–gene interaction network in necrotizing enterocolitis (NEC). Methods Three expression data sets from GEO database that compared NEC with surgical negative controls were used to calculate differentially ...
Yuqian Su +6 more
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Hub genes and their key effects on prognosis of Burkitt lymphoma
World Journal of Clinical Oncology, 2023 Burkitt lymphoma (BL) is an exceptionally aggressive malignant neoplasm that arises from either the germinal center or post-germinal center B cells. Patients with BL often present with rapid tumor growth and require high-intensity multi-drug therapy combined with adequate intrathecal chemotherapy prophylaxis, however, a standard treatment program for ...
Xu, Yan-Feng +3 more
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Network Analyses of Differentially Expressed Genes in Osteoarthritis to Identify Hub Genes [PDF]
BioMed Research International, 2019 Background. Osteoarthritis (OA) is the most common degenerative disease in orthopedics. However, the cause and underlying molecular mechanisms are not clear. This study aims to identify the hub genes and pathways involved in the occurrence of osteoarthritis. Methods.
Zhaoyan Li +8 more
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