Results 51 to 60 of about 24,544,793 (183)

Assessment and development of adenovirus type 11 for cancer therapy [PDF]

, 2010
PhDThe efficacy of oncolytic virotherapy is influenced by the interactions between the tumour, virus and host immunity. The first generation of oncolytic adenoviruses, based on serotype 5 (Ad5), has achieved limited success in clinical trials.
Wong, Han Hsi
core   +4 more sources

Validation of a real-time PCR panel for detection and quantification of nine pathogens commonly associated with canine infectious respiratory disease

MethodsX, 2023
Canine infectious respiratory disease (CIRD) is a complicated respiratory syndrome in dogs [1–3]. A panel PCR was developed [4] to detect nine pathogens commonly associated with CIRD: Mycoplasma cynos, Mycoplasma canis, Bordetella bronchiseptica; canine ...
Junsheng Dong, Wai Ning Tiffany Tsui, Xue Leng, Jinping Fu, Molly Lohman, Joseph Anderson, Vaughn Hamill, Nanyan Lu, Elizabeth Poulsen Porter, Mark Gray, Tesfaalem Sebhatu, Susan Brown, Roman Pogranichniy, Heng Wang, Lance Noll, Jianfa Bai   +15 more
doaj   +1 more source

Transduction of Craniofacial Motoneurons Following Intramuscular Injections of Canine Adenovirus Type-2 (CAV-2) in Rhesus Macaques

Frontiers in Neuroanatomy, 2019
Reliable viral vector-mediated transgene expression in primate motoneurons would improve our ability to anatomically and physiologically interrogate motor systems.
Martin O. Bohlen, Hala G. El-Nahal, Marc A. Sommer, Marc A. Sommer   +3 more
doaj   +1 more source

Canine morbillivirus (canine distemper virus) with concomitant canine adenovirus, canine parvovirus-2, and Neospora caninum in puppies: a retrospective immunohistochemical study [PDF]

Scientific Reports, 2018
AbstractA retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals were reviewed to determine ...
Selwyn A. Headley, Thalita E. S. Oliveira, Alfredo H. T. Pereira, Jéssica R. Moreira, Mariana M. Z. Michelazzo, Bárbara G. Pires, Victor Hugo B. Marutani, Ana A. C. Xavier, Giovana W. Di Santis, João L. Garcia, Amauri A. Alfieri   +10 more
openaire   +2 more sources

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors [PDF]

Journal of Visualized Experiments, 2013
Adenovirus (Ad) derived vectors have been widely used for short or long-term gene transfer, both for gene therapy and vaccine applications. Because of the frequent pre-existing immunity against the classically used human adenovirus type 5, canine adenovirus type 2 (CAV2) has been proposed as an alternative vector for human gene transfer.
Szelechowski, Marion, Bergeron, Corinne, Gonzalez-Dunia, Daniel, Klonjkowski, Bernard   +3 more
openaire   +4 more sources

Multiplex PCR methods for detection of several viruses associated with canine respiratory and enteric diseases.

PLoS ONE, 2019
Viral respiratory and intestinal infections are the most common causes of canine viral illness. Infection with multiple pathogens occurs in many cases. Rapid diagnosis of these multiple infections is important for providing timely and effective treatment.
Xiangqi Hao, Ruohan Liu, Yuwei He, Xiangyu Xiao, Weiqi Xiao, Qingxu Zheng, Xi Lin, Pan Tao, Pei Zhou, Shoujun Li   +9 more
doaj   +1 more source

Evaluation of tumor immunity after administration of conditionally replicative adenoviral vector in canine osteosarcoma patients

Heliyon, 2021
Osteosarcoma is one among the most common neoplasms in dogs. Current treatments show limited efficacy and fail to prevent metastasis. Conditionally replicative adenoviruses (CRAd) replicate exclusively in targeted tumor cells and release new virus ...
Payal Agarwal, Elizabeth A. Gammon, Maninder Sandey, Stephanie S. Lindley, Jey W. Koehler, Brad M. Matz, Annette N. Smith, Elena A. Kashentseva, Igor P. Dmitriev, David T. Curiel, Bruce F. Smith   +10 more
doaj   +1 more source

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus [PDF]

, 2010
Background CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level
Young Lawrence S, Elmetwali, Taha, Mcneish, I., Searle Peter F, Young, Lawrence, Searle, PF, Palmer Daniel H, McNeish, I, Young, Lawrence S., Palmer, D.H., McNeish, Iain, Peter F Searle, Lawrence S Young, Elmetwali, T., Searle, P.F., Elmetwali Taha, Iain McNeish, Young, LS, McNeish Iain, Palmer, Daniel H., Palmer, DH, Searle, Peter F., Daniel H Palmer, Young, L.S., Taha Elmetwali, Palmer, Daniel, Searle, Peter, Elmetwali, T   +27 more
core   +1 more source

An Oil-Based Adjuvant Improves Immune Responses Induced by Canine Adenovirus-Vectored Vaccine in Mice

Viruses, 2023
There is a significant need for highly effective vaccines against emerging and common veterinary infectious diseases. Canine adenovirus type 2 (CAV2) vectors allow rapid development of multiple vaccines and have demonstrated their potential in animal ...
Manon Broutin, Fleur Costa, Sandy Peltier, Jennifer Maye, Nicolas Versillé, Bernard Klonjkowski   +5 more
doaj   +1 more source

Transient marked reactive lymphocytosis in a puppy suspected to be secondary to recent vaccination

Journal of Small Animal Practice, EarlyView.
A 3‐month‐old male Bernese Mountain dog was presented with a 10‐day history of vomiting, vocalisation and abdominal discomfort following vaccination. Physical examination revealed subtle peripheral lymphadenopathy. Haematological testing revealed borderline anaemia, thrombocytopenia and moderate lymphocytosis with a high proportion of reactive or ...
J. Ruel, T. Ternisien, B. Conversy, C. Bedard, C. Lemieux, J. Sparago   +5 more
wiley   +1 more source