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Candidate Gene Association Analysis
2009Candidate gene association study is the most common method for associating human genetic variations with the phenotypes they produce, due to the relative simplicity of acquiring patient samples and genotype data. The study design begins with identifying appropriate DNA samples and an appropriate phenotype for analysis.
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Candidate gene prioritization.
Molecular genetics and genomics : MGG, 2012Candidate gene identification is typically labour intensive, involving laboratory experiments required to corroborate or disprove any hypothesis for a nominated candidate gene being considered the causative gene. The traditional approach to reduce the number of candidate genes entails fine-mapping studies using markers and pedigrees.
Ali, Masoudi-Nejad +3 more
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The Hexabrachion Gene as a Candidate for a Tuberous Sclerosis Gene
Annals of the New York Academy of Sciences, 1991J, Gulcher, K, Stefansson
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Poor replication of candidate genes for major depressive disorder using genome-wide association data
Molecular Psychiatry, 2010Eco de Geus +2 more
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Candidate-gene approaches for studying complex genetic traits: practical considerations
Nature Reviews Genetics, 2002Holly K Tabor
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