Results 111 to 120 of about 5,790,030 (310)

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder

Experimental Biology and Medicine
Neurological pain (NP) is always accompanied by symptoms of depression, which seriously affects physical and mental health. In this study, we identified the common hub genes (Co-hub genes) and related immune cells of NP and major depressive disorder (MDD)
Jinjing Hu, Jinjing Hu, Jia Fu, Yuxin Cai, Yuxin Cai, Shuping Chen, Shuping Chen, Mengjian Qu, Mengjian Qu, Lisha Zhang, Lisha Zhang, Weichao Fan, Ziyi Wang, Qing Zeng, Qing Zeng, Jihua Zou, Jihua Zou, Jihua Zou   +17 more
doaj   +1 more source

Identification of uterine leiomyosarcoma-associated hub genes and immune cell infiltration pattern using weighted co-expression network analysis and CIBERSORT algorithm

World Journal of Surgical Oncology, 2021
Background While large-scale genomic analyses symbolize a precious attempt to decipher the molecular foundation of uterine leiomyosarcoma (ULMS), bioinformatics results associated with the occurrence of ULMS based totally on WGCNA and CIBERSORT have not ...
Xiaoqing Shen, Zhujuan Yang, Songwei Feng, Yi Li   +3 more
doaj   +1 more source

Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma

Medicine, 2022
Background: Adamantinomatous craniopharyngioma (ACP) is a subtype of craniopharyngioma, a neoplastic disease with a benign pathological phenotype but a poor prognosis in the sellar region. The disease has been considered the most common congenital tumor in the skull. Therefore, this article aims to identify hub genes that might
Yang-Fan Zou, Shu-Yuan Zhang, Li-Weng Li, Kai Jing, Liang Xia, Cai-Xing Sun, Bin Wu   +6 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Linking Disulfide Levels and NAD+ Metabolism with Alzheimer’s Disease for Diagnostic Modeling and Target Drug Analysis

Journal of Integrative Neuroscience
Background: Alzheimer’s disease (AD) is a condition that affects the nervous system and that requires considerably more in-depth study. Abnormal Nicotinamide Adenine Dinucleotide (NAD+) metabolism and disulfide levels have been demonstrated in AD.
Yanbing Wang, Lining Su, Yongcai Zhang, Huiping Wei   +3 more
doaj   +1 more source

Integrated Analysis of Multiple Microarrays Based on Raw Data Identified Novel Gene Signatures in Recurrent Implantation Failure

Frontiers in Endocrinology, 2022
BackgroundRecurrent implantation failure (RIF) is an intricate complication following IVF-ET, which refers to the situation that good-quality embryos repeatedly fail to implant following two or more IVF cycles.
Hong Zeng, Hong Zeng, Yu Fu, Lang Shen, Song Quan   +4 more
doaj   +1 more source

Identification of Hub Genes and Immune-Related Pathways for Membranous Nephropathy by Bioinformatics Analysis

Frontiers in Physiology, 2022
OBJECTIVE: We aim to explore the detailed molecular mechanisms of membrane nephropathy (MN) related genes by bioinformatics analysis. METHODS: Two microarray datasets (GSE108109 and GSE104948) with glomerular gene expression data from 65 MN patients and ...
Xiaoya Cai, Zu-feng Wang, S. Ge, Gang Xu
semanticscholar   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Hub microRNAs and genes in the development of atrial fibrillation identified by weighted gene co-expression network analysis

BMC Medical Genomics, 2021
Co-expression network may contribute to better understanding molecular interaction patterns underlying cellular processes. To explore microRNAs (miRNAs) expression patterns correlated with AF, we performed weighted gene co-expression network analysis ...
Qiang Qu, Jin-Yu Sun, Zhen-Ye Zhang, Yue Su, Shan-Shan Li, Feng Li, Ru-Xing Wang   +6 more
doaj   +1 more source

Identification of hub genes and construction of diagnostic nomogram model in schizophrenia

Frontiers in Aging Neuroscience, 2022
Schizophrenia (SCZ), which is characterized by debilitating neuropsychiatric disorders with significant cognitive impairment, remains an etiological and therapeutic challenge.
Chi Zhang, Naifu Dong, Shihan Xu, Haichun Ma, M. Cheng   +4 more
semanticscholar   +1 more source