Results 41 to 50 of about 135,319 (315)
Frontiers in Cellular Neuroscience, 2023 Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs +11 more
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Network analysis based on TCGA reveals hub genes in colon cancer [PDF]
, 2017 Colorectal cancer (CRC) is the third most widespread cancer in the world. Although many advances have been made in molecular biology, novel approaches are still required to reveal molecular mechanisms for the diagnosis and therapy of colon cancer.
Junjie Chen +3 more
core +1 more source
ComHub: Community predictions of hubs in gene regulatory networks [PDF]
BMC Bioinformatics, 2019 Abstract Summary Hub transcription factors, regulating many target genes in gene regulatory networks (GRNs), play important roles as disease regulators and potential drug targets. However, while numerous methods have been developed to predict individual regulator-gene interactions from gene ...
Åkesson, Julia +3 more
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Frontiers in Genetics, 2020 Hepatocellular carcinoma (HCC) remains hard to diagnose early and cure due to a lack of accurate biomarkers and effective treatments. Hence, it is necessary to explore the tumorigenesis and tumor progression of HCC to discover new biomarkers for clinical
Yang Gu +8 more
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BMC Pediatrics, 2022 Background Infantile hemangioma (IH) is the most common benign tumor in children and is characterized by endothelial cells proliferation and angiogenesis. Some hub genes may play a critical role in angiogenesis. This study aimed to identify the hub genes
Bin Xie, Xiongming Zhou, Jiaxuan Qiu
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Heliyon, 2023 Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading cause of cancer death. The objective was to identify novel hub genes that were helpful for prognosis and targeted therapy in CRC. GSE23878, GSE24514, GSE41657, GSE81582
Min Guo, Xiaxi Li, Jiong Li, Baolong Li
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Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
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LongGeneDB: a data hub for long genes [PDF]
, 2020 ABSTRACT The human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases.
Sohyun Moon +3 more
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Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis
Frontiers in Genetics, 2022 The present study was performed to explore the underlying molecular mechanisms and screen hub genes of osteoarthritis (OA) via bioinformatics analysis. In total, twenty-five OA synovial tissue samples and 25 normal synovial tissue samples were derived from three datasets, namely, GSE55457, GSE55235, and GSE1919, and were used to identify the ...
Jian Zhou +9 more
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Text Mining and Hub Gene Network Analysis of Endometriosis [PDF]
BioMed Research International, 2021 This study is aimed at systematically characterizing the endometriosis‐associated genes based on text mining and at annotating the functions, pathways, and networks of endometriosis‐associated hub genes. We extracted endometriosis‐associated abstracts published between 1970 and 2020 from the PubMed database.
Yinuo Wang +4 more
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