Results 111 to 120 of about 135,319 (315)

The top 140 hub genes.

, 2023
The top 20 hub genes in the networks of each selected module, ranked by the MCC method. (DOCX)
Ali Moghadam (3148116), Fatemeh Amiri (9714476), Ahmad Tahmasebi (561590), Ali Niazi (102877)   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Identification of potential hub genes linked to immune and metabolic alterations in postoperative systemic inflammatory dysregulation

Frontiers in Immunology, 2023
BackgroundPostoperative systemic inflammatory dysregulation (PSID) is characterised by strongly interlinked immune and metabolic abnormalities. However, the hub genes responsible for the interconnections between these two systemic alterations remain to ...
Silu Cao, Jinxuan Tang, Miaomiao Fei, Qi Jing, Fanbing Meng, Meixian Zhang, Qidong Liu, Qidong Liu, Hui Zhang, Cheng Li   +9 more
doaj   +1 more source

A nine-hub-gene signature of metabolic syndrome identified using machine learning algorithms and integrated bioinformatics

, 2021
Early risk assessments and interventions for metabolic syndrome (MetS) are limited because of a lack of effective biomarkers. In the present study, several candidate genes were selected as a blood-based transcriptomic signature for MetS.
Sen Luo (402165), Xin Huang (11077), Kunzheng Wang (311238), Jianhua Wu (48701), Guanzhi Liu (11016411), Pei Yang (110623), Yutian Lei (737366), Zhuo Huang (167130)   +7 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Statistical analysis of hub genes’ parameters in different datasets.

, 2023
(A) Parametric statistical analysis of Hub genes in GSE8397. (B) Parametric statistical analysis of Hub genes in GSE49036. (C) Parametric statistical analysis of Hub genes in GSE20292.(D) Parametric statistical analysis of Hub genes in GSE7621.
Yanchi Fu (17583233), Tingting Yi (238503), Na Wang (193263), Kuo Tian (13148082), Huixue Zhang (614029), Jingyan Niu (17583230), Jianjian Wang (288375), Lihua Wang (14548), Qinghua Tian (614031), Lixia Chen (614030), Xuesong Sun (424554), Guanghao Xin (17583227)   +11 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

4 genes were identified as hub genes for PD.

, 2023
(A and B) The LASSO logistic regression algorithm selected six PD-related features. (C and D) mSVM-RFE algorithm to filter DEGs to identify the best combination of signature genes. Finally, 14 genes were identified as the best-characterized genes.
Yanchi Fu (17583233), Tingting Yi (238503), Na Wang (193263), Kuo Tian (13148082), Huixue Zhang (614029), Jingyan Niu (17583230), Jianjian Wang (288375), Lihua Wang (14548), Qinghua Tian (614031), Lixia Chen (614030), Xuesong Sun (424554), Guanghao Xin (17583227)   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Integrated bioinformatics and clinical data identify three novel biomarkers for osteoarthritis diagnosis and synovial immune

Scientific Reports
Osteoarthritis (OA) is a degenerative joint disease that can be aggravated by synovitis and synovial immune disorders (SID). However, the role of synovial SID-related genes in OA synovium remains poorly understood.
Zheng Zhu, Bizhi Tu, Cheng Peng, Xun Xu, Peizhi Lu, Rende Ning   +5 more
doaj   +1 more source