Generation of cell lines to complement Adenovirus vectors using recombination-mediated cassette exchange [PDF]
, 2010 Background Adenovirus serotype 5 (Ad5) has many favourable characteristics for development as a gene therapy vector. However, the utility of current Ad5 vectors is limited by transient transgene expression, toxicity and immunogenicity.
Farley, Daniel C. +8 more
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The role of PML proteins in adenovirus type 5 infection and the type I interferon response [PDF]
Promyelocytic leukaemia (PML) proteins consist of a collection of related isoforms that are the nucleating components of sub-nuclear structures termed PML nuclear bodies (PML NBs). Numerous functions are attributed to PML and PML NBs, including a role
Wright, Jordan
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Adenovirus-based gene therapy approaches for hemophilia B [PDF]
, 2012 Gene therapy can be used to treat devastating inherited diseases, especially diseases and patients that are not suitable for a conventional cure. The blood clotting disorder hemophilia is one of the most extensively studied monogenetic diseases in gene ...
Zhang, Wenli
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One HealthMulti-host communities are perfect scenarios for the emergence and spread of pathogens, threatening the recovery of endangered, isolated, or inbred populations, such as the brown bear (Ursus arctos) in northwestern Spain.
Gloria Herrero-García +14 more
doaj +1 more source
A Community-Derived Outbreak of Adenovirus Type 3 in Children in Taiwan between 2004 and 2005
, 2009 An outbreak of respiratory adenovirus infection in children was observed in northern Taiwan between November 2004 and February 2005. Using polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) to determine the serotype(s) of 172 ...
CHANG, SUI-YUAN;LEE, CHUN-NAN;HUANG, HSUEH-HUANG;CHANG, LUAN-YIN;CHANG, SHU- FANG;LEE, PING-ING;HUANG, LI-MIN;KAO, CHUAN-LIANG +1 more
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Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus [PDF]
, 1994 Endotoxin (lipopolysaccharide, LPS) is commonly found as a contaminant in plasmid DNA preparations. We demonstrate here that the quantities of LPS typically contaminating DNA preparations can generate a toxicity to primary cells (primary human skin ...
Cotten, M. +7 more
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Novel sequence variants of viral hexon and fibre genes in two dogs with canine adenovirus type 1-associated disease [PDF]
, 2017 There is little information on sequence variation of canine adenovirus type 1 (CAdV-1), the aetiological agent of infectious canine hepatitis (ICH). This study reports hexon and fibre gene sequence variants of CAdV-1 in a dog with systemic ICH and a dog ...
Battilani, M +27 more
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Genetic characterization of equine adenovirus type 1
, 2012 Two known serotypes of equine adenovirus (EAdV), equine adenovirus type 1 (EAdV-1) and equine adenovirus type 2 (EAdV-2) have been isolated from horses. EAdV-1 is predominantly associated with upper respiratory tract infections while EAdV-2 appears to be
Vanniasinkam, Thiru +5 more
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Studies of the adenovirus 5 L1 gene aimed at developing L1 gene deficiencies for use in gene therapy vectors [PDF]
Gene therapy is a novel approach to the treatment of human disease that is in its very early stages of development. Its purpose is to add to and/or alter the pattern of gene expression in cells so as to achieve a therapeutic benefit and is being ...
Arslanoglu, Alper
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