Results 41 to 50 of about 198,026 (297)
The propagation of perturbations in rewired bacterial gene networks [PDF]
, 2015 What happens to gene expression when you add new links to a gene regulatory network? To answer this question, we profile 85 network rewirings in E. coli.
Baumstark, R +7 more
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Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
openaire +2 more sources
Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
Frontiers in Aging Neuroscience, 2020 Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways.Methods: A co-expression network for an AD gene dataset with 401 ...
Rui-ting Hu +6 more
doaj +1 more source
Scientific Reports, 2022 Despite advancements made in the therapeutic strategies on hepatocellular carcinoma (HCC), the survival rate of HCC patient is not satisfactory enough. Therefore, there is an urgent need for the valuable prognostic biomarkers in HCC therapy.
Zhifeng Lin +5 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundTo identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis.MethodsThe lipid metabolism-related hub genes were screened using machine learning algorithms, and the immune cell ...
Han She +18 more
doaj +1 more source
Systematic identification of functional plant modules through the integration of complementary data sources [PDF]
, 2012 A major challenge is to unravel how genes interact and are regulated to exert specific biological functions. The integration of genome-wide functional genomics data, followed by the construction of gene networks, provides a powerful approach to identify ...
Heyndrickx, Ken, Vandepoele, Klaas
core +2 more sources
, 2023 Abstract Background The aim of this study was to identify hub genes, related transcription factors (TFs) and miRNAs from the miRNA–TF–gene interaction network in necrotizing enterocolitis (NEC). Methods Three expression data sets from GEO database that compared NEC with surgical negative controls were used to calculate differentially ...
Yuqian Su +6 more
openaire +1 more source
Weighted-Lasso for Structured Network Inference from Time Course Data [PDF]
, 2009 We present a weighted-Lasso method to infer the parameters of a first-order vector auto-regressive model that describes time course expression data generated by directed gene-to-gene regulation networks. These networks are assumed to own a prior internal
Ambroise, Christophe +2 more
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Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes: a bioinformatics analysis [PDF]
International Journal of OphthalmologyAIM: To prevent neovascularization in diabetic retinopathy (DR) patients and partially control disease progression. METHODS: Hypoxia-related differentially expressed genes (DEGs) were identified from the GSE60436 and GSE102485 datasets, followed by gene ...
Cai-Han Yu +5 more
doaj +1 more source
Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. [PDF]
, 2017 Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture.
Ahn, Richard S +9 more
core +1 more source