Results 1 to 10 of about 24,469,413 (266)

Transduction of Craniofacial Motoneurons Following Intramuscular Injections of Canine Adenovirus Type-2 (CAV-2) in Rhesus Macaques [PDF]

Frontiers in Neuroanatomy, 2019
Reliable viral vector-mediated transgene expression in primate motoneurons would improve our ability to anatomically and physiologically interrogate motor systems.
Martin O. Bohlen, Hala G. El-Nahal, Marc A. Sommer, Marc A. Sommer   +3 more
doaj   +6 more sources

CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems. [PDF]

Front Mol Neurosci, 2019
The options available for genetic modification of cells of the central nervous system (CNS) have greatly increased in the last decade. The current panoply of viral and nonviral vectors provides multifunctional platforms to deliver expression cassettes to many structures and nuclei.
Del Rio D, Beucher B, Lavigne M, Wehbi A, Gonzalez Dopeso-Reyes I, Saggio I, Kremer EJ.   +6 more
europepmc   +9 more sources

CAV-2-Mediated GFP and LRRK2^G2019S Expression in the Macaca fascicularis Brain. [PDF]

Front Mol Neurosci, 2020
Parkinson's disease is characterized by motor and nonmotor symptoms that gradually appear as a consequence of the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Currently, no treatment can slow Parkinson's disease progression.
di Caudo C, Martínez-Valbuena I, Mundiñano IC, Gennetier A, Hernandez M, Carmona-Abellan M, Marcilla Garcia I, Kremer EJ, Luquin R.   +8 more
europepmc   +6 more sources

Targeting Catecholaminergic Systems in Transgenic Rats With a CAV-2 Vector Harboring a Cre-Dependent DREADD Cassette. [PDF]

Front Mol Neurosci, 2020
Techniques that allow the manipulation of specific neural circuits have greatly increased in the past few years. DREADDs (Designer receptors exclusively activated by designer drugs) provide an elegant way to manipulate individual brain structures and/or neural circuits, including neuromodulatory pathways. Considerable efforts have been made to increase
Cerpa JC, Marchand AR, Salafranque Y, Pape JR, Kremer EJ, Coutureau E.   +5 more
europepmc   +5 more sources

Targeting Reciprocally Connected Brain Regions Through CAV-2 Mediated Interventions. [PDF]

Front Mol Neurosci, 2019
An important issue in contemporary neuroscience is to identify functional principles at play within neural circuits. The reciprocity of the connections between two distinct brain areas appears as an intriguing feature of some of these circuits. This organization has been viewed as "re-entry," a process whereby two or more brain regions concurrently ...
Morceau S, Piquet R, Wolff M, Parkes SL.
europepmc   +5 more sources

Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy? [PDF]

Diagnostics
Background: CAV (cardiac allograft vasculopathy) is considered the leading cause of late post-transplant mortality and affects approximately 50% of transplant patients at 10 years post-transplant. Its etiopathogenetic mechanism is considered to be immune-
Anca Otilia Farcas, Mihai Ciprian Stoica, Septimiu Voidazan, Carmen Corina Radu, Laszlo Hadadi, Liviu Gavrilovici, Horatiu Suciu, Anca Ileana Sin   +7 more
doaj   +2 more sources

Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups. [PDF]

PLoS ONE, 2015
Brain gene transfer using viral vectors will likely become a therapeutic option for several disorders. Helper-dependent (HD) canine adenovirus type 2 vectors (CAV-2) are well suited for this goal.
Stefania Piersanti, Romina Burla, Valerio Licursi, Catarina Brito, Mattia La Torre, Paula M Alves, Daniel Simao, Carla Mottini, Sara Salinas, Rodolfo Negri, Enrico Tagliafico, Eric J Kremer, Isabella Saggio   +12 more
doaj   +8 more sources

Editorial: Tropism, Mapping, Modeling, or Therapy Using Canine Adenovirus Type 2 (CAV-2) Vectors in the CNS. [PDF]

Front Mol Neurosci, 2021
Dopeso-Reyes IG, Wolff M, Andrews MR, Kremer EJ.   +3 more
europepmc   +6 more sources

Preclinical Safety Evaluation of a Replication-Defective Canine Adenovirus Type 2 Vector-Based SARS-CoV-2 Vaccine Candidate in Murine Models [PDF]

Vaccines
Background: Adenoviral vectors are widely used in vaccine development; however, pre-existing immunity to common human adenovirus serotypes can limit their effectiveness.
Denis Omara, Christian Ndekezi, Susan Mugaba, Angella Nakyanzi, Fortunate Natwijuka, Anne Kapaata, Frank Kato, Drake Byamukama, David E. Ggwaabya, Orla Mugulusi, Freddie Bwanga, David P. Katete, Enock Matovu, Joseph Olobo, Ekii Andrew Obuku, Obondo James Sande, Jennifer Serwanga, Stephen Cose, Pontiano Kaleebu, Sheila N. Balinda   +19 more
doaj   +2 more sources

Caveolin-1 Modulates Islet Amyloid Polypeptide Expression Through Interaction with TXNIP in Murine Pancreatic β-Cells [PDF]

Biomedicines
Background: Pathological aggregation of islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in type 2 diabetes. Our previous studies demonstrated that caveolin-1 (Cav-1) deficiency protects β-cells from palmitate-induced apoptosis ...
Kunying Liu, Xubin Yang, Shuo Lin, Chuwen Lin, Nan Cai, Longyi Zeng, Wen Zeng   +6 more
doaj   +2 more sources