Results 101 to 110 of about 608 (157)

Corrective GUSB transfer to the canine mucopolysaccharidosis VII brain

, 2014
International audienceSevere deficiency in lysosomal β-glucuronidase (β-glu) enzymatic activity results in mucopolysaccharidosis (MPS) VII, an orphan disease with symptoms often appearing in early childhood.
Cherel, Y., Bayo-Puxan, Neus, Bernex, F., Vite, Charles, Colle, M. A., Cherel, Yan, Skander, N., Serratrice, Nicolas, Haskins, M. E., Gennetier, Aurelie, Joussemet, B., Mennechet, Franck, Kalatzis, V., Skander, Nadia, Kremer, E. J., Kalatzis, Vasiliki, Bernex, Florence, Gennetier, A., Bayo-Puxan, N., Mennechet, F., Ibanes, Sandy, Mazouni, Khalil, Lajat, Y., Ibanes, S., Kremer, Eric J., Vite, C., Cubizolle, A., Joussemet, Béatrice, Lajat, Yaouen, Colle, Marie-Anne, Serratrice, N., Mazouni, K., Cubizolle, Aurelie, Haskins, Mark E.   +33 more
core   +1 more source

Transductional retargeting of human adenovirus type 5 to ανβ6 integrin for cancer gene therapy

, 2009
PhDA key impediment to successful cancer therapy with adenoviral vectors is the inefficient transduction of malignant tissue in vivo. Compounding this problem is the lack of cancer-specific targets, coupled with a shortage of corresponding high ...
Coughlan, Lynda
core  

Immunogenicity of a novel inactivated canine adenovirus type 2 variant vaccine for dogs

Clinical and Experimental Vaccine Research
The immunogenicity of vaccines containing the canine adenovirus (CAdV) type 2 (CAdV-2) variant has not yet been reported. We prepared a novel inactivated CAdV-2 variant vaccine using the CAV2232-41 strain, and evaluated its safety and immunogenicity in raccoon dogs.The growth kinetics of CAV2232-41 were determined using Madin-Darby Canine Kidney (MDCK)
Dong-Kun Yang, Sangjin Ahn, Hye Jeong Lee, Minuk Kim, Jong-Taek Kim, Ju-Yeon Lee, Yun Sang Cho   +6 more
openaire   +2 more sources

Trafficking and propagation of canine adenovirus vectors lacking a known integrin-interacting motif

, 2001
Canine adenovirus type 2 (CAV-2) vectors may be attractive tools for gene transfer thanks to the lack of preexisting immunity in humans, and because of the preferential transduction of neurons when the vector is injected into the brain and some ...
Chillon, M., Kremer, E. J.
core   +1 more source

Development of Multiplex PCR assay for detection of Canine Infectious Respiratory Disease Complex (CIRDC) pathogens in dogs

Frontiers in Cellular and Infection Microbiology
BackgroundCanine Infectious Respiratory Disease Complex (CIRDC) is a highly contagious, multifactorial syndrome that primarily affects dogs in crowded environments such as shelters, kennels, and breeding facilities. Three major CIRDC-associated pathogens:
Ritik Kaul, Jai Bhagwan, Kanisht Batra, Parveen Kumar, Divya Agnihotri   +4 more
doaj   +1 more source

Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques

, 2002
The feasibility, safety, and efficacy of liver-directed gene transfer was evaluated in 5 male macaques (aged 2.5 to 6.5 years) by using a recombinant adeno-associated viral (rAAV) vector (rAAV-2 CAGG-hFIX) that had previously mediated persistent ...
Hanawa, H, Ng, CYC, Mandrell, TD, Vanin, EF, Nathwani, AC, Hu, Y, Davidoff, AM, Hoffer, FA, Zhou, J, Slaughter, C, Nikanorov, A, Lozier, JN, Nienhuis, AW   +12 more
core  

High prevalence of antibodies against canine adenovirus (CAV) type 2in domestic dog populations in South Africa precludes the use of CAV-based recombinant rabies vaccines

, 2013
Rabies in dogs can be controlled through mass vaccination. Oral vaccination of domestic dogs would beuseful in the developing world, where greater vaccination coverage is needed especially in inaccessibleareas or places with large numbers of free-roaming
Jackson, F.R., Wright, Nicolette, Ellison, J.A., Niezgoda, Michael, Nel, Louis Hendrik, Rupprecht, Charles Edward   +5 more
core   +1 more source

Canine adenovirus nephropathy [PDF]

, 1975
The purpose of the present investigation was to carry out a detailed histological, immunofluorescence and ultrastructural study of the renal lesions which occur during canine adenovirus (CAV) infection.
Morrison, William Ivan
core  

The detection of canine adenovirus infections by means of polymerase chain reaction method

, 2019
The object of this study was to establish canine adenoviruses and evaluate prevalence among sick and clinically healthy dogs by clinical and molecular biology-based methods and health effects. The study consists of 43 pages, including 4 tables, 14 images,
Štarolytė, Evelina
core  

Editorial: Tropism, Mapping, Modeling, or Therapy Using Canine Adenovirus Type 2 (CAV-2) Vectors in the CNS

Frontiers in Molecular Neuroscience, 2021
Iria Gonzalez Dopeso-Reyes, Mathieu Wolff, Melissa R. Andrews, Eric J. Kremer   +3 more
doaj   +1 more source