Results 91 to 100 of about 198,026 (297)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder

Experimental Biology and Medicine
Neurological pain (NP) is always accompanied by symptoms of depression, which seriously affects physical and mental health. In this study, we identified the common hub genes (Co-hub genes) and related immune cells of NP and major depressive disorder (MDD)
Jinjing Hu, Jinjing Hu, Jia Fu, Yuxin Cai, Yuxin Cai, Shuping Chen, Shuping Chen, Mengjian Qu, Mengjian Qu, Lisha Zhang, Lisha Zhang, Weichao Fan, Ziyi Wang, Qing Zeng, Qing Zeng, Jihua Zou, Jihua Zou, Jihua Zou   +17 more
doaj   +1 more source

Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach

Scientific Reports, 2022
The primary objective of this investigation was to determine the hub genes of hepatocellular carcinoma (HCC) through an in silico approach. In the current context of the increased incidence of liver cancers, this approach could be a useful prognostic ...
Pradeep Kumar, Amit Kumar Singh, Kavindra Nath Tiwari, Sunil Kumar Mishra, Vishnu D. Rajput, Tatiana Minkina, Simona Cavalu, Ovidiu Pop   +7 more
doaj   +1 more source

Large-scale inference and graph theoretical analysis of gene-regulatory networks in B. stubtilis

, 2006
We present the methods and results of a two-stage modeling process that generates candidate gene-regulatory networks of the bacterium B. subtilis from experimentally obtained, yet mathematically underdetermined microchip array data.
Albert, Anshuman Gupta, Barabasi, Christiansen, Christiansen, Claire Christensen, Costas D. Maranas, Csete, Dauner, Dauner, Dauner, Dauner, Dauner, D’Haeseleer, Gardner, Gavin, Giot, Guelzim, Gupta, Hartemink, Ho, Holter, Ito, Jeong, Kashtan, Latora, Latora, Lee, Li, Luscombe, Mangan, Mangan, Ma’ayan, Milo, Newman, Oltvai, Réka Albert, Sauer, Shen-Orr, Uetz, Vazquez, Yeung, Zaslaver   +42 more
core   +1 more source

DNA Methylation Heterogeneity Patterns in Breast Cancer Cell Lines [PDF]

, 2016
Heterogeneous DNA methylation patterns are linked to tumor growth. In order to study DNA methylation heterogeneity patterns for breast cancer cell lines, we comparatively study four metrics: variance, I² statistic, entropy, and methylation state.
Bertelsmann, Karina, Sun, Shuying, Sun, Shuying, Tian, Sunny, Yu, Linda   +4 more
core   +2 more sources

Gene's hubs in retinal diseases: A retinal disease network [PDF]

Heliyon, 2018
Retinal diseases associated with the dysfunction or death of photoreceptors are a major cause of blindness around the world, improvements in genetics tools, like next generation sequencing (NGS) allows the discovery of genes and genetic changes that lead to many of those retinal diseases.
J.M. Lázaro-Guevara, B.J. Flores-Robles, K. Garrido, V. Pinillos-Aransay, A. Elena-Ibáñez, L. Merino-Meléndez, J.A. López-Martínez, R. Victoriano-Lacalle   +7 more
openaire   +3 more sources

Comprehensive Analysis of Hub Genes In Prostate Cancer [PDF]

, 2021
Abstract Abstract：The present study aims to explore the involvement of hub genes in prostate cancer (PCa). Three series were used in this study: GSE46602, GSE5377, and GSE8511 from GPL570 platform in the Gene Expression Omnibus and the other resources from The Cancer Genome Atlas and UCSC Xena. A total of 47 differentially expressed genes (DEGs)
Zhi Yang, JUN MI
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Integrated Analysis of Multiple Microarrays Based on Raw Data Identified Novel Gene Signatures in Recurrent Implantation Failure

Frontiers in Endocrinology, 2022
BackgroundRecurrent implantation failure (RIF) is an intricate complication following IVF-ET, which refers to the situation that good-quality embryos repeatedly fail to implant following two or more IVF cycles.
Hong Zeng, Hong Zeng, Yu Fu, Lang Shen, Song Quan   +4 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source