Results 61 to 70 of about 5,790,030 (310)
Identification of hub genes for early detection of bone metastasis in breast cancer
Frontiers in Endocrinology, 2022 Background Globally, among all women, the most frequently detected and diagnosed and the most lethal type of cancer is breast cancer (BC). In particular, bone is one of the most frequent distant metastases 24in breast cancer patients and bone metastasis ...
Zitong Zhao +6 more
semanticscholar +1 more source
LongGeneDB: a data hub for long genes [PDF]
, 2020 ABSTRACT The human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases.
Sohyun Moon +3 more
openaire +1 more source
BMC Pediatrics, 2022 Background Infantile hemangioma (IH) is the most common benign tumor in children and is characterized by endothelial cells proliferation and angiogenesis. Some hub genes may play a critical role in angiogenesis. This study aimed to identify the hub genes
Bin Xie, Xiongming Zhou, Jiaxuan Qiu
doaj +1 more source
The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in glioma
BMC Cancer, 2022 Background Hexokinase 2 (HK2) is an enzyme that catalyses the conversion of glucose to glucose-6-phosphate, which has been found to be associated with malignant tumour growth.
Yishan Huang +6 more
semanticscholar +1 more source
Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
openaire +2 more sources
Scientific Reports, 2021 Despite responses to salinity stress in Dunaliella salina, a unicellular halotolerant green alga, being subject to extensive study, but the underlying molecular mechanism remains unknown.
B. Panahi, M. Hejazi
semanticscholar +1 more source
Exploration of the hub genes and miRNAs in lung adenocarcinoma
Oncology Letters, 2019 In order to investigate the oncogenic mechanisms of lung adenocarcinoma (LUAD), hub genes can be identified by constructing co-expression networks, and the potential linkages between hub genes, transcription factors (TFs) and microRNAs (miRNAs/miRs) can be visualized and identified.
Zhai, Yuanyuan +3 more
openaire +3 more sources
, 2023 Abstract Background The aim of this study was to identify hub genes, related transcription factors (TFs) and miRNAs from the miRNA–TF–gene interaction network in necrotizing enterocolitis (NEC). Methods Three expression data sets from GEO database that compared NEC with surgical negative controls were used to calculate differentially ...
Yuqian Su +6 more
openaire +1 more source
Enhanced construction of gene regulatory networks using hub gene information [PDF]
BMC Bioinformatics, 2017 Gene regulatory networks reveal how genes work together to carry out their biological functions. Reconstructions of gene networks from gene expression data greatly facilitate our understanding of underlying biological mechanisms and provide new opportunities for biomarker and drug discoveries.
Donghyeon Yu +4 more
openaire +2 more sources
Hub genes and their key effects on prognosis of Burkitt lymphoma
World Journal of Clinical Oncology, 2023 Burkitt lymphoma (BL) is an exceptionally aggressive malignant neoplasm that arises from either the germinal center or post-germinal center B cells. Patients with BL often present with rapid tumor growth and require high-intensity multi-drug therapy combined with adequate intrathecal chemotherapy prophylaxis, however, a standard treatment program for ...
Xu, Yan-Feng +3 more
openaire +2 more sources