Results 1 to 10 of about 28,821 (216)

Transduction of Craniofacial Motoneurons Following Intramuscular Injections of Canine Adenovirus Type-2 (CAV-2) in Rhesus Macaques [PDF]

Frontiers in Neuroanatomy, 2019
Reliable viral vector-mediated transgene expression in primate motoneurons would improve our ability to anatomically and physiologically interrogate motor systems.
Martin O. Bohlen, Hala G. El-Nahal, Marc A. Sommer, Marc A. Sommer   +3 more
doaj   +5 more sources

CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems [PDF]

Frontiers in Molecular Neuroscience, 2019
The options available for genetic modification of cells of the central nervous system (CNS) have greatly increased in the last decade. The current panoply of viral and nonviral vectors provides multifunctional platforms to deliver expression cassettes to
Danila del Rio, Bertrand Beucher, Marina Lavigne, Amani Wehbi, Iria Gonzalez Dopeso-Reyes, Isabella Saggio, Isabella Saggio, Eric J. Kremer   +7 more
doaj   +7 more sources

Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups. [PDF]

PLoS ONE, 2015
Brain gene transfer using viral vectors will likely become a therapeutic option for several disorders. Helper-dependent (HD) canine adenovirus type 2 vectors (CAV-2) are well suited for this goal.
Stefania Piersanti, Romina Burla, Valerio Licursi, Catarina Brito, Mattia La Torre, Paula M Alves, Daniel Simao, Carla Mottini, Sara Salinas, Rodolfo Negri, Enrico Tagliafico, Eric J Kremer, Isabella Saggio   +12 more
doaj   +7 more sources

Downregulation of Caveolin-2 Is a Novel Mechanism Involved in Activation of Inducible Nitric Oxide Synthase (iNOS) in Mouse Peritoneal Macrophages [PDF]

Mediators of Inflammation
Here we report that membrane protein caveolin-2 (Cav-2) is regulated during activation of primary mouse peritoneal macrophages and RAW264.7 macrophage cell line by a bacterial lipopolysaccharide (LPS) and a cytokine, interferon gamma (IFN-γ).
Sungchan Jang, Grzegorz Sowa
doaj   +2 more sources

Molecular detection of canine viral infectious diseases in China: an investigation from 2018 to 2024 [PDF]

Frontiers in Veterinary Science
To analyze the prevalence of canine viral diseases in China, including canine parvovirus type 2 (CPV-2), canine coronavirus (CCoV), canine distemper virus (CDV), canine herpesvirus type 1 (CHV-1), canine parainfluenza virus (CPIV), canine influenza virus
Caihong Liu, Caihong Liu, Caihong Liu, Yalei Chen, Yalei Chen, Ningning Cui, Ningning Cui, Yihang Yang, Yihang Yang, Hangtian Ding, Hangtian Ding, Hongchao Wu, Hongchao Wu, Yuxiu Liu, Yuxiu Liu, Kegong Tian, Kegong Tian, Xingang Xu   +17 more
doaj   +2 more sources

Evaluation of a Point-of-Care Test for Pre-Vaccination Testing to Detect Antibodies against Canine Adenoviruses in Dogs

Viruses, 2021
(1) Background: Antibody testing is commonly used to assess a dog’s immune status. For detection of antibodies against canine adenoviruses (CAVs), one point-of-care (POC) test is available. This study assessed the POC test´s performance.
Michèle Bergmann, Mike Holzheu, Yury Zablotski, Stephanie Speck, Uwe Truyen, Katrin Hartmann   +5 more
doaj   +1 more source

Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity [PDF]

International Neurourology Journal, 2021
Purpose Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear.
Tae Jin Cho, Da-Hyun Lee, Bo-Hwa Choi, Helen K. Shinn, Chang-Shin Park   +4 more
doaj   +1 more source

L-Type Ca²⁺ Channel Regulation by Calmodulin and CaBP1

Biomolecules, 2021
L-type voltage-gated Ca2+ channels (CaV1.2 and CaV1.3, called CaV) interact with the Ca2+ sensor proteins, calmodulin (CaM) and Ca2+ binding Protein 1 (CaBP1), that oppositely control Ca2+-dependent channel activity. CaM and CaBP1 can each bind to the IQ-
James B. Ames
doaj   +1 more source

Role of Caveolae family-related proteins in the development of breast cancer

Frontiers in Molecular Biosciences, 2023
Breast cancer has become the most significant malignant tumor threatening women’s lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell
Qinyu Han, Shi Qiu, Huiwen Hu, Wenjing Li, Xiangqi Li   +4 more
doaj   +1 more source

Canine adenovirus type 2 vector generation via I-Sce1-mediated intracellular genome release. [PDF]

PLoS ONE, 2013
When canine adenovirus type 2 (CAdV-2, or also commonly referred to as CAV-2) vectors are injected into the brain parenchyma they preferentially transduce neurons, are capable of efficient axonal transport to afferent regions, and allow transgene ...
Sandy Ibanes, Eric J Kremer
doaj   +1 more source