Results 111 to 120 of about 8,236,393 (357)

Identification of key hub genes in knee osteoarthritis through integrated bioinformatics analysis

Scientific Reports
Knee osteoarthritis (KOA) is a common chronic joint disease globally. Synovial inflammation plays a pivotal role in its pathogenesis, preceding cartilage damage.
Lilei Xu, Jiaqi Ma, Chuan-Long Zhou, Zhe Shen, Kean Zhu, Xue-Wen Wu, Yang Chen, Ting Chen, Xian-Ming Lin   +8 more
semanticscholar   +1 more source

Identification of hub genes for adult patients with sepsis via RNA sequencing

Scientific Reports, 2022
To screen out potential prognostic hub genes for adult patients with sepsis via RNA sequencing and construction of a microRNA–mRNA–PPI network and investigate the localization of these hub genes in peripheral blood monocytes.
Qian Zhang, Ying-Chun Hu, Pei-Shou Wei, Liu Shi, Lei Shi, Jian-Zhou Li, Ya-Lei Zhao, Yun-Ru Chen, Xi Zhang, F. Ye, Xiao-Jing Liu, Shu-Mei Lin   +11 more
semanticscholar   +1 more source

Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: RECQL4/FAM13C Genes Address Common Hub Genes and Drugs [PDF]

Objective: The prevalence of breast cancer and gynaecological cancers is high, and these cancer types can occur consecutively as secondary cancers. The aim of our study is to determine the genes commonly expressed in these cancers and to identify the ...
Gizem Ayna Duran, Duran, Assist. Prof. Dr. Gizem Ayna, Duran, Gizem Ayna   +2 more
core   +1 more source

Hub gene target of glioblastoma: LOX, SERPINH1 and TGFBI

Medicine, 2022
Glioblastoma (GBM) is a malignant tumor. The long-term prognosis of the patients is poor. Therefore, it is of important clinical value to further explore the pathogenesis and look for molecular markers for early diagnosis and targeted treatment.
Shuyuan Zhang, Weiwei Zhang, Bin Wu, Liang Xia, Liwen Li, Kai Jin, Yangfan Zou, Caixing Sun   +7 more
openaire   +2 more sources

Significance of hub genes and immune cell infiltration identified by bioinformatics analysis in pelvic organ prolapse [PDF]

PeerJ, 2020
Objective Pelvic organ prolapse (POP) refers to the decline of pelvic organ position and dysfunction caused by weak pelvic floor support. The aim of the present study was to screen the hub genes and immune cell infiltration related to POP disease ...
Ying Zhao, Zhijun Xia, Te Lin, Yitong Yin   +3 more
doaj   +2 more sources

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Identification and Validation of Hub Genes in Acute Pancreatitis and Hypertriglyceridemia

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022
The pathogenesis of acute pancreatitis (AP) and the relationship between acute pancreatitis and hypertriglyceridemia are complex and not fully understood. The purpose of this study was to identify the hub genes along with common differentially expressed genes (DEGs) between acute pancreatitis and hypertriglyceridemia.We downloaded three gene expression
Shiyu Zhang, Zhihai Liang, Xuelian Xiang, Li Liu, Huiying Yang, Guodu Tang   +5 more
openaire   +5 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Proximity of non-RAD hub genes to RAD genes.

, 2018
Proximity of non-RAD hub genes to RAD genes.
Mark Crovella (5131247), Lindsay A. Farrer (137611), Richard Mayeux (113225), Jonathan L. Haines (160079), Gerard D. Schellenberg (160086), Adam Naj (3233193), Margaret A. Pericak-Vance (160082), Daniel Lancour (5131244), Simon Kasif (2952)   +8 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source