Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
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Cell and Gene Therapy in Equine Ocular Disease
Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.ABSTRACT Equine ocular disease is common and often challenging to treat using traditional methods. This has led to the development of new therapies. Like human medicine, veterinary medicine is adopting cellular and gene therapy as innovative approaches. Equine ocular disease is a particularly promising area for these techniques.
Kimberly A. S. Young +2 more
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CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems
Frontiers in Molecular Neuroscience, 2019 The options available for genetic modification of cells of the central nervous system (CNS) have greatly increased in the last decade. The current panoply of viral and nonviral vectors provides multifunctional platforms to deliver expression cassettes to
Danila del Rio +7 more
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Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus [PDF]
, 1994 Endotoxin (lipopolysaccharide, LPS) is commonly found as a contaminant in plasmid DNA preparations. We demonstrate here that the quantities of LPS typically contaminating DNA preparations can generate a toxicity to primary cells (primary human skin ...
Cotten, M. +7 more
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Molecular Therapy: Nucleic Acids, 2019 Gene therapy represents an attractive alternative to treat hemophilia B. Here we established three hepatocyte-derived cell lines based on Huh7, PLC/PRF/5, and Hep3B cells stably carrying a mutated canine FIX (cFIXmut) transgene containing a single point ...
Jian Gao +5 more
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The role of PML proteins in adenovirus type 5 infection and the type I interferon response [PDF]
Promyelocytic leukaemia (PML) proteins consist of a collection of related isoforms that are the nucleating components of sub-nuclear structures termed PML nuclear bodies (PML NBs). Numerous functions are attributed to PML and PML NBs, including a role
Wright, Jordan
core
Restriction Endonuclease Cleavage Maps of the SmaI-D Fragment of Canine Adenovirus Type 1 DNA [PDF]
, 1983 The SmaI-E fragment (15 to 25 map unit position) of canine adenovirus type 1 DNA was cleaved into several specific fragments by restriction endonucleases, BglII, HapII, HinfI, HaeIII, Sau3A, TaqI, AluI, HhaI and Sau96I.
Takami, Masaaki +3 more
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Adenovirus-based gene therapy approaches for hemophilia B [PDF]
, 2012 Gene therapy can be used to treat devastating inherited diseases, especially diseases and patients that are not suitable for a conventional cure. The blood clotting disorder hemophilia is one of the most extensively studied monogenetic diseases in gene ...
Zhang, Wenli
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Isolation and genetic characterization of canine adenovirus type 2 from a domestic dog showing neurological symptoms. [PDF]
Braz J Microbiol, 2021 Chander V +13 more
europepmc +1 more source
Generation of cell lines to complement Adenovirus vectors using recombination-mediated cassette exchange [PDF]
, 2010 Background Adenovirus serotype 5 (Ad5) has many favourable characteristics for development as a gene therapy vector. However, the utility of current Ad5 vectors is limited by transient transgene expression, toxicity and immunogenicity.
Farley, Daniel C. +8 more
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