Results 31 to 40 of about 2,288,692 (305)
Identification of key genes and biological pathways in Chinese lung cancer population using bioinformatics analysis [PDF]
PeerJ, 2022 Background Identification of accurate prognostic biomarkers is still particularly urgent for improving the poor survival of lung cancer patients.
Ping Liu +7 more
doaj +2 more sources
The Core Promoter Is a Regulatory Hub for Developmental Gene Expression [PDF]
Frontiers in Cell and Developmental Biology, 2021 The development of multicellular organisms and the uniqueness of each cell are achieved by distinct transcriptional programs. Multiple processes that regulate gene expression converge at the core promoter region, an 80 bp region that directs accurate transcription initiation by RNA polymerase II (Pol II).
Anna Sloutskin +3 more
openaire +3 more sources
Frontiers in Physiology, 2017 Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li +14 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: Previous studies revealed that the gene signatures are associated with the modulation and pathogenesis of pulmonary arterial hypertension (PAH).
Jie Wang +4 more
doaj +1 more source
Network analysis based on TCGA reveals hub genes in colon cancer [PDF]
, 2017 Colorectal cancer (CRC) is the third most widespread cancer in the world. Although many advances have been made in molecular biology, novel approaches are still required to reveal molecular mechanisms for the diagnosis and therapy of colon cancer.
Junjie Chen +3 more
core +1 more source
The environmental cost implication of hub-hub versus hub bypass flight networks [PDF]
, 2007 The increasing congestion at major hubs and the advantage to passengers of non-stop flights and faster journey times has intensified the debate on patterns of air service.
Morrell, Peter, Lu, Cherie
core +1 more source
ComHub: Community predictions of hubs in gene regulatory networks [PDF]
BMC Bioinformatics, 2019 Abstract Summary Hub transcription factors, regulating many target genes in gene regulatory networks (GRNs), play important roles as disease regulators and potential drug targets. However, while numerous methods have been developed to predict individual regulator-gene interactions from gene ...
Åkesson, Julia +3 more
openaire +6 more sources
Heliyon, 2023 Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading cause of cancer death. The objective was to identify novel hub genes that were helpful for prognosis and targeted therapy in CRC. GSE23878, GSE24514, GSE41657, GSE81582
Min Guo, Xiaxi Li, Jiong Li, Baolong Li
doaj +1 more source
Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
openaire +2 more sources
LongGeneDB: a data hub for long genes [PDF]
, 2020 ABSTRACT The human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases.
Sohyun Moon +3 more
openaire +1 more source