Results 141 to 150 of about 8,236,393 (357)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Identification of Novel Hub Genes Associated with Psoriasis Using Integrated Bioinformatics Analysis

International Journal of Molecular Sciences, 2022
Psoriasis is a chronic, prolonged, and recurrent inflammatory skin disease and the current therapeutics can only alleviate the symptoms rather than cure it completely.
Qi Yue, Z. Li, Qi Zhang, Quan-Xin Jin, Xinyuan Zhang, Guihua Jin   +5 more
semanticscholar   +1 more source

Hub gene interaction network.

, 2022
(A) Hub genes—transcription factors (TFs): The red spheres represent four hub genes; the blue squares represent six major hub genes-associated TFs and the cyan squares represent other gene-associated TFs; (B) Hub genes—miRNAs: red spheres represent four ...
Duy Ngoc Do (12446969), Truc Ly Nguyen (5352359), Thong Ba Nguyen (12446966), Tung Nguyen-Thanh (12446975), Thuy T. P. Nguyen (12446972), Ha Thi Nguyen (8937140)   +5 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Integrated bioinformatics and clinical data identify three novel biomarkers for osteoarthritis diagnosis and synovial immune

Scientific Reports
Osteoarthritis (OA) is a degenerative joint disease that can be aggravated by synovitis and synovial immune disorders (SID). However, the role of synovial SID-related genes in OA synovium remains poorly understood.
Zheng Zhu, Bizhi Tu, Cheng Peng, Xun Xu, Peizhi Lu, Rende Ning   +5 more
doaj   +1 more source

Number and Percentage of COSMIC Cancer-Specific Census Genes Identified by Critical Genes, Hub Genes, and DiffEx Genes.

, 2023
Number and Percentage of COSMIC Cancer-Specific Census Genes Identified by Critical Genes, Hub Genes, and DiffEx Genes.
Wenyuan Liao (6009893), Theodore Lun (17081588), Yang Yu (4292), Qing Li (84975), Pathum Kossinna (17081585), Qingrun Zhang (82414)   +5 more
core   +1 more source

Identification of Hub Genes in Colorectal Adenocarcinoma by Integrated Bioinformatics

Frontiers in Cell and Developmental Biology, 2022
An improved understanding of the molecular mechanism of colorectal adenocarcinoma is necessary to predict the prognosis and develop new target gene therapy strategies. This study aims to identify hub genes associated with colorectal adenocarcinoma and further analyze their prognostic significance. In this study, The Cancer Genome Atlas (TCGA) COAD-READ
Yang Liu, Lanlan Chen, Xiangbo Meng, Shujun Ye, Lianjun Ma   +4 more
openaire   +3 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Identifying Immune Cell Infiltration and Hub Genes During the Myocardial Remodeling Process After Myocardial Infarction

, 2023
Yuan Tian,1,* Zilin Wang,2,* Feng Liang,3,* Yi Wang1 1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People’s Republic of China; 2Department of Radiology, Shanghai ...
Liang F, Tian Y, Wang Y, Wang Z
core