Results 81 to 90 of about 198,026 (297)

The pros and comms of gene sequencing [PDF]

, 2017
Full-gene sequencing undoubtedly comes with its pluses and its minuses. In this article, the authors aim to weigh up the pros and cons not only from the point of view of the patient but also in view of the doctor's possible perspective.
Codacci Pisanelli, Giovanni, Esposito, Giovanni, Horgan, Denis, Moch, Holger   +3 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hub microRNAs and genes in the development of atrial fibrillation identified by weighted gene co-expression network analysis

BMC Medical Genomics, 2021
Co-expression network may contribute to better understanding molecular interaction patterns underlying cellular processes. To explore microRNAs (miRNAs) expression patterns correlated with AF, we performed weighted gene co-expression network analysis ...
Qiang Qu, Jin-Yu Sun, Zhen-Ye Zhang, Yue Su, Shan-Shan Li, Feng Li, Ru-Xing Wang   +6 more
doaj   +1 more source

Identification of Hub Genes Associated With Immune Infiltration and Predict Prognosis in Hepatocellular Carcinoma via Bioinformatics Approaches

Frontiers in Genetics, 2021
AimsIn the cancer-related research field, there is currently a major need for a greater number of valuable biomarkers to predict the prognosis of hepatocellular carcinoma (HCC).
Huaping Chen, Junrong Wu, Liuyi Lu, Zuojian Hu, Xi Li, Li Huang, Xiaolian Zhang, Mingxing Chen, Xue Qin, Li Xie   +9 more
doaj   +1 more source

Graph Theory and Networks in Biology [PDF]

, 2006
In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to ...
Mason, Oliver, Verwoerd, Mark
core   +3 more sources

Identification of Hub Genes With Differential Correlations in Sepsis

Frontiers in Genetics, 2022
As a multifaceted syndrome, sepsis leads to high risk of death worldwide. It is difficult to be intervened due to insufficient biomarkers and potential targets. The reason is that regulatory mechanisms during sepsis are poorly understood. In this study, expression profiles of sepsis from GSE134347 were integrated to construct gene interaction network ...
Lulu Sheng, Yiqing Tong, Yi Zhang, Qiming Feng   +3 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Linking Disulfide Levels and NAD+ Metabolism with Alzheimer’s Disease for Diagnostic Modeling and Target Drug Analysis

Journal of Integrative Neuroscience
Background: Alzheimer’s disease (AD) is a condition that affects the nervous system and that requires considerably more in-depth study. Abnormal Nicotinamide Adenine Dinucleotide (NAD+) metabolism and disulfide levels have been demonstrated in AD.
Yanbing Wang, Lining Su, Yongcai Zhang, Huiping Wei   +3 more
doaj   +1 more source

Network and biosignature analysis for the integration of transcriptomic and metabolomic data to characterize leaf senescence process in sunflower [PDF]

, 2016
In recent years, high throughput technologies have led to an increase of datasets from omics disciplines allowing the understanding of the complex regulatory networks associated with biological processes.
Di Rienzo, Julio Alejandro, Fernández, Paula del Carmen, Heinz, Ruth Amelia, Higgins, Janet, Moschen, Sebastián Nicolás, Paniego, Norma Beatriz   +5 more
core   +5 more sources

Hub genes of stroke identified by weighted gene co-expression network analysis [PDF]

, 2019
Abstract Background Microarray-based gene expression profiling has been widely used in biomedical research. Weighted gene co-expression network analysis (WGCNA) can link microarray data directly to clinical traits and to identify rules for predicting pathological stage and prognosis of disease, it has been found useful in many biological ...
Junhong Li, Yang Zhai, Peng Wu, Yueqiang Hu, Wei Chen, Jinghui Zheng, Nong Tang   +6 more
openaire   +2 more sources