Results 71 to 80 of about 135,319 (315)

Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis

Frontiers in Immunology, 2022
BackgroundCalcific aortic valve disease (CAVD) is a progressive fibrocalcific disease that can be treated only through valve replacement. This study aimed to determine the role of hub genes and immune cell infiltration in CAVD progression.MethodsIn this ...
Kan Wang, Qiang Zheng, Xing Liu, BingChuan Geng, NianGuo Dong, JiaWei Shi   +5 more
doaj   +1 more source

Hub genes GWAS association.

, 2022
Genetic association of hub genes with the lung related traits and lung cancer from Phenoscanner database. (DOCX)
Ramu Elango (704627), Dalal Sameer Alshaer (13905757), Kawthar Saad Alghamdi (12877940), Babajan Banaganapalli (704628), Bayan Mallah (13905751), Nuha Alrayes (3474665), Noor A. Shaik (5147717), Walaa F. Albaqami (13905754)   +7 more
core   +1 more source

Identification of potential ferroptosis-associated biomarkers in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and gradual joint degeneration, resulting in function disability.
Xu He, Xu He, Juqi Zhang, Juqi Zhang, Juqi Zhang, Mingli Gong, Yanlun Gu, Yanlun Gu, Yanlun Gu, Bingqi Dong, Xiaocong Pang, Xiaocong Pang, Chenglong Zhang, Yimin Cui, Yimin Cui, Yimin Cui   +15 more
doaj   +1 more source

Integrated analysis of hub genes and miRNA- transcription factor-hub gene interaction network in necrotizing enterocolitis

, 2023
Abstract Background The aim of this study was to identify hub genes, related transcription factors (TFs) and miRNAs from the miRNA–TF–gene interaction network in necrotizing enterocolitis (NEC). Methods Three expression data sets from GEO database that compared NEC with surgical negative controls were used to calculate differentially ...
Yuqian Su, Chen Wang, Yang Yang, Zhaorong Huang, Caiyun Luo, Kai Wu, Liucheng Yang   +6 more
openaire   +1 more source

The parenting hub of the hypothalamus is a focus of imprinted gene action

PLOS Genetics, 2023
Imprinted genes are subject to germline epigenetic modification resulting in parental-specific allelic silencing. Although genomic imprinting is thought to be important for maternal behaviour, this idea is based on serendipitous findings from a small number of imprinted genes. Here, we undertook an unbiased systems biology approach, taking advantage of
Matthew J. Higgs, Anna E. Webberley, Alasdair J. Allan, Moaz Talat, Rosalind M. John, Anthony R. Isles   +5 more
openaire   +3 more sources

Identification of the hub genes RUNX2 and FN1 in gastric cancer [PDF]

Open Medicine, 2020
Abstract Background This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes. Methods
Han Chao, Jin Lei, Ma Xuemei, Hao Qin, Lin Huajun, Zhang Zhongtao   +5 more
openaire   +3 more sources

ROC curves of 10 hub genes.

, 2023
(A) Diagnostic value of hub genes in the GSE5281 dataset. (B) Diagnostic value of hub genes in the GSE48350 dataset.
Pengyun Ni (16792759), Bingbing Zhao (3589415), Kaiting Pan (16792762)   +2 more
core   +1 more source

Identification of hub genes predicting the development of prostate cancer from benign prostate hyperplasia and analyzing their clinical value in prostate cancer by bioinformatic analysis

Discover Oncology, 2022
Prostate cancer (PCa) and benign prostate hyperplasia (BPH) are commonly encountered diseases in males. Studies showed that genetic factors are responsible for the occurrences of both diseases.
Xi Chen, Junjie Ma, Chengdang Xu, Licheng Wang, Yicong Yao, Xinan Wang, Tong Zi, Cuidong Bian, Denglong Wu, Gang Wu   +9 more
doaj   +1 more source

Evaluation of genes and molecular pathway related pathogenesis of endometriosis: A bioinformatics approach

Informatics in Medicine Unlocked, 2023
Objective: Although recent studies have focused on the role of genes in the pathogenesis of endometriosis, the investigation of genes and molecular pathways involved in the pathogenesis of endometriosis with a bioinformatics approach has not been ...
Mahin Khalilzadeh Seivani, Noushin Modabber, Marzieh Shadpirouz, Bahareh Shateri Amiri, Parvane Bahoorzahi, Sahar Bahraminia   +5 more
doaj   +1 more source

Identification and Validation of Hub Genes in the Stenosis of Arteriovenous Fistula

Journal of Personalized Medicine, 2023
Arteriovenous fistula (AVF) is the most widely used hemodialysis vascular access in China. However, stenosis of the AVF limits its use. The mechanism of AVF stenosis is currently unknown. Therefore, the purpose of our study was to explore the mechanisms of AVF stenosis. In this study, we identified the differentially expressed genes (DEGs) based on the
Yu Li, Yue Chen, Wenhao Cui, Jukun Wang, Xin Chen, Chao Zhang, Linzhong Zhu, Chunjing Bian, Tao Luo   +8 more
openaire   +2 more sources