Results 121 to 130 of about 8,236,393 (357)

Exploring the association between rosacea and acne by integrated bioinformatics analysis

Scientific Reports
Clinically, rosacea occurs frequently in acne patients, which hints the existence of shared signals. However, the connection between the pathophysiology of rosacea and acne are not yet fully understood.
Jingchen Liang, Ying Chen, Zihao Wang, Yawen Wang, Shengzhi Mu, Dewu Zhang, Zhao Wang, Weihui Zeng   +7 more
doaj   +1 more source

Identification of uterine leiomyosarcoma-associated hub genes and immune cell infiltration pattern using weighted co-expression network analysis and CIBERSORT algorithm

World Journal of Surgical Oncology, 2021
Background While large-scale genomic analyses symbolize a precious attempt to decipher the molecular foundation of uterine leiomyosarcoma (ULMS), bioinformatics results associated with the occurrence of ULMS based totally on WGCNA and CIBERSORT have not ...
Xiaoqing Shen, Zhujuan Yang, Songwei Feng, Yi Li   +3 more
doaj   +1 more source

Identification of featured necroptosis-related genes and imbalanced immune infiltration in sepsis via machine learning

Frontiers in Genetics, 2023
Background: The precise diagnostic and prognostic biological markers were needed in immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in sepsis, differentially expressed necroptosis-related genes (DE-NRGs) were ...
Han She, Han She, Lei Tan, Lei Tan, Ruibo Yang, Jie Zheng, Yi Wang, Yi Wang, Yuanlin Du, Xiaoyong Peng, Qinghui Li, Haibin Lu, Xinming Xiang, Yi Hu, Liangming Liu, Tao Li   +15 more
doaj   +1 more source

Gene-coexpression network analysis identifies specific modules and hub genes related to cold stress in rice

BMC Genomics, 2021
When plants are subjected to cold stress, they undergo a series of molecular and physiological changes to protect themselves from injury. Indica cultivars can usually withstand only mild cold stress in a relatively short period.
Zhichi Zeng, Si-Chen Zhang, Wen-Yan Li, Bao-Shan Chen, Wen-Lan Li   +4 more
semanticscholar   +1 more source

Identification of the hub genes RUNX2 and FN1 in gastric cancer [PDF]

Open Medicine, 2020
Abstract Background This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes. Methods
Han Chao, Jin Lei, Ma Xuemei, Hao Qin, Lin Huajun, Zhang Zhongtao   +5 more
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Identification of Hub Genes Associated With Immune Infiltration and Predict Prognosis in Hepatocellular Carcinoma via Bioinformatics Approaches

Frontiers in Genetics, 2021
AimsIn the cancer-related research field, there is currently a major need for a greater number of valuable biomarkers to predict the prognosis of hepatocellular carcinoma (HCC).
Huaping Chen, Junrong Wu, Liuyi Lu, Zuojian Hu, Xi Li, Li Huang, Xiaolian Zhang, Mingxing Chen, Xue Qin, Li Xie   +9 more
doaj   +1 more source

The Identification and Validation of Hub Genes Associated with Acute Myocardial Infarction Using Weighted Gene Co-Expression Network Analysis

Journal of Cardiovascular Development and Disease, 2022
Acute myocardial infarction (AMI), one of the most severe and fatal cardiovascular diseases, remains the main cause of mortality and morbidity worldwide.
Junqiang Xue, L. Chen, Hao Cheng, Xiao-Yue Song, Yuekai Shi, Lin-Nan Li, Ren-De Xu, Q. Qin, Jian-Ying Ma, Jun-Bo Ge   +9 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder

Experimental Biology and Medicine
Neurological pain (NP) is always accompanied by symptoms of depression, which seriously affects physical and mental health. In this study, we identified the common hub genes (Co-hub genes) and related immune cells of NP and major depressive disorder (MDD)
Jinjing Hu, Jinjing Hu, Jia Fu, Yuxin Cai, Yuxin Cai, Shuping Chen, Shuping Chen, Mengjian Qu, Mengjian Qu, Lisha Zhang, Lisha Zhang, Weichao Fan, Ziyi Wang, Qing Zeng, Qing Zeng, Jihua Zou, Jihua Zou, Jihua Zou   +17 more
doaj   +1 more source