Results 51 to 60 of about 4,822 (160)

A Complex Microbial Interplay Underlies Recurrent Vulvovaginal Candidiasis Pathobiology

mSystems, 2021
While extremely prevalent, painful, and difficult to treat, vulvovaginal candidiasis remains largely understudied in the field of women’s health. In a recent issue of mSystems, McKloud et al. (E. McKloud, C. Delaney, L. Sherry, R.
Nicolas Papon, Patrick Van Dijck
doaj   +1 more source

A Phase I, First‐In‐Human Study of CBA‐1205, an Anti‐DLK1 Monoclonal Antibody, in Patients With Advanced Solid Tumors

Cancer Science, Volume 116, Issue 4, Page 1012-1022, April 2025.
We conducted a Phase I trial of CBA‐1205, a novel monoclonal antibody targeting DLK1, in advanced solid tumors, demonstrating safety and tolerability with no dose‐limiting toxicities. Preliminary efficacy was observed, with six patients achieving stable disease for over 6 months, and sDLK1 was identified as a potential biomarker associated with ...
Yuki Katsuya, Masafumi Ikeda, Takafumi Koyama, Jun Sato, Mao Okada, Nobuaki Matsubara, Chihiro Kondoh, Toru Mukohara, Kazuo Watanabe, Daisuke Kotani, Yoshimi Ogawa, Shose Taoka, Noboru Yamamoto   +12 more
wiley   +1 more source

Use of natamycin and ketoconazole suppositories in the treatment of recurrent vulvovaginal candidiasis [PDF]

РМЖ. Мать и дитя, 2018
Use of natamycin and ketoconazole suppositories in the treatment  of recurrent vulvovaginal candidiasis I.I. Ivanova1, Yu.E. Dobrokhotova2 1 Pirogov Russian National Research Medical University, Moscow, Russian Federation 2 Clinical ...
I.I. Ivanova, Yu.E. Dobrokhotova
doaj  

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu, Tong Shen, Paz Martin Herrero, Chao‐Xing Yuan, Samirah Qureshi, Xiaoyu Jiang, Ye Sheng, Christoph Gasteyger, Yang Dai   +8 more
wiley   +1 more source

Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis [PDF]

Vestnik Dermatologii i Venerologii
The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to ...
Margarita R. Rakhmatulina, Elena V. Lipova, Viktoria A. Nyanenko   +2 more
doaj   +1 more source

Allergen‐Specific Immunotherapy and Trained Immunity

Allergy, Volume 80, Issue 3, Page 677-689, March 2025.
ABSTRACT The high prevalence of allergic diseases reached over the last years is attributed to the complex interplay of genetic factors, lifestyle changes, and environmental exposome. Allergen‐specific immunotherapy (AIT) is the single therapeutic strategy for allergic diseases with the potential capacity to modify the course of the disease.
Leticia Martín‐Cruz, Oscar Palomares
wiley   +1 more source

The Dermatology Life Quality Index (DLQI) used as the benchmark in validation of 101 quality‐of‐life instruments: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 3, Page 631-679, March 2025.
This study systematically analysed peer‐reviewed publications describing use of the DLQI in validation of other PRO and QoL measures and identified widespread use of the DLQI as a benchmark in validation of other dermatology PRO/QoL measures. It confirms the central role DLQI plays in the development of novel instruments and validation across ...
J. Vyas, J. R. Johns, Y. Abdelrazik, F. M. Ali, J. R. Ingram, S. Salek, A. Y. Finlay   +6 more
wiley   +1 more source

Treatment of recurrent vulvovaginal candidiasis in women planning a pregnancy [PDF]

РМЖ. Мать и дитя, 2018
Treatment of recurrent vulvovaginal candidiasis in women planning a pregnancy Borovikov I.O., Kutsenko I.I., Gerasimenko E.E. Kuban State Medical University, Krasnodar Aim: evaluation of treatment methods for recurrent vulvovaginal candidiasis ...
Borovikov I.O., Kutsenko I.I., E.E. Gerasimenko   +2 more
doaj  

Efficacy and Safety of Intravenous Secukinumab for the Treatment of Active Psoriatic Arthritis: Results From a Randomized, Placebo‐Controlled Phase 3 Study

Arthritis &Rheumatology, Volume 77, Issue 2, Page 171-179, February 2025.
Objective The aim of this study was to evaluate the efficacy and safety of intravenous (IV) secukinumab in patients with active psoriatic arthritis (PsA). Methods INVIGORATE‐2 (NCT04209205) was a randomized, placebo‐controlled, phase 3 trial. Patients with active PsA were randomized 1:1 to receive IV secukinumab (6 mg/kg at baseline followed by 3 mg/kg
Alan Kivitz, Liliana Sedova, Melvin Churchill, Roshan Kotha, Atul Singhal, Alexander Torres, Guillermo Valenzuela, Sarah Whelan, Thomas Dumortier, Xuan Zhu, Ruvie Martin, Luminita Pricop   +11 more
wiley   +1 more source

Vulvovaginal candidiasis [PDF]

Sexually Transmitted Infections, 2006
D J, White, A, Vanthuyne
openaire   +4 more sources