Results 81 to 90 of about 2,288,692 (305)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Exploring the association between rosacea and acne by integrated bioinformatics analysis

Scientific Reports
Clinically, rosacea occurs frequently in acne patients, which hints the existence of shared signals. However, the connection between the pathophysiology of rosacea and acne are not yet fully understood.
Jingchen Liang, Ying Chen, Zihao Wang, Yawen Wang, Shengzhi Mu, Dewu Zhang, Zhao Wang, Weihui Zeng   +7 more
doaj   +1 more source

Identification of the hub genes RUNX2 and FN1 in gastric cancer [PDF]

Open Medicine, 2020
Abstract Background This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes. Methods
Han Chao, Jin Lei, Ma Xuemei, Hao Qin, Lin Huajun, Zhang Zhongtao   +5 more
openaire   +3 more sources

Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: RECQL4/FAM13C Genes Address Common Hub Genes and Drugs [PDF]

Objective: The prevalence of breast cancer and gynaecological cancers is high, and these cancer types can occur consecutively as secondary cancers. The aim of our study is to determine the genes commonly expressed in these cancers and to identify the ...
Gizem Ayna Duran
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Identification of featured necroptosis-related genes and imbalanced immune infiltration in sepsis via machine learning

Frontiers in Genetics, 2023
Background: The precise diagnostic and prognostic biological markers were needed in immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in sepsis, differentially expressed necroptosis-related genes (DE-NRGs) were ...
Han She, Han She, Lei Tan, Lei Tan, Ruibo Yang, Jie Zheng, Yi Wang, Yi Wang, Yuanlin Du, Xiaoyong Peng, Qinghui Li, Haibin Lu, Xinming Xiang, Yi Hu, Liangming Liu, Tao Li   +15 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder

Experimental Biology and Medicine
Neurological pain (NP) is always accompanied by symptoms of depression, which seriously affects physical and mental health. In this study, we identified the common hub genes (Co-hub genes) and related immune cells of NP and major depressive disorder (MDD)
Jinjing Hu, Jinjing Hu, Jia Fu, Yuxin Cai, Yuxin Cai, Shuping Chen, Shuping Chen, Mengjian Qu, Mengjian Qu, Lisha Zhang, Lisha Zhang, Weichao Fan, Ziyi Wang, Qing Zeng, Qing Zeng, Jihua Zou, Jihua Zou, Jihua Zou   +17 more
doaj   +1 more source

Identification of uterine leiomyosarcoma-associated hub genes and immune cell infiltration pattern using weighted co-expression network analysis and CIBERSORT algorithm

World Journal of Surgical Oncology, 2021
Background While large-scale genomic analyses symbolize a precious attempt to decipher the molecular foundation of uterine leiomyosarcoma (ULMS), bioinformatics results associated with the occurrence of ULMS based totally on WGCNA and CIBERSORT have not ...
Xiaoqing Shen, Zhujuan Yang, Songwei Feng, Yi Li   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source