Results 31 to 40 of about 5,790,030 (310)
Identification of Hub Genes With Differential Correlations in Sepsis
Frontiers in Genetics, 2022 As a multifaceted syndrome, sepsis leads to high risk of death worldwide. It is difficult to be intervened due to insufficient biomarkers and potential targets. The reason is that regulatory mechanisms during sepsis are poorly understood. In this study, expression profiles of sepsis from GSE134347 were integrated to construct gene interaction network ...
Lulu Sheng +3 more
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Frontiers in Immunology, 2023 BackgroundDiabetic nephropathy (DN) is the primary cause of end-stage renal disease, but existing therapeutics are limited. Therefore, novel molecular pathways that contribute to DN therapy and diagnostics are urgently needed.MethodsBased on the Gene ...
Mingming Xu +6 more
doaj +1 more source
Frontiers in Oncology, 2023 Introduction Gastric cancer is one of the most common cancers in the world. This study aimed to identify genes, biomarkers, and metabolic pathways affecting gastric cancer using bioinformatic analysis and meta-analysis.
E. Darang +3 more
semanticscholar +1 more source
Seven key hub genes identified by gene co-expression network in cutaneous squamous cell carcinoma
BMC Cancer, 2021 Background Cutaneous squamous cell carcinoma (cSCC) often follows actinic keratosis (AK) and is the second most common skin cancer worldwide. To reduce metastasis risk, it is important to diagnose and treat cSCC early.
Huizhen Chen, Jiankang Yang, Wenjuan Wu
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Bioinformatic analysis of potential hub genes in gastric adenocarcinoma [PDF]
Science Progress, 2021 Gastric adenocarcinoma is the most common histologic type of gastric cancer; however, the pathogenic mechanisms remain unclear. To improve mechanistic understanding and identify new treatment targets or diagnostic biomarkers, we used bioinformatic tools to predict the hub genes related to the process of gastric adenocarcinoma development from public ...
Hao Liu +5 more
openaire +2 more sources
The nuclear lamina as a gene-silencing hub. [PDF]
Current issues in molecular biology, 2012 There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Yuri Y, Shevelyov, Dmitry I, Nurminsky
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Identification of Ten Core Hub Genes as Potential Biomarkers and Treatment Target for Hepatoblastoma
Frontiers in Oncology, 2021 BackgroundThis study aimed to systematically investigate gene signatures for hepatoblastoma (HB) and identify potential biomarkers for its diagnosis and treatment.Materials and MethodsGSE131329 and GSE81928 were obtained from the Gene Expression Omnibus (
Rui Sun +5 more
doaj +1 more source
Identification ferroptosis-related hub genes and diagnostic model in Alzheimer’s disease
Frontiers in Molecular Neuroscience, 2023 Background Ferroptosis is a newly defined form of programmed cell death and plays an important role in Alzheimer’s disease (AD) pathology. This study aimed to integrate bioinformatics techniques to explore biomarkers to support the correlation between ...
Huabin Zhao +5 more
semanticscholar +1 more source
Nuclear speckles: dynamic hubs of gene expression regulation [PDF]
The FEBS Journal, 2021 Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity.
İbrahim Avşar Ilık, Tuğçe Aktaş
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Bioinformatics analysis: A roadmap to an aggressiveness model for Oral Squamous cell carcinoma key differentiated genes [PDF]
Alexandria Dental JournalIntroductionBioinformatics is a cross-disciplinary research field that combines computer science with biological science. The most fundamental yet frequently most impactful application of bioinformatics analysis is identifying variations in gene ...
Heba Mady +4 more
doaj +1 more source