Results 21 to 30 of about 135,319 (315)

Clinical Values of the Identified Hub Genes in Systemic Lupus Erythematosus

Frontiers in Immunology, 2022
ObjectiveThis study was conducted to identify the biomarkers and mechanisms associated with systemic lupus erythematosus(SLE) at a transcriptome level.MethodsMicroarray datasets were downloaded, and differentially expressed genes (DEGs) were identified ...
Lu Xiao, Feng Zhan, Shudian Lin
doaj   +1 more source

Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation [PDF]

PeerJ, 2022
Background The mechanism of immunoglobulin A nephropathy (IgAN) is still unknown. A bioinformatics analysis is a powerful method to identify the biomarkers and possible therapeutic targets of a certain disease from related datasets.
Wu Jianping, Xiaona Wei, Jiajia Li, Rui Zhang, Qianqian Han, Qiongqiong Yang   +5 more
doaj   +2 more sources

Identification and Validation of Hub Genes in Hidradenitis Suppurativa. [PDF]

Clin Cosmet Investig Dermatol
Hidradenitis suppurativa (HS) is a severe, chronic inflammatory disease characterized by inflammatory nodules, progressive sinus tracts, and fistulas. Currently, its pathogenesis remain incompletely understood, and while diverse treatments are available, these have suboptimal efficacy.
Zhai YN, Cheng HY, Ma J, Feng CC, Zhang Q, Bu WB, Miao WJ, Shen H, Ji C.   +8 more
europepmc   +4 more sources

Identification of potential hub genes of gastric cancer

Medicine, 2022
Abstract Background Gastric cancer (GC) is a malignant tumor originated from gastric mucosa epithelium. It is the third leading cause of cancer mortality in China. The early symptoms are not obvious. When it is discovered, it has developed to the advanced stage, and the prognosis is poor.
Xu-Dong Zhou, Ya-Wei Qu, Li Wang, Fu-Hua Jia, Peng Chen, Yin-Pu Wang, Hai-Feng Liu   +6 more
openaire   +2 more sources

Identification of hub genes related to prognosis in glioma [PDF]

Bioscience Reports, 2020
Abstract Glioma, a common malignant tumor of the central nervous system, has high invasiveness. The objective of the present study was to identify genes playing an important role in the development of glioma and to reveal their potential research value.
Delong Zhang, Jinxia Zhao, Chengzheng Han, Xiaocen Liu, Jun Liu, Hui Yang   +5 more
openaire   +2 more sources

Screening of potential hub genes in pulmonary thromboembolism

Experimental and Therapeutic Medicine, 2021
Pulmonary thromboembolism (PTE) is a fatal clinical syndrome that usually occurs in elderly individuals. The present study aimed to identify functional and key genes involved in the early diagnosis of PTE using bioinformatics analysis. The GSE84738 dataset was retrieved from the Gene Expression Omnibus database.
Lu, Yan, Dai, Jun, Liu, Qiyang, Cai, Pan, Zheng, Jianghua   +4 more
openaire   +3 more sources

Integrated bioinformatics analysis of dendritic cells hub genes reveal potential early tuberculosis diagnostic markers

BMC Medical Genomics, 2023
Background Dendritic cells (DCs) are most potent antigen-processing cells and play key roles in host defense against Mycobacterium tuberculosis (MTB) infection.
Xiao Wu, Kewei Liu, Shanshan Li, Weicong Ren, Wei Wang, Yuanyuan Shang, Fuzhen Zhang, Yingying Huang, Yu Pang, Mengqiu Gao   +9 more
doaj   +1 more source

TGF-Beta Induced Key Genes of Osteogenic and Adipogenic Differentiation in Human Mesenchymal Stem Cells and MiRNA–mRNA Regulatory Networks

Frontiers in Genetics, 2021
Background: The clinical efficacy of osteoporosis therapy is unsatisfactory. However, there is currently no gold standard for the treatment of osteoporosis.
Genfa Du, Xinyuan Cheng, Zhen Zhang, Linjing Han, Keliang Wu, Yongjun Li, Xiaosheng Lin   +6 more
doaj   +1 more source

Identification of Hub Genes With Differential Correlations in Sepsis

Frontiers in Genetics, 2022
As a multifaceted syndrome, sepsis leads to high risk of death worldwide. It is difficult to be intervened due to insufficient biomarkers and potential targets. The reason is that regulatory mechanisms during sepsis are poorly understood. In this study, expression profiles of sepsis from GSE134347 were integrated to construct gene interaction network ...
Lulu Sheng, Yiqing Tong, Yi Zhang, Qiming Feng   +3 more
openaire   +3 more sources

The nuclear lamina as a gene-silencing hub. [PDF]

Current issues in molecular biology, 2012
There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Yuri Y, Shevelyov, Dmitry I, Nurminsky
openaire   +3 more sources