Results 41 to 50 of about 2,288,692 (305)

Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis

Frontiers in Genetics, 2022
The present study was performed to explore the underlying molecular mechanisms and screen hub genes of osteoarthritis (OA) via bioinformatics analysis. In total, twenty-five OA synovial tissue samples and 25 normal synovial tissue samples were derived from three datasets, namely, GSE55457, GSE55235, and GSE1919, and were used to identify the ...
Jian Zhou, Dazhi Zou, Rongjun Wan, Rongjun Wan, Jie Liu, Qiong Zhou, Zhen Zhou, Wanchun Wang, Cheng Tao, Tang Liu   +9 more
openaire   +3 more sources

Identification of 13 Key Genes Correlated With Progression and Prognosis in Hepatocellular Carcinoma by Weighted Gene Co-expression Network Analysis

Frontiers in Genetics, 2020
Hepatocellular carcinoma (HCC) remains hard to diagnose early and cure due to a lack of accurate biomarkers and effective treatments. Hence, it is necessary to explore the tumorigenesis and tumor progression of HCC to discover new biomarkers for clinical
Yang Gu, Jun Li, Deliang Guo, Baiyang Chen, Pengpeng Liu, Yusha Xiao, Kang Yang, Zhisu Liu, Quanyan Liu   +8 more
doaj   +1 more source

Identification and Validation of Autophagy-Related Genes in Primary Ovarian Insufficiency by Gene Expression Profile and Bioinformatic Analysis

Analytical Cellular Pathology, 2022
Background. To investigate the relationship between primary ovarian insufficiency and autophagy, we detected and got the expression profile of human granulosa cell line SVOG, which was with or without LPS induced. The expression profile was analyzed with
Siji Lv, Jiani Sun, Jing Sun
doaj   +1 more source

united-manufacturing-hub/united-manufacturing-hub: 0.9.6 post release tag

, 2022
Tldr ⚠⚠⚠ ⚠⚠⚠ this is a test regarding permissions, please disregard this release for any kind of productive use ⚠⚠⚠ What's Changed build(deps): bump github.com/minio/minio-go/v7 from 7.0.29 to 7.0.34 in /golang by @dependabot in https://github.com ...
kruegeralex, Matteo Danelon, Ferdinand Linnenberg, JonaVo, PLC-Mercenary, Robert Feldmann, Lukas Hennies, ONUR CAN KARAMAN, larswitte, Matthew Judijanto, Pascal Bro, AMINE AMAACH, Derek Tiffany, Arne, Patrick Melichar, chrisproch, felixmhofmann, Jeremy Theocharis   +17 more
core   +1 more source

Identification of novel potential biomarkers in infantile hemangioma via weighted gene co-expression network analysis

BMC Pediatrics, 2022
Background Infantile hemangioma (IH) is the most common benign tumor in children and is characterized by endothelial cells proliferation and angiogenesis. Some hub genes may play a critical role in angiogenesis. This study aimed to identify the hub genes
Bin Xie, Xiongming Zhou, Jiaxuan Qiu
doaj   +1 more source

Integrated analysis of hub genes and miRNA- transcription factor-hub gene interaction network in necrotizing enterocolitis

, 2023
Abstract Background The aim of this study was to identify hub genes, related transcription factors (TFs) and miRNAs from the miRNA–TF–gene interaction network in necrotizing enterocolitis (NEC). Methods Three expression data sets from GEO database that compared NEC with surgical negative controls were used to calculate differentially ...
Yuqian Su, Chen Wang, Yang Yang, Zhaorong Huang, Caiyun Luo, Kai Wu, Liucheng Yang   +6 more
openaire   +1 more source

Enhanced construction of gene regulatory networks using hub gene information [PDF]

BMC Bioinformatics, 2017
Gene regulatory networks reveal how genes work together to carry out their biological functions. Reconstructions of gene networks from gene expression data greatly facilitate our understanding of underlying biological mechanisms and provide new opportunities for biomarker and drug discoveries.
Donghyeon Yu, Johan Lim, Xinlei Wang 0001, Faming Liang, Guanghua Xiao   +4 more
openaire   +2 more sources

Hub genes and their key effects on prognosis of Burkitt lymphoma

World Journal of Clinical Oncology, 2023
Burkitt lymphoma (BL) is an exceptionally aggressive malignant neoplasm that arises from either the germinal center or post-germinal center B cells. Patients with BL often present with rapid tumor growth and require high-intensity multi-drug therapy combined with adequate intrathecal chemotherapy prophylaxis, however, a standard treatment program for ...
Xu, Yan-Feng, Wang, Guan-Yun, Zhang, Ming-Yu, Yang, Ji-Gang   +3 more
openaire   +2 more sources

Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis

Frontiers in Aging Neuroscience, 2020
Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways.Methods: A co-expression network for an AD gene dataset with 401 ...
Rui-ting Hu, Qian Yu, Shao-dan Zhou, Yi-xin Yin, Rui-guang Hu, Hai-peng Lu, Bang-li Hu   +6 more
doaj   +1 more source

Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis

Frontiers in Immunology, 2023
BackgroundTo identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis.MethodsThe lipid metabolism-related hub genes were screened using machine learning algorithms, and the immune cell ...
Han She, Han She, Lei Tan, Lei Tan, Yi Wang, Yi Wang, Yuanlin Du, Yuanqun Zhou, Jun Zhang, Yunxia Du, Yunxia Du, Ningke Guo, Zhengbin Wu, Qinghui Li, Daiqin Bao, Qingxiang Mao, Yi Hu, Liangming Liu, Tao Li   +18 more
doaj   +1 more source