Results 81 to 90 of about 5,790,030 (310)

Network Analyses of Differentially Expressed Genes in Osteoarthritis to Identify Hub Genes [PDF]

BioMed Research International, 2019
Background. Osteoarthritis (OA) is the most common degenerative disease in orthopedics. However, the cause and underlying molecular mechanisms are not clear. This study aims to identify the hub genes and pathways involved in the occurrence of osteoarthritis. Methods.
Zhaoyan Li, Lei Zhong, Zhenwu Du, Gaoyang Chen, Jing Shang, Qiwei Yang, Qingyu Wang, Yang Song, Guizhen Zhang   +8 more
openaire   +2 more sources

Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by the RNA-seq

Scientific Reports
Nano- and microplastics (NMPs) have become a serious global environmental threat that causes damage to mammalian organs. In this work, we investigated the potential molecular mechanism underlying the development of liver fibrosis induced by long-term ...
Qingwen Li, K. Zhu, Lizhi Huang, Xuan Niu, Lili Li, Likun Gao, Zhongyuan Xia   +6 more
semanticscholar   +1 more source

Identification of potential ferroptosis-associated biomarkers in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and gradual joint degeneration, resulting in function disability.
Xu He, Xu He, Juqi Zhang, Juqi Zhang, Juqi Zhang, Mingli Gong, Yanlun Gu, Yanlun Gu, Yanlun Gu, Bingqi Dong, Xiaocong Pang, Xiaocong Pang, Chenglong Zhang, Yimin Cui, Yimin Cui, Yimin Cui   +15 more
doaj   +1 more source

Integrative Bioinformatics Analysis for Targeting Hub Genes in Hepatocellular Carcinoma Treatment

Current Genomics
Background The damage in the liver and hepatocytes is where the primary liver cancer begins, and this is referred to as Hepatocellular Carcinoma (HCC).
Indu Priya Gudivada, Krishna Chaitanya Amajala   +1 more
semanticscholar   +1 more source

The parenting hub of the hypothalamus is a focus of imprinted gene action

PLOS Genetics, 2023
Imprinted genes are subject to germline epigenetic modification resulting in parental-specific allelic silencing. Although genomic imprinting is thought to be important for maternal behaviour, this idea is based on serendipitous findings from a small number of imprinted genes. Here, we undertook an unbiased systems biology approach, taking advantage of
Matthew J. Higgs, Anna E. Webberley, Alasdair J. Allan, Moaz Talat, Rosalind M. John, Anthony R. Isles   +5 more
openaire   +3 more sources

Prediction of interactomic hub genes in PBMC cells in type 2 diabetes mellitus, dyslipidemia, and periodontitis

BMC Oral Health
In recent years, the complex interplay between systemic health and oral well-being has emerged as a focal point for researchers and healthcare practitioners.
P. Yadalam, Deepavalli Arumuganainar, V. Ronsivalle, Marco Di Blasio, A. Badnjević, M. Marrapodi, G. Cervino, G. Minervini   +7 more
semanticscholar   +1 more source

Identification of hub genes for adult patients with sepsis via RNA sequencing

Scientific Reports, 2022
To screen out potential prognostic hub genes for adult patients with sepsis via RNA sequencing and construction of a microRNA–mRNA–PPI network and investigate the localization of these hub genes in peripheral blood monocytes.
Qian Zhang, Yingchun Hu, Pei-Shou Wei, Liu Shi, Lei Shi, Jianzhou Li, Yalei Zhao, Yunru Chen, Xi Zhang, F. Ye, Xiaojing Liu, Shumei Lin   +11 more
semanticscholar   +1 more source

Discovering New Hub Genes of Dilated Cardiomyopathy

ESC Heart Failure
Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified.
Jun-Yan Zhu, Yu Han, Jing-Yu Yang, De-Ping Wang, Li-Juan Gao, Teng Sun, Yan-Lin Feng, Zhong-Mei He, Bin Zhou, Ji-Min Cao   +9 more
openaire   +3 more sources

Identification and Validation of Hub Genes in the Stenosis of Arteriovenous Fistula

Journal of Personalized Medicine, 2023
Arteriovenous fistula (AVF) is the most widely used hemodialysis vascular access in China. However, stenosis of the AVF limits its use. The mechanism of AVF stenosis is currently unknown. Therefore, the purpose of our study was to explore the mechanisms of AVF stenosis. In this study, we identified the differentially expressed genes (DEGs) based on the
Yu Li, Yue Chen, Wenhao Cui, Jukun Wang, Xin Chen, Chao Zhang, Linzhong Zhu, Chunjing Bian, Tao Luo   +8 more
openaire   +2 more sources

Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis

Frontiers in Immunology, 2022
BackgroundCalcific aortic valve disease (CAVD) is a progressive fibrocalcific disease that can be treated only through valve replacement. This study aimed to determine the role of hub genes and immune cell infiltration in CAVD progression.MethodsIn this ...
Kan Wang, Qiang Zheng, Xing Liu, BingChuan Geng, NianGuo Dong, JiaWei Shi   +5 more
doaj   +1 more source