Results 121 to 130 of about 4,107,427 (327)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Jurnal Ilmu PemerintahanThis study aims to determine the framework related to the Government Policy of determining the Average weightage against each citizen of the country, which will decide the value or impact of the Individual Vote given to the Candidate by the Voter in the ...
Muhammad Younus +5 more
doaj +1 more source
Beware of a Naive Perspective: A Prebuttal to Possible U.S. Supreme Court Rulings in McCutcheon v. Federal Election Commission (Part 2) [PDF]
, 2014 Many believe that U.S. Supreme Court Chief Justice Roberts will provide the swing vote in the court's decision in Shaun McCutcheon v. Federal Election Commission (McCutcheon), a case challenging the constitutionality of caps on the total amount of ...
Adam Crowther, Taylor Lincoln
core
Comparing Election Methods Where Each Voter Ranks Only Few Candidates
, 2019 Election rules are formal processes that aggregate voters preferences, typically to select a single candidate, called the winner. Most of the election rules studied in the literature require the voters to rank the candidates from the most to the least ...
Bentert, Matthias, Skowron, Piotr
core +1 more source
Where Do Recent Small Molecule Clinical Development Candidates Come From?
Journal of Medicinal Chemistry, 2018 An analysis of 66 published clinical candidates from Journal of Medicinal Chemistry has been conducted to shed light on which lead generation strategies are most frequently employed in identifying drug candidates.
Dean G. Brown, Jonas Boström
semanticscholar +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Comparing candidates’ beliefs and exam performance in speaking tests
Language Value, 2019 Author/s Cristina Pérez-Guillot Julia Zabala-Delgado Universitat Politècnica de València, Spain ABSTRACT The development of a language exam is not a linear process but rather a round cycle in which, by using the test, we obtain information ...
lvalue lvalue
doaj +1 more source
Picturing Teacher Agency: Developing Upstanding Heuristics in a Middle Grades Social Studies Methods Course [PDF]
, 2019 This paper presents a multi-case study of teacher candidates in a pre-service middle grades social studies methods course. The research aimed to understand how the middle grades teacher candidates viewed their future as upstanders with agency in middle ...
Farley, Jennifer, Gallagher, Jennifer L
core +2 more sources
Review of the experimental evidence on pentaquarks and critical discussion
, 2004 We review and discuss the experimental evidence on predicted baryonic states made by 4 quarks and one antiquark, called pentaquarks. Theoretical and experimental advances in the last few years led to the observation of pentaquark candidates by some ...
Kabana, Sonia
core +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source