Results 71 to 80 of about 29,388,619 (175)

Functional organization of the major late transcriptional unit of canine adenovirus type 2

Journal of General Virology, 2009
Vectors derived from canine adenovirus type 2 (CAV-2) are attractive candidates for gene therapy and live recombinant vaccines. CAV-2 vectors described thus far have been generated by modifying the virus genome, most notably early regions 1 and 3 or the fiber gene.
Szelechowski, Marion, Fournier, Annie, Richardson, Jennifer, Eloit, Marc, Klonjkowski, Bernard   +4 more
openaire   +4 more sources

Ca2+‐Activated Cl− Channels: Do Bestrophins and TMEM16A Interact?

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B. Boedtkjer, Vladimir Matchkov   +4 more
wiley   +1 more source

Canine adenovirus serotype 2 isolation and determination of its cultivation parameters

Ветеринария сегодня
Adenovirus infection in dogs caused by canine adenovirus serotype 2 predominantly results in respiratory disease typically manifested by respiratory tract lesions. Infectious laryngotracheitis is the most often recorded in dogs in the central part of the
A. A. Klimova
doaj   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

Ischaemic dermatopathy associated with multiple vaccinations in a miniature poodle

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 10‐year‐old, spayed, female miniature poodle presented with hyperpigmented alopecia. Two months prior, it had received two polyvalent vaccines 2 weeks apart. Erythematous alopecia at the injection sites was initially observed. These rapidly expanded to the ventral neck and thoracic regions after further rabies vaccination.
Daekyung Kim, Sang‐Ik Oh, Jinho Park, Ji‐Seon Yoon   +3 more
wiley   +1 more source

A novel recombinant Peste des petits ruminants-canine adenovirus vaccine elicits long-lasting neutralizing antibody response against PPR in goats. [PDF]

PLoS ONE, 2012
BACKGROUND: Peste des petits ruminants (PPR) is a highly contagious infectious disease of goats, sheep and small wild ruminant species with high morbidity and mortality rates.
Junling Qin, Hainan Huang, Yang Ruan, Xiaoqiang Hou, Songtao Yang, Chengyu Wang, Geng Huang, Tiecheng Wang, Na Feng, Yuwei Gao, Xianzhu Xia   +10 more
doaj   +1 more source

Canine chronic idiopathic rhinitis: management and outcome – a single‐centre retrospective observational study

Journal of Small Animal Practice, Volume 67, Issue 5, Page 460-470, May 2026.
Objectives Canine chronic idiopathic rhinitis is a common cause of nasal disease in dogs but data reporting outcomes following treatment is lacking. The aim was to describe pre‐ and post‐referral management and outcomes of dogs diagnosed with canine chronic idiopathic rhinitis at a single referral centre.
P. M. N. Henry, R. Rizzo, Y. Tan, A. M. Boag, J. Del‐Pozo, G. A. Woods   +5 more
wiley   +1 more source

CAV-2-Mediated GFP and LRRK2G2019S Expression in the Macaca fascicularis Brain

Frontiers in Molecular Neuroscience, 2020
Parkinson’s disease is characterized by motor and nonmotor symptoms that gradually appear as a consequence of the selective loss of dopaminergic neurons in the substantia nigra pars compacta.
Carla di Caudo, Carla di Caudo, Ivan Martínez-Valbuena, Ivan Martínez-Valbuena, Ivan Martínez-Valbuena, Iñaki-Carril Mundiñano, Aurelie Gennetier, Maria Hernandez, Maria Hernandez, Mar Carmona-Abellan, Mar Carmona-Abellan, Irene Marcilla Garcia, Eric J. Kremer, Rosario Luquin, Rosario Luquin, Rosario Luquin   +15 more
doaj   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source