Results 121 to 130 of about 5,790,030 (310)

The Comprehensive Analysis of Hub Gene ARRB2 in Prostate Cancer

Disease Markers, 2022
Objects. As a frequent tumor in males, prostate adenocarcinoma (PRAD) results from the malignant proliferation of prostate epithelial cells. Here, we aim to investigate the latent pathogenesis of PRAD and find specific biomarkers for its treatment and prognosis. Methods.
Bing Zhou, Hong Song, Wuqin Xu, Yanbin Zhang, Yinhua Liu, Wei Qi   +5 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Identification of Hub Genes and Pathways Associated with Oxidative Stress of Cartilage in Osteonecrosis of Femoral Head Using Bioinformatics Analysis

Cartilage, 2022
Objective This study aimed to identify the hub genes and pathways of genes related to oxidative stress of cartilage in osteonecrosis of femoral head (ONFH), and to predict the transcription factors of the hub genes. Methods The GSE74089 was obtained from
W. Shi, Xinglong Zhang, Chunlei Xu, Ran Pang, Zhenqian Fan, Xin Wan, Zhaohui Jiang, Hui Li, Zhijun Li, Hua-feng Zhang   +9 more
semanticscholar   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Integrated bioinformatics and clinical data identify three novel biomarkers for osteoarthritis diagnosis and synovial immune

Scientific Reports
Osteoarthritis (OA) is a degenerative joint disease that can be aggravated by synovitis and synovial immune disorders (SID). However, the role of synovial SID-related genes in OA synovium remains poorly understood.
Zheng Zhu, Bizhi Tu, Cheng Peng, Xun Xu, Peizhi Lu, Rende Ning   +5 more
doaj   +1 more source

In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis

Evidence-Based Complementary and Alternative Medicine, 2022
Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes and reveal its molecular mechanism.
Arulprakasam Ajucarmelprecilla, Jhansi Pandi, Ranjithkumar Dhandapani, S. Ramanathan, Jayaprakash Chinnappan, R. Paramasivam, Sathiamoorthi Thangavelu, Abdul-Kareem Mohammed Ghilan, S. A. Aljohani, A. Oyouni, A. Farasani, Malik A. Altayar, HussamAwwadh E. Althagafi, O. Alzahrani, K. Durairaj, Anupama Shrestha   +15 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach

Scientific Reports, 2022
The primary objective of this investigation was to determine the hub genes of hepatocellular carcinoma (HCC) through an in silico approach. In the current context of the increased incidence of liver cancers, this approach could be a useful prognostic ...
Pradeep Kumar, Amit Kumar Singh, Kavindra Nath Tiwari, Sunil Kumar Mishra, Vishnu D. Rajput, Tatiana Minkina, Simona Cavalu, Ovidiu Pop   +7 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source