Results 41 to 50 of about 5,790,030 (310)

Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue

Frontiers in Cellular Neuroscience, 2023
Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs, Célia Raïs, Daniela Gaspar Santos, Daniela Gaspar Santos, Giulia Sansone, Stéphane Blanchard, Jean-Pierre Bourgeois, Bernd Jagla, Baptiste Saudemont, Laurène Schlick, Stéphanie Pons, Uwe Maskos   +11 more
doaj   +1 more source

Identification of key genes and biological pathways in Chinese lung cancer population using bioinformatics analysis [PDF]

PeerJ, 2022
Background Identification of accurate prognostic biomarkers is still particularly urgent for improving the poor survival of lung cancer patients.
Ping Liu, Hui Li, Chunfeng Liao, Yuling Tang, Mengzhen Li, Zhouyu Wang, Qi Wu, Yun Zhou   +7 more
doaj   +2 more sources

WGCNA Analysis Identifies the Hub Genes Related to Heat Stress in Seedling of Rice (Oryza sativa L.)

Genes, 2022
Frequent high temperature weather affects the growth and development of rice, resulting in the decline of seed–setting rate, deterioration of rice quality and reduction of yield.
Yubo Wang, Yingfeng Wang, Xiong Liu, Jieqiang Zhou, Hua-bing Deng, Guilian Zhang, Yunhua Xiao, Wen-bang Tang   +7 more
semanticscholar   +1 more source

The Core Promoter Is a Regulatory Hub for Developmental Gene Expression [PDF]

Frontiers in Cell and Developmental Biology, 2021
The development of multicellular organisms and the uniqueness of each cell are achieved by distinct transcriptional programs. Multiple processes that regulate gene expression converge at the core promoter region, an 80 bp region that directs accurate transcription initiation by RNA polymerase II (Pol II).
Anna Sloutskin, Hila Shir-Shapira, Richard N. Freiman, Tamar Juven-Gershon   +3 more
openaire   +3 more sources

Identification of Biomarkers Correlated with the TNM Staging and Overall Survival of Patients with Bladder Cancer

Frontiers in Physiology, 2017
Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li, Sheng Li, Sheng Li, Xiaoping Liu, Tongzu Liu, Xiangyu Meng, Xiaohong Yin, Cheng Fang, Di Huang, Yue Cao, Hong Weng, Xiantao Zeng, Xiantao Zeng, Xinghuan Wang, Xinghuan Wang   +14 more
doaj   +1 more source

Identification of hub genes and potential ceRNA networks of diabetic cardiomyopathy

Scientific Reports, 2023
Diabetic cardiomyopathy (DCM), a common complication of diabetes, is defined as ventricular dysfunction in the absence of underlying heart disease. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial ...
Jun Hou, Wan Yi Liang, S. Xiong, Pan Long, Tian Yue, Xudong Wen, Tianchen Wang, Haoyu Deng   +7 more
semanticscholar   +1 more source

Identification of novel immune subtypes and potential hub genes of patients with psoriasis

Journal of Translational Medicine, 2023
Background Psoriasis is a common, chronic and relapsing immune-related inflammatory dermal disease. Patients with psoriasis suffering from the recurrences is mainly caused by immune response disorder.
Yingxi Li, Lin Li, Junkai Huang, Li-Tao Zhang   +3 more
semanticscholar   +1 more source

Comprehensive analysis and validation of novel immune and vascular remodeling related genes signature associated with drug interactions in pulmonary arterial hypertension

Frontiers in Genetics, 2022
Background: Previous studies revealed that the gene signatures are associated with the modulation and pathogenesis of pulmonary arterial hypertension (PAH).
Jie Wang, Md. Nazim Uddin, Rui Wang, Yue-hong Gong, Yun Wu   +4 more
doaj   +1 more source

Identification of hub genes and pathways in lung metastatic colorectal cancer

BMC Cancer, 2023
Background Colorectal cancer (CRC) is one of the most prevalent types of malignant tumours. Metastasis is the leading cause of cancer-related mortality, with lung metastases accounting for 32.9% of all metastatic CRCs.
W. Dai, Caiyao Guo, Yu Wang, Yumei Li, Renjian Xie, Junhong Wu, Bao Yao, D. Xie, Ling He, Yingying Li, Hao Huang, Yun Wang, Shenglan Liu   +12 more
semanticscholar   +1 more source

Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers

Scientific Reports, 2023
Osteoarthritis (OA) is a progressive cartilage degradation disease, concomitant with synovitis, osteophyte formation, and subchondral bone sclerosis.
Junfeng Zeng, Xin Jiang, Mo Jiang, Yue Cao, Yi Jiang   +4 more
semanticscholar   +1 more source