Results 61 to 70 of about 198,026 (297)

Identification of Immune-Related Hub Genes in Parkinson’s Disease

Frontiers in Genetics, 2022
Background: Parkinson’s disease (PD) is a common, age-related, and progressive neurodegenerative disease. Growing evidence indicates that immune dysfunction plays an essential role in the pathogenic process of PD. The objective of this study was to explore potential immune-related hub genes and immune infiltration patterns of PD.Method: The microarray ...
Lin Chen, Yong Wang, Juan Huang, Binbin Hu, Wei Huang   +4 more
openaire   +3 more sources

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus. [PDF]

, 2020
Prefoldin (PFD) is a group II chaperonin that is ubiquitously present in the eukaryotic kingdom. Six subunits (PFD1-6) form a jellyfish-like heterohexameric PFD complex and function in protein folding and cytoskeleton organization.
Barry, Kerrie, Bryan, Anthony C, Chen, Jin-Gui, Collins, Cassandra M, Ding, Jinhua, Engle, Nancy L, Gunter, Lee E, Jawdy, Sara S, Li, Mi, Lindquist, Erika A, Muchero, Wellington, Pu, Yunqiao, Rottmann, William, Schmutz, Jeremy, Singan, Vasanth, Tschaplinski, Timothy J, Tuskan, Gerald A, Winkeler, Kimberly A, Xie, Meng, Yang, Xiaohan, Zhang, Jin   +20 more
core   +1 more source

Hub-Centered Gene Network Reconstruction Using Automatic Relevance Determination

PLoS ONE, 2012
Network inference deals with the reconstruction of biological networks from experimental data. A variety of different reverse engineering techniques are available; they differ in the underlying assumptions and mathematical models used. One common problem for all approaches stems from the complexity of the task, due to the combinatorial explosion of ...
M. Böck, S. Ogishima, H. Tanaka, S. Kramer, L. Kaderali   +4 more
openaire   +4 more sources

Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers

Scientific Reports, 2023
AbstractOsteoarthritis (OA) is a progressive cartilage degradation disease, concomitant with synovitis, osteophyte formation, and subchondral bone sclerosis. Over 37% of the elderly population is affected by OA, and the number of cases is increasing as the global population ages.
Junfeng Zeng, Xinhao Jiang, Mo Jiang, Yuexia Cao, Yi Jiang   +4 more
openaire   +3 more sources

Evaluation of genes and molecular pathway related pathogenesis of endometriosis: A bioinformatics approach

Informatics in Medicine Unlocked, 2023
Objective: Although recent studies have focused on the role of genes in the pathogenesis of endometriosis, the investigation of genes and molecular pathways involved in the pathogenesis of endometriosis with a bioinformatics approach has not been ...
Mahin Khalilzadeh Seivani, Noushin Modabber, Marzieh Shadpirouz, Bahareh Shateri Amiri, Parvane Bahoorzahi, Sahar Bahraminia   +5 more
doaj   +1 more source

Significance of hub genes and immune cell infiltration identified by bioinformatics analysis in pelvic organ prolapse [PDF]

PeerJ, 2020
Objective Pelvic organ prolapse (POP) refers to the decline of pelvic organ position and dysfunction caused by weak pelvic floor support. The aim of the present study was to screen the hub genes and immune cell infiltration related to POP disease ...
Ying Zhao, Zhijun Xia, Te Lin, Yitong Yin   +3 more
doaj   +2 more sources

Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence [PDF]

, 2013
Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind.
Blednov, Yuri A., Gorini, Giorgio, Harris, R. Adon, Mayfield, R. Dayne, Nunez, Yury O., Ponomareva, Olga N., Truitt, Jay M.   +6 more
core   +2 more sources

Discovering new hub genes of dilated cardiomyopathy

ESC Heart Failure
AbstractAimsDilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.MethodsTwo gene
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
openaire   +3 more sources

Study of Osteoarthritis‐Related Hub Genes Based on Bioinformatics Analysis [PDF]

BioMed Research International, 2020
Osteoarthritis (OA) is a common cause of morbidity and disability worldwide. However, the pathogenesis of OA is unclear. Therefore, this study was conducted to characterize the pathogenesis and implicated genes of OA. The gene expression profiles of GSE82107 and GSE55235 were downloaded from the Gene Expression Omnibus database.
Zhengqing Zhu, Lei Zhong, Ronghang Li, Yuzhe Liu, Xiangrun Chen, Zhaoyan Li, Lanfeng Huang   +6 more
openaire   +2 more sources