Results 41 to 50 of about 8,236,393 (357)
Identification of hub genes and immune infiltration in ulcerative colitis using bioinformatics
Scientific Reports, 2023 Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine, whose pathogenesis is not fully understood. Given that immune infiltration plays a key role in UC progression, our study aimed to assess the level of immune cells in UC ...
Wei-Tao Hu +3 more
semanticscholar +1 more source
Nuclear speckles: dynamic hubs of gene expression regulation [PDF]
The FEBS Journal, 2021 Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity.
İbrahim Avşar Ilık, Tuğçe Aktaş
openaire +3 more sources
The nuclear lamina as a gene-silencing hub. [PDF]
Current issues in molecular biology, 2012 There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Yuri Y, Shevelyov, Dmitry I, Nurminsky
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Bioinformatics analysis: A roadmap to an aggressiveness model for Oral Squamous cell carcinoma key differentiated genes [PDF]
Alexandria Dental JournalIntroductionBioinformatics is a cross-disciplinary research field that combines computer science with biological science. The most fundamental yet frequently most impactful application of bioinformatics analysis is identifying variations in gene ...
Heba Mady +4 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundDiabetic nephropathy (DN) is the primary cause of end-stage renal disease, but existing therapeutics are limited. Therefore, novel molecular pathways that contribute to DN therapy and diagnostics are urgently needed.MethodsBased on the Gene ...
Mingming Xu +6 more
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Identification of key genes and biological pathways in Chinese lung cancer population using bioinformatics analysis [PDF]
PeerJ, 2022 Background Identification of accurate prognostic biomarkers is still particularly urgent for improving the poor survival of lung cancer patients.
Ping Liu +7 more
doaj +2 more sources
Identification ferroptosis-related hub genes and diagnostic model in Alzheimer’s disease
Frontiers in Molecular Neuroscience, 2023 Background Ferroptosis is a newly defined form of programmed cell death and plays an important role in Alzheimer’s disease (AD) pathology. This study aimed to integrate bioinformatics techniques to explore biomarkers to support the correlation between ...
Huabin Zhao +5 more
semanticscholar +1 more source
The Core Promoter Is a Regulatory Hub for Developmental Gene Expression [PDF]
Frontiers in Cell and Developmental Biology, 2021 The development of multicellular organisms and the uniqueness of each cell are achieved by distinct transcriptional programs. Multiple processes that regulate gene expression converge at the core promoter region, an 80 bp region that directs accurate transcription initiation by RNA polymerase II (Pol II).
Anna Sloutskin +3 more
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Frontiers in Physiology, 2017 Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li +14 more
doaj +1 more source
Identification and validation of ferroptosis-related hub genes in obstructive sleep apnea syndrome
Frontiers in Neurology, 2023 Background By 2020, the prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in the US has reached 26. 6–43.2% in men and 8.7–27.8% in women. OSAS promotes hypertension, diabetes, and tumor growth through unknown means. Chronic intermittent hypoxia (CIH)
Peijun Liu +5 more
semanticscholar +1 more source