Results 91 to 100 of about 135,319 (315)

KEGG enrichment analysis for cancer hub genes.

, 2021
The x-axis is the gene ratio, which represents the percentage of all genes annotated to a pathway. Dot size is the number of genes annotated to a pathway. The color of each dot corresponds to the P-value of KEGG enrichment analysis.
Kui Chen (157443), Sihao Zhu (11636858), Xiao Ma (411875), Chunlong Zhong (3476660), Jiajun Qiu (4684921)   +4 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Exploring the association between rosacea and acne by integrated bioinformatics analysis

Scientific Reports
Clinically, rosacea occurs frequently in acne patients, which hints the existence of shared signals. However, the connection between the pathophysiology of rosacea and acne are not yet fully understood.
Jingchen Liang, Ying Chen, Zihao Wang, Yawen Wang, Shengzhi Mu, Dewu Zhang, Zhao Wang, Weihui Zeng   +7 more
doaj   +1 more source

Identification of uterine leiomyosarcoma-associated hub genes and immune cell infiltration pattern using weighted co-expression network analysis and CIBERSORT algorithm

World Journal of Surgical Oncology, 2021
Background While large-scale genomic analyses symbolize a precious attempt to decipher the molecular foundation of uterine leiomyosarcoma (ULMS), bioinformatics results associated with the occurrence of ULMS based totally on WGCNA and CIBERSORT have not ...
Xiaoqing Shen, Zhujuan Yang, Songwei Feng, Yi Li   +3 more
doaj   +1 more source

Identification of featured necroptosis-related genes and imbalanced immune infiltration in sepsis via machine learning

Frontiers in Genetics, 2023
Background: The precise diagnostic and prognostic biological markers were needed in immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in sepsis, differentially expressed necroptosis-related genes (DE-NRGs) were ...
Han She, Han She, Lei Tan, Lei Tan, Ruibo Yang, Jie Zheng, Yi Wang, Yi Wang, Yuanlin Du, Xiaoyong Peng, Qinghui Li, Haibin Lu, Xinming Xiang, Yi Hu, Liangming Liu, Tao Li   +15 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Linking Disulfide Levels and NAD+ Metabolism with Alzheimer’s Disease for Diagnostic Modeling and Target Drug Analysis

Journal of Integrative Neuroscience
Background: Alzheimer’s disease (AD) is a condition that affects the nervous system and that requires considerably more in-depth study. Abnormal Nicotinamide Adenine Dinucleotide (NAD+) metabolism and disulfide levels have been demonstrated in AD.
Yanbing Wang, Lining Su, Yongcai Zhang, Huiping Wei   +3 more
doaj   +1 more source

Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach

Scientific Reports, 2022
The primary objective of this investigation was to determine the hub genes of hepatocellular carcinoma (HCC) through an in silico approach. In the current context of the increased incidence of liver cancers, this approach could be a useful prognostic ...
Pradeep Kumar, Amit Kumar Singh, Kavindra Nath Tiwari, Sunil Kumar Mishra, Vishnu D. Rajput, Tatiana Minkina, Simona Cavalu, Ovidiu Pop   +7 more
doaj   +1 more source

Identification of Hub Genes Associated With Immune Infiltration and Predict Prognosis in Hepatocellular Carcinoma via Bioinformatics Approaches

Frontiers in Genetics, 2021
AimsIn the cancer-related research field, there is currently a major need for a greater number of valuable biomarkers to predict the prognosis of hepatocellular carcinoma (HCC).
Huaping Chen, Junrong Wu, Liuyi Lu, Zuojian Hu, Xi Li, Li Huang, Xiaolian Zhang, Mingxing Chen, Xue Qin, Li Xie   +9 more
doaj   +1 more source

Construction of the Interaction Network of Hub Genes in the Progression of Barrett’s Esophagus to Esophageal Adenocarcinoma

, 2023
Kai Li,1,2,* Peipei Duan,1,2,* Haifa He,3,* Ruijuan Du,1,2 Qian Wang,1,2 Pengju Gong,4 Hua Bian1 1Zhang Zhongjing College of Chinese Medicine, Nanyang Institute of Technology, Nanyang, Henan, People’s Republic of China; 2Henan Key Laboratory ...
Du R, Wang Q, Duan P, Gong P, He H, Bian H, Li K   +6 more
core